MELLINS, ROBERT B. M.D.1; BALFOUR, HENRY H. JR., M.D.; TURINO, GERARD M. M.D.2; WINTERS, W. M.D.3 Author Information

Abstract Hyperchloremic metabolic acidosis was observed in 11 infants receiving total parenteral nutrition containing mixtures of synthetic L-amino acids. The not due to excessive gastrointestinal or renal losses base as judged by the stool undetermined anion content and urinary net acid excretion, nor it infusion preformed hydrogen ion titratable acidity amino mixtures. Instead, contain an excess cationic acids relation anionic other organic anions. Metabolism these results a ion,...

Renal tubular lesions during the early phases of progressive potassium depletion in rats were found nephrons isolated by microdissection two locations, collecting tubules and proximal convolutions. All other portions nephron, particular "distal tubule," i.e. ascending limbs Henle's loop distal convolutions, showed no structural alterations except passive effects dilatation cellular compression which developed as a result primary disturbances lower system. The affected all uniformly took...

The range of serum inorganic phosphorus was determined (Fiske and SubbaRow method) on a normal population 908 persons. This accomplished by fitting complex curvilinear functions age separately for each sex. These were deemed necessary, because it became apparent that concentration varied with both Ninetynine per cent confidence limits placed the functions, lower limit this belt used as discriminant diagnosis familial hypophosphatemia. Similar fitted sex to 70 affected persons from five...

The effect of graded degrees K depletion on the ability to produce a concentrated urine was studied in Sprague-Dawley rats. With increasing depletion, as measured by concentration fat-free skeletal muscle, there progrossive decrease maximum urinary concentration. This defect renal concentrating mechanism appeared be better correlated with degree than duration potassium and could demonstrated either use exogenous vasopressin or water deprivation. potassium-deficient rats at least one...

Summary A method for the quantitative assessment of balance net acid (NAB) in growing infants with a changing body composition is described. Results seventy measurements daily NAB healthy premature ingesting modified cow's milk formulae are reported. The relative contributions various determinants input infant differ from those normal adult, and growth appears to be associated negative balances due base deposition skeleton new water. load “undetermined anion” (UA) diet was found largest...

Potassium depletion in rats augments the specific renal lesions of phosphate loading. Since it has been shown that loading increases cardiac potassium deficiency (12), is concluded similar types electrolyte imbalance (potassium depletion-phosphate load) act conversely two organs.

The initial disturbances in acid-base equilibrium and the pathways of recovery have been studied 33 patients, predominantly infants young children, with salicylate intoxication due either to accidental ingestion or therapeutic overdosage. In nearly all patients there were significant reductions total content carbon dioxide pCO2 plasma; pH blood did not vary consistently: some alkalotic, others acidotic, while still had no deviation blood. Evidence was obtained many for a mixed disturbance...

Acid-base equilibrium of arterialized capillary blood was determined on 139 normal infants between the ages 3 months and 2 years. The mean standard deviation each component as follows: pH 7.398 ± 0.027, base excess -3.2 1.7 mEq/L, pCO2 33.8 3.7 mm Hg, plasma total CO2 content 21.1 1.9 mM/L. When compared to adult values, all components except were reduced a statistically significant extent. These data are proposed definitive standards for acid-base in this age group.

IN A previous communication from this laboratory (Winters et al., 1952) preliminary evidence was presented suggesting that the pantothenate-deficient rat in fact insufficient with respect to functions usually attributed C-ll oxysteroid of adrenal cortex. This paper is concerned primarily disturbances carbohydrate metabolism which these animals demonstrate. Previous studies on problem are somewhat confusing and thus far have failed clearly define presence or absence significant metabolic...

A case of multiple hemangiomata the liver is reported in an infant who presented signs and symptoms strongly suggesting congenital heart disease. The post mortem examination revealed no gross anomalies or great vessels, but did show a with cardiac hypertrophy. mechanism to explain failure this discussed.