A5082087379- Immunotherapy and Immune Responses
- Toxin Mechanisms and Immunotoxins
- Influenza Virus Research Studies
- vaccines and immunoinformatics approaches
- T-cell and Retrovirus Studies
- Essential Oils and Antimicrobial Activity
- Immune Cell Function and Interaction
- Natural product bioactivities and synthesis
- Animal Disease Management and Epidemiology
Universidad de la República de Uruguay
2017-2023
Commercially available saponins are extracted from Quillaja saponaria barks, being Quil A
Saponin-based adjuvants are promising that enhance both humoral and T-cell-mediated immunity. One of the most used natural products as vaccine Quillaja saponaria bark saponins its fraction named Quil A®. Despite that, use has been restricted for human due to safety issues. As an alternative, our group studying congener species brasiliensis performance adjuvants, which have shown trigger cellular immune responses comparable A® but with milder side effects. Here, we studied a semi purified...
Vaccination is the most effective public health intervention to prevent influenza infections, which are responsible for an important burden of respiratory illnesses and deaths each year. Currently, licensed vaccines mostly split inactivated, although in order achieve higher efficacy rates, some contain adjuvants. Although split-inactivated induce humoral responses, tailoring mucosal cellular immune responses crucial preventing infections. Quillaja brasiliensis saponin-based adjuvants,...
The threat of viral influenza infections has sparked research efforts to develop vaccines that can induce broadly protective immunity with safe adjuvants trigger robust immune responses. Here, we demonstrate subcutaneous or intranasal delivery a seasonal trivalent vaccine (TIV) adjuvanted the Quillaja brasiliensis saponin-based nanoparticle (IMXQB) increases potency TIV. (TIV-IMXQB) elicited high levels IgG2a and IgG1 antibodies virus-neutralizing capacity improved serum hemagglutination...