A5061533321- Veterinary Oncology Research
- Cancer-related Molecular Pathways
- Muscle Physiology and Disorders
- Inflammatory Myopathies and Dermatomyositis
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Infectious Diseases and Mycology
- Cardiomyopathy and Myosin Studies
- Virus-based gene therapy research
- Eosinophilic Disorders and Syndromes
- Angiogenesis and VEGF in Cancer
- Cancer-related gene regulation
- Ubiquitin and proteasome pathways
- Autophagy in Disease and Therapy
- Muscle and Compartmental Disorders
- Cell Adhesion Molecules Research
- Epigenetics and DNA Methylation
- Genetic Neurodegenerative Diseases
- Skin and Cellular Biology Research
- Veterinary Orthopedics and Neurology
- Helminth infection and control
- Mitochondrial Function and Pathology
- Abdominal Surgery and Complications
- Intestinal and Peritoneal Adhesions
- Wnt/β-catenin signaling in development and cancer
University of Naples Federico II
2015-2024
Federico II University Hospital
2003-2018
Regione Campania
2003
To characterize the presence and behavior of dystrophinopathic myocardial damage in female carriers a gene defect at Xp21 locus X chromosome that causes Duchenne Becker muscular dystrophies (DMD BMD).Cohort study from April 1, 1985, to 30, 1995, with cardiologic follow-up performed yearly for minimum 3 maximum 10 years.Counseling center genetic disorders.A total 197 women girls aged 5 60 years ascertained be DMD (n = 152) or BMD 45) gene.Cardiac status examinations as determined by 12-lead...
Vascular endothelial growth factor (VEGF) is a dimeric protein that stimulates angiogenesis in vitro and vivo by inducing cell proliferation migration. In this immunohistochemical study, VEGF-immunolabeled cells were counted series of 10 benign 40 malignant canine mammary tumors. The morphologic pattern VEGF positivity (intensity immunolabeling granule size distribution) was also evaluated. A low number weakly positive for with few small granules polarized to the luminal pole detected...
In order to characterize the inflammatory phenotype of livers sheep naturally infected by cystic echinococcosis, 100 have been macroscopically assessed for presence hydatid cysts and sampled histopathological molecular analysis. According gross microscopic examination, were subsequently classified into three groups: normal liver (Group A), with fertile B), sterile C). Immunohistochemical analyses accomplished using primary antibodies anti-Iba1, anti-CD3, anti-CD20, anti-TGF-β, anti-MMP9....
Inflammatory myopathy (IM) and myocarditis are relevant complications of human immunodeficiency virus (HIV) infection. IM has also been reported in adult cats with experimental feline (FIV) The present study investigated naturally FIV-infected for further characterized the inflammatory processes their potential pathogenesis. Snap-frozen skeletal muscle (quadriceps femoris (QF) triceps brachii (TB) muscles) myocardial samples from controls were examined histologically by immunohistochemistry...
White striping (WS) is an emerging myopathy of broiler chickens characterized by white striation muscle. Despite the recent advances, pathomechanism underlying WS remains elusive. The aim this study was to characterize morphological and molecular features in chickens. 50 pectoralis muscles were collected from 55 days old ROSS 308 with a mean weight 3.5 kg. Samples snap frozen analyzed histopathology, immunohistochemistry, immunofluorescence. Real-time-PCR used evaluate expression different...
<b>Introduction</b> Carbon dioxide (CO<sub>2</sub>) used in laparoscopy evokes local and systemic effects. This study was designed to evaluate the histopathologic morphologic changes due CO<sub>2</sub> air insufflation, at different pressure levels, on visceral parietal peritoneum rats. <b>Materials Methods</b> A total of 56 rats were object study, randomly divided into five groups. Pneumoperitoneum (PN) maintained for 30 minutes, a flow rate 0.5 L/min 10 6 mm Hg with (group S1–S2, <i>n</i>...
Sarcopenia, the age-related loss of muscle mass and strength, is a multifactorial condition that represents major healthcare concern for elderly population. Although its morphologic features have been extensively studied in humans, animal models, domestic wild animals, only few reports about spontaneous sarcopenia exist other long-lived animals. In this work, samples from 60 healthy Podolica-breed old cows (aged 15–23 years) were examined compared with 10 young (3–6 years old). Frozen...
The aim of this study was to correlate nuclear morphometric features with animal and human World Health Organization International Histological Classifications in canine seminomas. Twenty-three seminomas were classified, according Animal Classification as intratubular, intratubular signs invasion, or diffuse Human criteria spermatocytic typical. morphonuclear characteristics tumors quantitatively evaluated by means digital cell image analyses hematoxylin eosin-stained nuclei. In particular,...
Abstract Idiopathic inflammatory myopathies (IIMs) are disorders of unknown origin. On the basis clinical, histopathological, and immunological features, they can be differentiated into three major distinct subsets: dermatomyositis; polymyositis; inclusion‐body myositis. Although a few animal models for IIM currently available, lack several characteristic aspects IIMs. The aim our study was to examine skeletal muscle involvement in an experimental model visceral leishmaniasis, disseminated...
Canine angiostrongylosis is a nematode infection in domestic dogs and wild carnivores. The present report focuses on epidemiological, clinical histopathological findings case of fatal disseminated dog living southern Italy provides data the extent spread Angiostrongylus vasorum same area.A 4-year-old female English Setter from Campania region was referred with 2-week history cough severe respiratory distress that did not respond to antimicrobial therapy. Based clinical, radiological,...
// Vincenza Leone 1 , Concetta Langella Francesco Esposito Claudio Arra 2 Giuseppe Palma Domenica Rea Orlando Paciello 3 Merolla Davide De Biase Serenella Papparella Angela Celetti Alfredo Fusco 1, 4 Istituto per l'Endocrinologia ed Oncologia Sperimentale del CNR e/o Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi Napoli "Federico II", Naples, Italy Nazionale lo Studio la Cura dei Tumori "Fondazione Giovanni Pascale", IRCCS, Department of Pathology and...
The transgenic LmnaG609G progeric mouse represents an outstanding animal model for studying the human Hutchinson-Gilford Progeria Syndrome (HGPS) caused by a mutation in LMNA gene, coding nuclear envelope protein Lamin A/C, and, as important, more general scope, complex process governing physiological aging humans. Here we give comprehensive description of peculiarities related to breeding mice over prolonged period time, and many features observed large colony 2-years period. We describe...
Abstract NLRP3 inflammasome is a multiprotein complex that can sense several stimuli such as autophagy dysregulation and increased reactive oxygen species production stimulating inflammation by priming the maturation of proinflammatory cytokines interleukin‐1β interleukin‐18 in their active form. In aging brain, these mediate innate immunity response microglial activation. Here, we describe results immunohistochemical molecular analysis carried out on bovine brains. Our support hypothesis...
The aim of this study was to investigate the correlation between infection by Dicrocoelium dendriticum (class Trematoda) and animal host response in terms macroscopic lesions, immunopathological response, histological changes livers naturally infected sheep. Twenty-four sheep were selected on basis positive D. fecal egg counts (FECs). Gross injuries scored. A significant association observed number adult worms recovered from liver, FEC, fibrosis, bile duct hyperplasia. negative among these...
Background: Ehlers‐Danlos syndrome comprises a group of rare inherited connective tissue diseases characterized by skin hyperextensibility, joint laxity, and vessel fragility, poor wound healing. Objective: The purpose this report was to describe the clinical, histologic, ultrastructural findings in 2 dogs with collagenopathies consistent syndrome. Methods: Two were examined clinically; extensibility index calculated. Skin biopsies obtained from dorsum light electron microscopy. Results:...