The use of nanoparticles improves the stability, solubility, and skin permeability natural compounds in skincare products. Based on these advantages, this study aimed to incorporate Phlomis crinita extract into polymeric improve its topical delivery for wound healing purposes. involved preparation PLGA PLGA-PEG (PCE-PLGA-NPs PCE-PLGA-PEG-NPs) using solvent displacement method, physicochemical biopharmaceutical characterization, tolerance studies by HET-CAM assay evaluation integrity...

Donepezil (DPZ) is widely used in the treatment of Alzheimer's disease tablet form for oral administration. The pharmacological efficacy this drug can be enhanced by use intranasal administration because route makes bypassing blood⁻brain barrier (BBB) possible. aim study was to develop a nanoemulsion (NE) as well with combination bioadhesion and penetration enhancing properties (PNE) order facilitate transport DPZ from nose-to-brain. Composition NE established using three pseudo-ternary...

Donepezil (DPZ) is widely prescribed as a specific and reversible acetylcholinesterase inhibitor for the symptomatic treatment of mild to moderate Alzheimer's disease (AD).Considering therapeutic potential DPZ advantages offered by intranasal route an alternative drug administration, aim this study was development characterization microemulsion (ME) nose-to-brain delivery.The ME developed construction pseudoternary phase diagrams characterized dynamic light scattering transmission electron...

Pioglitazone has been reported in the literature to have a substantial role improvement of overall cognition mouse model. With this mind, aim study was determine most efficacious route for administration nanoparticles (PGZ-NPs) order promote drug delivery brain treatment Alzheimer's disease. PGZ-loaded NPs were developed by solvent displacement method. Parameters such as mean size, polydispersity index, zeta potential, encapsulation efficacy, rheological behavior, and short-term stability...

Pioglitazone (PGZ) is a drug used to treat type 2 diabetes mellitus that has been reported show additional therapeutic activities on diverse inflammatory parameters. The aim of this study was optimize topical PGZ-loaded nanoemulsion (PGZ-NE) in order evaluate its effectiveness for treating atopic dermatitis (AD). composition the nanoformulation established by pseudo-ternary diagram. Parameters such as physical properties, stability, vitro release profile, and ex vivo permeation were...

Apremilast (APM) is a novel drug for the treatment of psoriasis and psoriatic arthritis. APM phosphodiesterase 4 (PDE4) inhibitor, raising intracellular cAMP levels thereby decreasing inflammatory response by modulating expression TNF-α, IL-17, IL-23, other cytokines. The goal this study to develop gels as new pharmaceutical formulation topical psoriasis. was solubilized in Transcutol-P incorporated into Pluronic F127, Sepigel, carbomer bases at different proportions. All formulations were...

Baricitinib, commonly used for autoimmune diseases, is typically administered orally, which can lead to systemic adverse effects. A topical formulation could potentially offer localized therapeutic effects while minimizing these side

The present study was designed to develop a thermoreversible gel of Pluronic (P407) loaded amphotericin B (AmB-gel) for the dermal and vaginal treatment candidiasis. P407 used as copolymer exploit potential advantages related increasing drug concentration in tissue layer order provide local effect. Parameters including internal structure, swelling, porosity, short-term stability were determined. In addition, release profile ex vivo skin permeation studies carried out. Antifungal efficacy...

Background/Objectives: Leishmaniasis is a neglected tropical disease caused by protozoan parasite of Leishmania. This study aimed to evaluate the in vitro efficacy and toxicity previously developed amphotericin gel as possible treatment for cutaneous leishmaniasis. Methods: First, quality control AmB-gel was carried out, including microbiological stability. The permeated retained drug tested on healthy lacerated human skin. Tolerance using HaCaT, RAW 264.7, J774 cell lines an irritation test...

Apremilast (APR) is a selective phosphodiesterase 4 inhibitor administered orally in the treatment of moderate-to-severe plaque psoriasis and active psoriatic arthritis. The low solubility permeability this drug hinder its dermal administration. purpose study was to design characterize an apremilast-loaded microemulsion (APR-ME) as topical therapy for local skin inflammation. Its composition determined using pseudo-ternary diagrams. Physical, chemical biopharmaceutical characterization were...

Transmucosal delivery is commonly used to prevent or treat local diseases. Pranoprofen an anti-inflammatory drug prescribed in postoperative cataract surgery, intraocular lens implantation, chorioretinopathy, uveitis, age-related macular degeneration cystoid edema. can also be for acute and chronic management of osteoarthritis rheumatoid arthritis. Quality by Design (QbD) provides a systematic approach development maps the influence formulation components. The aim this work was develop...

