A5008775517- Nutrition and Health in Aging
- Endometrial and Cervical Cancer Treatments
- Cancer Diagnosis and Treatment
- Cancer survivorship and care
- Management of metastatic bone disease
- Head and Neck Cancer Studies
- Sarcoma Diagnosis and Treatment
- Body Composition Measurement Techniques
- Cancer Risks and Factors
- Advanced Radiotherapy Techniques
- Ovarian cancer diagnosis and treatment
- Breast Cancer Treatment Studies
- Uterine Myomas and Treatments
- Inflammatory Biomarkers in Disease Prognosis
- Esophageal Cancer Research and Treatment
- Gastric Cancer Management and Outcomes
- Cervical Cancer and HPV Research
- Pelvic and Acetabular Injuries
- Colorectal and Anal Carcinomas
- Esophageal and GI Pathology
- Ultrasound and Hyperthermia Applications
- Dietetics, Nutrition, and Education
- Lung Cancer Diagnosis and Treatment
- Frailty in Older Adults
- Infrared Thermography in Medicine
Mackay Memorial Hospital
2016-2025
Mackay Medical College
2017-2024
Hospital Pulau Pinang
2023
Ministry of Health
2023
National Yang Ming Chiao Tung University
2017-2019
National Yang Ming University Hospital
2017-2019
Nagoya University
1990
Fujita Health University
1990
Purpose: This study investigates the association between body composition change during concurrent chemoradiotherapy (CCRT) and outcome in patients with locally advanced cervical cancer (LACC).Experimental Design: Pre- posttreatment CT images of 245 LACC who were treated 2004 2015 analyzed. Skeletal muscle index (SMI) density (SMD), subcutaneous adipose tissue (SATI), visceral (VATI) measured from two sets at level L3 vertebra. Sarcopenia a low SMD defined using published cut-off points....
Abstract Background Sarcopenia is commonly observed in patients with advanced‐stage epithelial ovarian cancer (EOC). However, the effect of body composition changes—during primary debulking surgery (PDS) and adjuvant platinum‐based chemotherapy—on outcomes EOC unknown. This study aimed to evaluate association between changes stage III treated PDS chemotherapy. Methods Pre‐treatment post‐treatment computed tomography (CT) images 139 were analysed. All CT contrast‐enhanced scans acquired...
Abstract Background Treatment‐related toxicities and decreased levels of patient performance during cancer therapy might contribute to body composition changes thereby impact outcomes. However, the effect longitudinal on outcomes in patients with advanced endometrial is unknown. This study investigated association between staging surgery adjuvant chemoradiotherapy stage III cancer. Methods Pretreatment post‐treatment computed tomography (CT) images 131 who were treated 2008 2016 analysed....
Skeletal muscle loss during treatment is associated with poor survival outcomes in patients ovarian cancer. Although changes mass can be assessed on computed tomography (CT) scans, this labour-intensive process impair its utility clinical practice. This study aimed to develop a machine learning (ML) model predict based data and interpret the ML by applying SHapley Additive exPlanations (SHAP) method.
Sarcopenia and systemic inflammation can affect survival of advanced-stage oral squamous cell carcinoma (OSCC) patients; however, their reciprocal associations with outcomes are yet to be investigated.Retrospective review at a tertiary cancer center.Patients stage III-IVB OSCC that underwent surgery (chemo)radiotherapy our institution between 2010 2015 were reviewed. Skeletal muscle index (SMI) was assessed using computed tomography scans the C3 vertebra. defined lowest sex-specific tertile...
Older adults are among the most vulnerable groups during COVID-19 epidemic, contributing to a large proportion of COVID-19-related death. Medication review and reconciliation by pharmacist can help reduce number potentially inappropriate medications but these services were halted COVID-19.To assess prevalence factors associated with medicine use older populations COVID-19.This was cross-sectional, retrospective analysis hospitalized COVID-19. Potentially medication categorized using Beer's...
Emerging evidence has suggested the safety and efficacy of individualized-uterine radiotherapy in locally advanced cervical cancer. This study aimed to compare clinical outcomes gastrointestinal toxicity whole-uterine women with A retrospective analysis was conducted on 220 patients stage IB3 IVA cancer, treated definitive chemoradiotherapy between 2014 2021 at 2 tertiary centers. The target volume included entire uterus (whole-uterine group) or an based gross tumor a 15 mm margin...
