A5038841147- Genetics, Aging, and Longevity in Model Organisms
- Circadian rhythm and melatonin
- Spaceflight effects on biology
- Gene Regulatory Network Analysis
- Aging and Gerontology Research
- Bioinformatics and Genomic Networks
- Dietary Effects on Health
Universitat Pompeu Fabra
2021-2024
Centre for Genomic Regulation
2021-2024
Institute of Science and Technology
2024
Aging involves a transition from youthful vigor to geriatric infirmity and death. Individuals who remain vigorous longer tend live longer, within isogenic populations of C . elegan s the timing age-associated movement cessation (VMC) is highly correlated with lifespan. Yet, many mutations interventions in aging alter proportion lifespan spent moving vigorously, appearing “uncouple” To clarify relationship between cessation, death, physical declines that determine their timing, we developed...
Hydrogen peroxide is the most common reactive chemical that organisms face on microbial battlefield. The rate with which hydrogen damages biomolecules required for life increases temperature, yet little known about how cope this temperature-dependent threat. Here, we show
Genetically identical animals kept in a constant environment display wide distribution of lifespans, reflecting large non-genetic, stochastic aspect to aging conserved across all organisms studied. This component means that order understand and identify successful interventions extend the lifespan or improve health, researchers must monitor populations experimental simultaneously. Traditional manual death scoring limits throughput scale required for large-scale hypothesis testing, leading...
Abstract Individuals who remain vigorous longer tend to live longer, supporting the design of predictive behavioral biomarkers aging. In C. elegans , timing age-associated movement cessation (VMC) and lifespan correlate strongly between individuals. However, many genetic pharmaceutical interventions that alter aging produce disproportional effects on VMC lifespan, appearing “uncouple” rate lifespan. To study causal structure underlying such uncoupling, we developed a high-throughput,...
Abstract Hydrogen peroxide is the most common reactive chemical that organisms face on microbial battlefield. The rate with which hydrogen damages biomolecules required for life increases temperature, yet little known about how cope this temperature-dependent threat. Here, we show Caenorhabditis elegans nematodes use temperature information perceived by sensory neurons to threat of produced pathogenic bacterium Enterococcus faecium . These preemptively induce expression specific defenses in...