Alzheimer's disease is characterized by a progressive deterioration of neurons resulting in steady loss cognitive functions and memory. Many treatments encounter the challenge overcoming blood-brain barrier, thus intranasal route non-invasive effective alternative that enhances drug delivery target organ-the brain-and reduces side effects associated with systemic administration. This study aimed at developing gels donepezil as an approach to disease. Three different were elaborated terms pH,...

Essential oils are a complex mixture of aromatic substances whose pharmacological actions, including antimicrobial, antioxidant, anticancer, and anti-inflammatory activities, have been widely reported. This study aimed to evaluate the anti-Candida dermal activity essential from native cultivated Ecuadorian plants. Bursera graveolens, Dacryodes peruviana, Mespilodaphne quixos, Melaleuca armillaris were isolated by hydrodistillation characterized physically chemically. Its tolerance was...

Rosacea is the most common inflammatory skin disease. It characterized by erythema, papules and pustules, visible blood vessels, telangiectasia. The current treatment has limitations unsatisfactory results. Pioglitazone (PGZ) an agonist of peroxisome proliferator-activated receptors (PPARs), a nuclear receptor that regulates important cellular functions, including responses. purpose this study was to evaluate permeation PGZ with selection penetration enhancers analyze its effectiveness for...

The poor water solubility of apremilast (APR) is the main impediment to penetration drug through skin barrier. objective this study was evaluate permeability APR in different solutions enriched with promoters ex vivo samples human skin, and additionally assess its tolerance vivo. To end, 5% promoter were developed, drug’s ability penetrate abdominal evaluated; coefficients permeability, cumulated amounts permeated, flow some parameters likewise, vitro evaluated. results obtained showed that...

Caspofungin is a drug that used for fungal infections are difficult to treat, including invasive aspergillosis and candidemia, as well other forms of candidiasis. The aim this study was incorporate Azone in caspofungin gel (CPF-AZ-gel) compare it with promoter-free (CPF-gel). An vitro release using polytetrafluoroethylene membrane ex vivo permeation into human skin adopted. tolerability properties were confirmed by histological analysis, an evaluation the biomechanical undertaken....

The higher molecular weight and low solubility of amphotericin B (AmB) hinders its topical administration. aim this study was to incorporate Bursera graveolens essential oil into an AmB gel (AmB + BGEO gel) in order promote the diffusion drug through skin treatment cutaneous candidiasis. formulation determined using a factorial experiment. Physical chemical parameters, stability, vitro release profile ex vivo permeation human were evaluated. In antimicrobial activity studied strains C....

A biocompatible topical thermo-reversible hydrogel containing Pranoprofen (PF)-loaded nanostructured lipid carriers (NLCs) was studied as an innovative strategy for the treatment of skin inflammatory diseases. The PF-NLCs-F127 characterized physiochemically and short-time stability tests were carried out over 60 days. In vitro release ex vivo human permeation studies in Franz diffusion cells. addition, a cytotoxicity assay using HaCat cell line tolerance study performed humans by evaluating...

Recently, the number of people acquiring tattoos has increased, with gaining significant popularity in between 20 and 40 years old. Inflammation is a common reaction associated tattooing. The purpose this study was to evaluate nanostructured lipid carrier loading pranoprofen (PRA-NLC) as tattoo aftercare formulation reduce inflammation In context, vitro drug release ex vivo permeation-through-human-skin tests using Franz cells were appraised. tolerance our on skin evaluated by studying...

Essential oils are natural aromatic substances that contain complex mixtures of many volatile compounds frequently used in pharmaceutical and cosmetic industries. Dacryodes peruviana (Loes.) H.J. Lam is a native species from Ecuador whose anti-inflammatory activity has not been previously reported, thus the aim this study was to evaluate D. essential oil. To end, oil fruits isolated by hydrodistillation characterized physically chemically. The tolerance analyzed cytotoxicity studies using...

Leishmaniasis is a neglected tropical disease that requires timely and inexpensive treatment. For this purpose, nanoemulsion with polyene macrolide antibiotic, or amphotericin B (NE-AmB), was developed. This study quantified the amount of drug permeated retained in intact lacerated human skin, simulating cutaneous leishmaniasis (CL) processes. Toxicity macrophage keratinocyte cell lines, activity against promastigotes amastigotes Leishmania tropica, vivo irritant activity, histological...

La aparición de resistencia a los antibióticos por parte S. aureus se ha convertido en un grave problema salud pública. Se determinó el porcentaje meticilino-resistente (SARM) 96 aislamientos clínicos que encontraban banco bacterias laboratorio MEIZ la Escuela Microbiología UNAH. Las pruebas utilizadas para determinar SARM fueron mediante difusión disco utilizando: oxacilina (1µg), meticilina (5µg) y cefoxitina (30 µg). Concentración Mínima Inhibitoria (CMI) obtuvo con prueba E-test® (Solna,...