The effect of skeletal muscle loss associated with surgery and adjuvant radiotherapy on survival outcomes in patients early-stage cervical cancer remains unclear. We analyzed the data 133 who underwent between 2013 2018 at two tertiary centers. Skeletal changes were measured using computed tomography scans baseline, simulation for radiotherapy, 3 months post-treatment. A decrease ≥5% was defined as "muscle loss." Patient-Reported Outcome version Common Terminology Criteria Adverse Events...
Malignant ascites is prevalent in advanced-stage ovarian cancer and may facilitate identification of the drivers muscle loss. This study aimed to evaluate association with changes systemic inflammation after treatment cancer.We evaluated 307 patients (III/IVA) who underwent primary debulking surgery adjuvant platinum-based chemotherapy between 2010 2019. The skeletal index (SMI) radiodensity (SMD) were measured using pre-surgery post-chemotherapy portal-venous phase contrast-enhanced...
Patients with locally advanced cervical cancer (LACC) are at risk of para-aortic lymph node (PALN) metastasis. Pelvic concurrent chemoradiotherapy, the current standard treatment for LACC, has a PALN failure rate 9% according to Radiation Therapy Oncology Group Trial 90–01, suggesting that it may not completely eliminate all microscopic tumors in PALNs. To minimize toxicities associated conventional prophylactic extended-field radiotherapy, our institute use semiextended field radiotherapy...
The changes in body composition are early adverse effects of androgen deprivation therapy (ADT); however, their prognostic impact remains unclear prostate cancer. This study aimed to evaluate the association between and survival patients with high-risk We measured skeletal muscle index (SMI) total adipose tissue (TATI) at L3 vertebral level using computed tomography baseline within one year after initiating ADT 125 cancer treated radiotherapy 2008 2018. Non-cancer mortality predictors were...
Objective: Haematological toxicity (HT) is common in patients with oesophageal cancer (EC) treated chemoradiotherapy (CRT). The Quantitative Analysis of Normal Tissue Effects the Clinic guidelines provide no dose constraints for bone marrow (BM) to avoid HT. We aimed determine dosimetric factors associated HT during CRT EC. Methods: 41 EC neoadjuvant cisplatin and 5-fluorouracil-based were retrospectively reviewed. Associations between dose–volume histogram parameters thoracic bones blood...
Objective To evaluate the effects of body mass index (BMI) and weight change during radiotherapy on development toxicity in patients with locally advanced cervical cancer (LACC) treated intensity-modulated (IMRT). Methods A total 245 were analyzed after undergoing definitive IMRT treatment between 2004 2015 for stage IB2 to IVA LACC. The divided into 3 groups: underweight (BMI <18.5 kg/m 2 ), normal 18.5–24.9 overweight ≥25.0 ). relationships toxicity, clinical factors, bowel dose-volume...
This study aimed to evaluate whether computed tomography (CT)-based muscle measurement predicts distant failure in patients with locally advanced cervical cancer (LACC). Data from 278 LACC who underwent chemoradiation therapy (CCRT) between 2004 and 2017 were analysed. Changes the skeletal index (SMI), density, total adipose tissue during CCRT calculated CT images taken at baseline after CCRT. The predictive capability of CT-based for was evaluated using Cox proportional hazards regression,...
The prognostic significance of radiation dose to the lung or heart is unknown in esophageal cancer patients receiving neoadjuvant chemoradiotherapy followed by surgery (trimodal therapy). This study aimed determine association between and volumes prognosis after trimodal therapy. reviewed 123 treated with therapy two tertiary institutions 2010 2015. dose-volume histogram parameter Vx was defined as percentage total organ volume a x (Gy) more. Predictors overall survival (OS) were identified...
Pelvic radiotherapy is associated with gastrointestinal toxicities and deterioration of nutritional status. This study aimed to investigate the association patient-reported outcomes (PROs) status body composition changes in women who underwent hysterectomy post-operative for gynecologic cancer. We analyzed data 210 patients treated pelvic cancer between 2013 2018. The PRO version Common Terminology Criteria Adverse Events (PRO-CTCAE) was used toxicity assessment. Patient-Generated Subjective...