A5046195619- Genomics, phytochemicals, and oxidative stress
- Wound Healing and Treatments
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Diabetic Foot Ulcer Assessment and Management
- Histone Deacetylase Inhibitors Research
- MicroRNA in disease regulation
- Adipokines, Inflammation, and Metabolic Diseases
- Vitamin D Research Studies
- Glutathione Transferases and Polymorphisms
- Mesenchymal stem cell research
- Reproductive System and Pregnancy
- Mangiferin and Mango Extracts
- Advanced Biosensing Techniques and Applications
- Molecular Biology Techniques and Applications
- Single-cell and spatial transcriptomics
- Autophagy in Disease and Therapy
- S100 Proteins and Annexins
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Preterm Birth and Chorioamnionitis
- COVID-19 Impact on Reproduction
- Blood groups and transfusion
- Methemoglobinemia and Tumor Lysis Syndrome
- RNA regulation and disease
- Diabetes and associated disorders
SRM Institute of Science and Technology
2019-2025
Inflammation in macrophages is exacerbated under hyperglycemic conditions, contributing to chronic inflammation and impaired wound healing diabetes. This study investigates the potential of mangiferin, a natural polyphenol, alleviate this inflammatory response by targeting redox-sensitive transcription factor, nuclear factor erythroid 2-related 2 (Nrf2). Mangiferin, known Nrf2 activator, was evaluated for its ability counteract hyperglycemia-induced inhibition enhance antioxidant defenses....
Nuclear factor erythroid-2-related 2 (Nrf2) is a stress-activated transcription regulating antioxidant genes, and deficiency thereof, slowing lymphangiogenesis, has been reported in diabetic foot ulcer (DFU). The mode of Nrf2 regulation DFU less explored. Emerging studies on miRNA-mediated target show miRNA to be the leading player pathogenesis disease. In present study, we demonstrated role miR-27b Nrf2-mediated angiogenesis DFU. A lower expression mRNA targets, such as Nrf2, HO-1, SDF-1α,...
Non-healing lesions in diabetic foot ulcers are a significant effect of poor angiogenesis. Epigenetic regulators, mainly lncRNA and miRNA, recognized for their important roles disease progression. We deciphered the regulation NEAT1 through miR-146a-5p/mafG axis progression DFU. A lowered expression was associated with dysregulated angiogenesis reduced mafG, SDF-1α, VEGF chronic ulcer subjects compared to acute This validated by silencing SiRNA endothelial cells which resulted transcriptional...