A5076534927- Blood Coagulation and Thrombosis Mechanisms
- Pregnancy and preeclampsia studies
- Maternal and fetal healthcare
- Pregnancy-related medical research
- Maternal and Perinatal Health Interventions
- Venous Thromboembolism Diagnosis and Management
- Cardiovascular Issues in Pregnancy
- Advanced Proteomics Techniques and Applications
- Preterm Birth and Chorioamnionitis
- Congenital Heart Disease Studies
- Trauma and Emergency Care Studies
- Gestational Diabetes Research and Management
- Hemophilia Treatment and Research
- Vaccine Coverage and Hesitancy
- Coronary Artery Anomalies
- COVID-19 Impact on Reproduction
- Bacterial Infections and Vaccines
- Cancer-related Molecular Pathways
- Assisted Reproductive Technology and Twin Pregnancy
- Aortic Disease and Treatment Approaches
- Cardiac Valve Diseases and Treatments
- Acute Myocardial Infarction Research
- Cancer-related gene regulation
- Ubiquitin and proteasome pathways
- Mass Spectrometry Techniques and Applications
University of Vermont
2013-2025
University of Vermont Medical Center
2012-2024
University of Ottawa
2015
National Cancer Institute
2001
Center for Cancer Research
2001
Abstract Objective To identify clinical practice characteristics associated with the frequency of prenatal critical congenital heart disease (CCHD) detection (i.e., number liveborn infants postnatally confirmed CCHD identified on sonography) over 20 years in a rural setting comprised 11 primarily low‐volume obstetric hospitals and single tertiary academic hospital to which they refer. Methods This was retrospective cohort study all patients referral region an initial and/or postnatal...
Abstract Pregnancy and the postpartum period substantially increase risk for thrombotic events. Although absolute thrombosis is low, these events comprise a significant portion of maternal morbidity mortality. The vast majority such are venous, although ischemic stroke also appears to be increased in pregnancy. This review will explore overlapping unique factors venous arterial Diagnosis prevention discussed, treatment briefly touched on. benefit using multidisciplinary model caring pregnant...
The standard clinical coagulation assays, activated partial thromboplastin time (aPTT) and prothrombin (PT) cannot predict thrombotic or bleeding risk. Since thrombin generation is central to haemorrhage control when unregulated, the likely cause of thrombosis, assays (TGA) have gained acceptance as "global assays" haemostasis. These generate an enormous amount data including four key parameters (lag time, maximum rate, peak total thrombin) that may change varying degrees over in...
Characteristics of maternal vascular malperfusion (MVM) are frequently observed in placentas from pregnancies impacted by preeclampsia, intrauterine growth restriction, preterm labor, and fetal demise. We sought to evaluate the associations features MVM with subclinical measures cardiovascular health coagulation potential healthy young women. Sixty-three women were recruited assessed prior pregnancy on cycle day 9 ± 4, at gestational age 90 6 early pregnancy, 216 5 late pregnancy. Women for...
Plasma‐ and platelet‐derived factor Va are essential for thrombin generation catalyzed by the prothrombinase complex; however, several observations demonstrate that cofactor, which is formed following megakaryocyte endocytosis modification of plasma procofactor, V, more hemostatically relevant. Factor V endocytosis, as a function differentiation proplatelet formation, was assessed flow cytometry microscopy in CD34 + hematopoietic progenitor cells isolated from human umbilical cord blood...
Vaginal birth after cesarean can reduce morbidity associated with multiple deliveries. Failed vaginal is increased maternal and neonatal morbidity. The Maternal-Fetal Medicine Units Birth After Cesarean calculator a validated tool to predict the likelihood of successful trial labor cesarean. Predicted < 60% has been We sought determine if formal incorporation calculated into patient-centered counseling would failed cesarean.This quality improvement intervention at single tertiary-care...
pregnancies, AT replacement therapy was prescribed during birth and 8-48 h postpartum.Prior to diagnosis, bilateral iliofemoral DVT observed in 1 patient after delivery.No thrombotic complications were patients treated with LMWH.6 births eutocic 2 instrumental.1 a scheduled cesarean section due IUGR.Mild hemorrhagic appeared 3 resolved curettage, methylergometrine or reduction of LMWH (Table 2). Conclusion(s):Pregnancy ATD increases risk entails high morbi-mortality if thromboprophylaxis is...