A5088210421- Transcranial Magnetic Stimulation Studies
- Neurological disorders and treatments
- Advanced Neuroimaging Techniques and Applications
- Stroke Rehabilitation and Recovery
- Botulinum Toxin and Related Neurological Disorders
- Muscle activation and electromyography studies
- EEG and Brain-Computer Interfaces
- Parkinson's Disease Mechanisms and Treatments
- Functional Brain Connectivity Studies
- Motor Control and Adaptation
- Traumatic Brain Injury Research
- Advanced MRI Techniques and Applications
- Neuroscience and Neural Engineering
- Genetic Neurodegenerative Diseases
- Cerebral Palsy and Movement Disorders
- Neural dynamics and brain function
- Multiple Sclerosis Research Studies
- Vestibular and auditory disorders
- Autism Spectrum Disorder Research
- Pain Management and Treatment
- Psychosomatic Disorders and Their Treatments
- Dementia and Cognitive Impairment Research
- Long-Term Effects of COVID-19
- Neuroscience and Neuropharmacology Research
- Musculoskeletal pain and rehabilitation
Centro Neurolesi Bonino Pulejo
2015-2025
University of Messina
2015-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2015-2024
New York University
2009-2022
Weatherford College
2022
Ben-Gurion University of the Negev
2020
Champalimaud Foundation
2020
Centro Hospitalar de Lisboa Ocidental
2020
NYU Langone Health
2015-2018
University of Turin
2017
Low‐frequency median nerve stimulation, paired with suprathreshold transcranial magnetic stimulation (TMS) over the optimal site for activation of abductor pollicis brevis (APB) muscle induces a long‐lasting increase in excitability corticospinal output neurons, if is given 25 ms before TMS. Here we employed this protocol to assess associative plasticity primary motor hand area 10 patients writer’s cramp and age‐matched controls. Motor evoked potentials (MEPs) were recorded from right APB...
A traumatic brain injury (TBI) is a major health issue affecting many people across the world, causing significant morbidity and mortality. TBIs often have long-lasting effects, disrupting daily life functionality. They cause two types of damage to brain: primary secondary. Secondary particularly critical as it involves complex processes unfolding after initial injury. These can lead cell death in brain. Understanding how these crucial for finding new treatments. This review examines wide...
The excitability of inhibitory circuits in patients with writer's cramp is reduced at multiple levels within the sensorimotor system, including primary motor hand area (M1). Although this may play a major role pathophysiology cramp, it still unclear what factors cause imbalance between inhibition and excitation to arise. One possibility that homeostatic mechanisms keep cortical normal physiological range are impaired. In eight healthy age-matched controls, we combined low-frequency...
<h3>Objective:</h3> To test whether abnormal sensorimotor plasticity in focal hand dystonia is a primary abnormality or merely consequence of the dystonic posture. <h3>Methods:</h3> This study used paired associative stimulation (PAS) paradigm, an experimental intervention, capable producing long term potentiation (LTP) like changes system humans. PAS involves transcranial magnetic combined with median nerve stimulation. 10 patients cranial and cervical dystonia, who showed no symptoms hand,...
Repetitive transcranial magnetic stimulation (rTMS) induces neuronal long-term potentiation or depression. Although brain-derived neurotrophic factor (BDNF) and its cognate tyrosine receptor kinase B (TrkB) contribute to the effects of rTMS, their precise role underlying mechanism remain poorly understood. Here we show that daily 5 Hz rTMS for d improves BDNF–TrkB signaling in rats by increasing affinity BDNF TrkB, which results higher tyrosine-phosphorylated increased recruitment PLC-γ1...
Dystonia is characterized by two main pathophysiological abnormalities: 'reduced' excitability of inhibitory systems at many levels the sensorimotor system, and 'increased' plasticity neural connections in circuits a brainstem spinal level. A surprising finding recent papers has been fact that abnormalities inhibition similar to those organic dystonia are also seen patients who have psychogenic dystonia. To try determine critical feature might separate conditions, we investigated cortical...
Summary: Purpose: To assess the effectiveness of slow repetitive transcranial magnetic stimulation (rTMS) as an adjunctive treatment for drug‐resistant epilepsy. Methods: Forty‐three patients with epilepsy from eight Italian Centers underwent a randomized, double‐blind, sham‐controlled, crossover study on clinical and EEG effects rTMS. The stimulus frequency was 0.3 Hz. One thousand stimuli per day were given at resting motor threshold intensity 5 consecutive days, round coil vertex....
Much of our present understanding the function and operation basal ganglia rests on models anatomical connectivity derived from tract-tracing approaches in rodents primates. However, last years have been characterized by promising step forwards vivo investigation comprehension brain humans. The aim this review is to revise current knowledge circuits, highlighting similarities differences across species, order widen perspective intricate model system. This will allow us explore implications...
The claustrum is a thin layer of gray matter that at the center an active scientific debate. Recently, Constrained Spherical Deconvolution (CSD) tractography has proved to be extraordinary tool allowing track white fibers from cortex cortical and subcortical targets with subvoxel resolution. aim this study was evaluate claustral connectivity in human brain. Ten normal brains were analyzed by using High Angular Resolution Diffusion Imaging CSD-based technique. Tractography revealed 4 groups...