A5000659546- Silymarin and Mushroom Poisoning
- Herbal Medicine Research Studies
- Pharmacological Effects of Natural Compounds
- Selenium in Biological Systems
- Heavy Metals in Plants
- Gut microbiota and health
- Medical and Biological Ozone Research
- Clostridium difficile and Clostridium perfringens research
- Coconut Research and Applications
- Sirtuins and Resveratrol in Medicine
- Berberine and alkaloids research
- Tea Polyphenols and Effects
Czech University of Life Sciences Prague
2020-2024
Trans-resveratrol, a well-known plant phenolic compound, has been intensively investigated due to its association with the so-called French paradox. However, despite high pharmacological potential, trans-resveratrol shown relatively low bioavailability. Trans-resveratrol is metabolized in intestine and liver, yielding metabolites that may be responsible for bioactivity. The aim of this study was investigate compare metabolism (tRes), cis-resveratrol (cRes) dihydroresveratrol (dhRes) an vitro...
This study investigates how the dietary supplement silymarin, interacts with gut microbiota, a focus on aging populations. Using advanced techniques such as next-generation sequencing, NMR, and LC-MS, we analyzed dual impact of microbiome silymarin metabolism effect microbiome's structure function. The research revealed that significantly alters decreasing short-chain fatty acid production (acetate, butyrate, propionate) glucose utilization. Importantly, unveiled age-related differences in...
This study investigates how the dietary supplement silymarin interacts with gut microbiota, a focus on aging populations. Using advanced techniques such as next-generation sequencing, NMR and LC-MS, we analysed dual impact of microbiome metabolism effect microbiome’s structure function. The research revealed that significantly alters decreasing short-chain fatty acid production (acetate, butyrate, propionate) glucose utilization. Importantly, unveiled age-related differences in catabolism....
f silymarin components, particularly isosilybin B, which was associated with higher abundance of Faecalibacterium and Erysipelotrichaceae UCG-003. Conclusion This study provides insights into microbiome functionality in metabolizing dietary flavonolignans, highlighting implications for age-specific nutritional strategies advancing our understanding (poly)phenol metabolism.
f silymarin components, particularly isosilybin B, which was associated with higher abundance of Faecalibacterium and Erysipelotrichaceae UCG-003. Conclusion This study provides insights into microbiome functionality in metabolizing dietary flavonolignans, highlighting implications for age-specific nutritional strategies advancing our understanding (poly)phenol metabolism.
Scope This multi‐omic study investigates the bidirectional interactions between gut microbiota and silymarin metabolism, highlighting differential effects across various age groups. Silymarin, extract from Silybum marianum (milk thistle), is commonly used for its hepatoprotective effects. Methods results An in vitro fermentation colon model was with 20 stool samples obtained healthy donors divided into two A combination of three analytical advanced techniques, namely proton nuclear magnetic...
Scope This multi-omic study investigates the bidirectional interactions between gut microbiota and silymarin metabolism, highlighting differential effects across various age groups. Silymarin, extract from Silybum marianum (milk thistle), is commonly used for its hepatoprotective effects. Methods results An in vitro fermentation colon model was with 20 stool samples obtained healthy donors divided into two A combination of three analytical advanced techniques namely next-generation...