A5074522184- Advanced Radiotherapy Techniques
- Endometrial and Cervical Cancer Treatments
- Cervical Cancer and HPV Research
- Advances in Oncology and Radiotherapy
- Diversity and Career in Medicine
- Management of metastatic bone disease
- Colorectal Cancer Surgical Treatments
- Head and Neck Cancer Studies
- T-cell and Retrovirus Studies
- Glioma Diagnosis and Treatment
- Colorectal and Anal Carcinomas
- Molecular Biology Techniques and Applications
- Gastric Cancer Management and Outcomes
- MRI in cancer diagnosis
- Radiomics and Machine Learning in Medical Imaging
- Brain Metastases and Treatment
- Cutaneous Melanoma Detection and Management
- Head and Neck Surgical Oncology
- Mentoring and Academic Development
- Global Health Workforce Issues
- Lung Cancer Research Studies
- Immunotherapy and Immune Responses
- PARP inhibition in cancer therapy
- Pancreatic and Hepatic Oncology Research
- Radiology practices and education
Memorial Sloan Kettering Cancer Center
2022-2025
University of Washington
2019-2022
University of Washington Medical Center
2020
Loma Linda University
2010-2016
Howard University
2011
Université Sorbonne Paris Nord
2007
Inserm
2007
HPV-DNA integration into cellular chromatin is usually a necessary event in the pathogenesis of HPV-related cancer; however, mechanism has not been clearly defined. Breaks must be created both host DNA and circular viral episome for to occur, studies have shown that indeed increased by induction double strand breaks. Inflammation generates reactive oxygen species, which turn potential create such It plausible these breaks enable greater frequency integration, this way contribute...
ABSTRACT High-risk types of human papillomavirus (HPV) are the causative agents virtually all cases cervical cancer and a significant proportion other anogenital cancers, as well both oral pharyngeal cancers. The high-risk encode two viral oncogenes, E6 E7, which work together to initiate cell transformation. Multiple steps involving activities interactions cellular proteins involved in progression from HPV infection transformation cancer. oncoprotein is expressed several isoforms:...
Since the 2009 FIGO staging update, focused exclusively on anatomic extent of disease, there have been several advances in understanding pathologic and molecular features endometrial cancer. In a significant departure from system, 2023 update integrates both histopathological classification. With inclusion non-anatomic parameters such as histology, tumor grade, lymphovascular space invasion, subtype, aims to create more clinically relevant substages that improve prognostic value allows for...
Treatment of advanced and relapsed cervical cancer is frequently ineffective, due in large part to chemoresistance. To examine the pathways responsible, we employed carcinoma-derived SiHa CaSki cells as cellular models resistance sensitivity, respectively, treatment with chemotherapeutic agents, doxorubicin, cisplatin. We compared proteomic profiles identified potential contribute differential response. then extended these findings by comparing expression level genes involved reactive oxygen...
The purpose of this study was to highlight the importance timely brachytherapy treatment for patients with gynecologic, breast, and prostate malignancies, provide a framework clinical practice management in response COVID-19 pandemic.We review amassing evidence help guide timing cancers. Where concrete data could not be found, peer-reviewed expert opinion is provided.There may significant negative impact on oncologic outcomes gynecologic malignancies who have delay completion therapy. Delay...
The recent global events related to the coronavirus disease of 2019 pandemic have significantly changed medical landscape and led a shift in oncologic treatment perspectives. There is renewed focus on preserving outcomes while maintaining accessibility decreasing resource utilization. Brachytherapy, which vital part course many cancers (particularly prostate gynecologic cancers), has ability deliver hypofractionated radiation thus shorten time. Studies early 2000s demonstrated decline...
Advances in radiotherapy have improved tumor control and reduced toxicity the management of nasopharyngeal carcinoma (NPC). Local failure remains a problem for some patients with advanced primary tumors, toxicities are significant given large treatment volume proximity to critical structures, even modern photon-based radiotherapy. Proton therapy has unique dosimetric advantages, recent technological advances now allow delivery intensity-modulated proton (IMPT), which can potentially improve...
The liver is a common site of cancer metastases. Systemic therapy widely accepted as the standard treatment for metastases (LM), although select patients with oligometastases may be candidates potentially curative resection. Recent data support role nonsurgical local therapies such ablation, external beam radiotherapy, embolization, and hepatic artery infusion management LM. Additionally, advanced, symptomatic LM, provide palliative benefit. American Radium Society gastrointestinal expert...
PurposeTo assess physics quality assurance (PQA) practices in less resourced RT-centers to improve of care.MethodsA preliminary study was conducted 2020 thirteen select RT centers six countries and 2021, our team onsite visits all the Ghana, one from initial survey. The included private, two public institutions (denoted Public-1- –2). Follow-up surveys were sent 17 medical physicists site visit. Questions centered on topic equipment, institutional practice, assurance, management, safety...
Background: Abdominoperineal resection (APR) has been advocated for persistent or recurrent disease after failure of chemoradiation (CRT) anal squamous cell cancer (SCC). Treatment with salvage APR can potentially achieve a cure. This study aimed to analyze oncological outcomes in recent time period at comprehensive center. Methods: A retrospective review all patients who underwent biopsy-proven SCC between 1 January 2007 and 31 December 2020 was performed. Patients stage IV the initial...
Proton radiation therapy (PR) is well established in the treatment of pediatric malignancies central nervous system (CNS) with dosimetric advantages that reduce late (RT) effects. In this analysis, we sought to evaluate utilization PR children primary CNS and characterize clinical sociodemographic factors predictive receipt PR.The National Cancer Database was queried identify all patients treated curative intent RT from 2004 2017. Clinical characteristics demographics were analyzed using...
Abstract Background Palmar-plantar erythrodysesthesia (PPE) is a slowly developing cutaneous reaction commonly experienced by patients treated with fluoropyrimidines. While normally presents in palmar-plantar distribution, it can also present genital involvement, but this presentation likely underreported and incorrectly attributed to an acute from radiation therapy. This article aims define of the penis scrotum as rare significant side effect capecitabine. Case We identified five cases...