A5027167908- Immune Cell Function and Interaction
- Respiratory viral infections research
- Autophagy in Disease and Therapy
- Neonatal Respiratory Health Research
- Inflammasome and immune disorders
- Cytokine Signaling Pathways and Interactions
- Mosquito-borne diseases and control
- Tracheal and airway disorders
- interferon and immune responses
- Endoplasmic Reticulum Stress and Disease
- Respiratory Support and Mechanisms
- Congenital Diaphragmatic Hernia Studies
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Pediatric health and respiratory diseases
Emory University
2013-2017
Emory National Primate Research Center
2016
Imperial College London
2011-2013
Dynavax Technologies (United States)
2013
Asthma UK
2012
The Secret Life of a Vaccine Antigen-specific CD8 ÷ T cells play central role in the adaptive immune response to viral infections and cancer. Ravindran et al. (p. 313 , published online 5 December) studied successful yellow fever virus vaccine YF-17D gain insight into its mechanism action. activated nutrient deprivation sensor, GCN2 kinase, dendritic cells. In transgenic mouse models, activation promoted autophagy antigen cross-presentation, enhancing virus-specific cell response. findings...
The inflammatory response to lung infections must be tightly regulated, enabling pathogen elimination while maintaining crucial gas exchange. Using recently described "depletion of regulatory T cell" (DEREG) mice, we found that selective depletion cells (Tregs) during acute respiratory syncytial virus (RSV) infection enhanced viral clearance but increased weight loss, local cytokine and chemokine release, T-cell activation cellular influx into the lungs. Conversely, inflammation was...
Interleukin (IL-) 10 is a pleiotropic cytokine with broad immunosuppressive functions, particularly at mucosal sites such as the intestine and lung. Here we demonstrate that infection of BALB/c mice respiratory syncytial virus (RSV) induced IL-10 production by CD4+ CD8+ T cells in airways later time points (e.g. day 8); proportion these also co-produced IFN-γ. Furthermore, RSV IL-10−/− resulted more severe disease enhanced weight loss, delayed recovery greater cell infiltration tract without...
Antigen-presenting cells (APCs) occupy diverse anatomical tissues, but their tissue-restricted homeostasis remains poorly understood. Here, working with mouse models of inflammation, we found that mechanistic target rapamycin (mTOR)-dependent metabolic adaptation was required at discrete locations. mTOR dispensable for dendritic cell (DC) in secondary lymphoid tissues necessary to regulate cellular metabolism and accumulation CD103+ DCs alveolar macrophages lung. Moreover, while numbers...
ABSTRACT During viral infection, inflammation and recovery are tightly controlled by competing proinflammatory regulatory immune pathways. Respiratory syncytial virus (RSV) is the leading global cause of infantile bronchiolitis, which associated with recurrent wheeze asthma diagnosis in later life. Th2-driven disease has been well described under some conditions for RSV-infected mice. In present studies, we used Foxp3 DTR mice (which allow specific conditional depletion + T cells) to...
Human trials of formaldehyde-inactivated respiratory syncytial virus (FI-RSV) vaccine in 1966–1967 caused disastrous worsening disease and death infants during subsequent natural (RSV) infection. The reasons behind vaccine-induced augmentation are only partially understood, fear continues to hold back development. We now show that mice vaccinated with FI-RSV enhanced local recruitment conventional CD4 + T cells accompanied by a profound loss regulatory (Tregs) the airways. This Tregs was so...
Abstract Intricate overlap between environmental and pathogen derived signals regulate innate immunity, the mechanistic target of rapamycin (mTOR) kinase is a key signal integrator. Recent reports show mTOR inhibition increases proinflammatory activity DCs in vitro, suggesting that DC-targeted inhibitors could adjuvant immunity. We deleted using CD11c Cre/LoxP system (mTOR DCKO), challenged mice with distinct immunological stimuli. In contrast to our expectations, we found no inflammatory...
Abstract Regulatory T cells (Tregs) play a clear role in chronic infections and inflammatory disorders, but their acute have not been fully elucidated. Respiratory syncytial virus (RSV) is the major cause of serious lower respiratory tract infection infants, resulting over-exuberant immune responses. In order to examine Tregs primary RSV infection, we infected “Depletion regulatory cells” (DEREG) mice which express diphteria toxin (DT) receptor enhanced GFP fusion protein under control FOXP3...