A5088250101- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Pain Management and Placebo Effect
- Pain Mechanisms and Treatments
- Pediatric Pain Management Techniques
- Intensive Care Unit Cognitive Disorders
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Immune Cell Function and Interaction
- Empathy and Medical Education
- Health, psychology, and well-being
- Psychosomatic Disorders and Their Treatments
- Mindfulness and Compassion Interventions
- Immune responses and vaccinations
- Neuroendocrine regulation and behavior
- Gastrointestinal motility and disorders
- Adenosine and Purinergic Signaling
- Vagus Nerve Stimulation Research
- Bipolar Disorder and Treatment
- Renal Transplantation Outcomes and Treatments
- Mental Health Research Topics
- Diet and metabolism studies
- Schizophrenia research and treatment
- Cultural Differences and Values
- Memory and Neural Mechanisms
- Adrenal Hormones and Disorders
Ruhr University Bochum
2021-2022
University of Duisburg-Essen
2015-2020
Mental Health Research Center of Russian Academy of Medical Sciences
2012-2016
Patients after organ transplantation or with chronic, inflammatory autoimmune diseases require lifelong treatment immunosuppressive drugs, which have toxic adverse effects. Recent insight into the neurobiology of placebo responses shows that associative conditioning procedures can be employed as placebo-induced dose reduction strategies in an immunopharmacological regimen. However, it is unclear whether learned immune produced patient populations already receiving Thus, 30 renal transplant...
Salivary alpha-amylase activity (sAA) and plasma noradrenaline (NA) concentrations are often considered to be surrogate markers of sympathetic activation in response stress. However, despite accumulating evidence for a close association between sAA other indicators activity, reliability generality this relation remains unclear. We employed the Trier Social Stress Test (TSST) order directly compare responses NA psychological stress healthy volunteers (n = 23). The TSST significantly increased...
Abstract The formation and persistence of negative pain-related expectations by classical conditioning remain incompletely understood. We elucidated behavioural neural correlates involved in the acquisition extinction towards different threats across sensory modalities. In two complementary functional magnetic resonance imaging studies healthy humans, differential paradigms combined interoceptive visceral pain with somatic (study 1) aversive tone 2) as exteroceptive threats. Conditioned...
Inflammation could impact on the formation and persistence of interoceptive fear hypervigilance, with relevance to psychiatric disorders chronic pain. To systematically analyze effects inflammation learning extinction, we performed two complementary randomized, double-blind, placebo-controlled functional magnetic resonance imaging (fMRI) studies combining experimental endotoxemia as a translational model acute systemic two-day multiple-threat conditioning paradigm involving exteroceptive...
The relevance of contextual factors in shaping neural mechanisms underlying visceral pain-related fear learning remains elusive. However, benign interoceptive sensations, which shape patients' clinical reality, may context-dependently become conditioned predictors impending pain. In a novel context-dependent conditioning paradigm, we elucidated the putative role central network acquisition and extinction induced by cues pain-predictive contexts. this fMRI study involving rectal distensions...
PurposeThe learned immunosuppressive placebo response has been demonstrated in experimental animals, healthy humans, and patients, is suggested as a therapy for improving immunopharmacologic treatment. It remains unclear, however, whether potential adverse events induced by the drug are also behaviorally conditioned. Employing an established taste–immune learning paradigm humans using calcineurin inhibitor cyclosporine A (CsA) unconditioned stimulus, we investigated to what extent perceived...
Changes in the parameters of innate immunity patients with schizophrenia are observed already first episode. The study was performed to find out whether these changes take place prior disease manifestation, and what role do they play pathogenesis schizophrenia.Thirty-five male nonpsychotic at high risk psychosis, aged between 17 23 years, were examined. Phagocyte activity (PA) neutrophils blood serum evaluated by number active neutrophils, i.e. phagocytic index (PhI), (PhN), which determined...
Background: Calcineurin-inhibitors (CNI) are used in renal transplant patients (RTX) to prevent rejection. CNI mainly suppress T-cell mediated immunity but very little is known about the impact of long-term treatment with on function. Objective: We investigated immunological effects intake RTX comparison short-term administration healthy controls (HC). Methods: Blood was drawn from 30 treatment. In addition, blood sampled HC (four dosages) before first and 2 hours after last CsA intake....
A role of the immune system in pathophysiology pain and hyperalgesia has received growing attention, especially context visceral gut-brain axis. While acute experimental inflammation can induce as part sickness behavior healthy individuals, it remains unclear if normal plasma levels circulating pro-inflammatory cytokines contribute to interindividual variability sensitivity. We herein compiled data from a tightly screened well-characterized sample volunteers ( N = 98) allowing us assess...