A5073026901- Inflammasome and immune disorders
- Heme Oxygenase-1 and Carbon Monoxide
- Autophagy in Disease and Therapy
- Drug-Induced Hepatotoxicity and Protection
- Impact of Technology on Adolescents
- Alcohol Consumption and Health Effects
- Chemotherapy-induced organ toxicity mitigation
- Respiratory Support and Mechanisms
- Pharmacogenetics and Drug Metabolism
- Technostress in Professional Settings
- Cancer Treatment and Pharmacology
- Immune Response and Inflammation
- Peroxisome Proliferator-Activated Receptors
- Chemotherapy-induced cardiotoxicity and mitigation
- Cholesterol and Lipid Metabolism
- Chronic Kidney Disease and Diabetes
- Knowledge Management and Sharing
- Pharmacological Effects of Natural Compounds
- Gout, Hyperuricemia, Uric Acid
- Sodium Intake and Health
Chung Shan Medical University
2022-2025
Pulmonary injury is defined as a progressive inflammation. Extensive pro-inflammatory cytokines are secreted from alveolus, associated with the production of reactive oxygen species (ROS) and apoptosis. The model endotoxin lipopolysaccharide (LPS)-stimulated lung cells has been applied to mimic pulmonary injury. Some antioxidants anti-inflammatory compounds can be used chemopreventive agents Quercetin-3-glucuronide (Q3G) showed exert antioxidant, anti-inflammatory, anti-cancer, anti-aging...
Metabolic syndrome (MetS) poses considerable toxicological risks due to its association with an increased likelihood of metabolic dysfunction-associated steatotic liver disease (MASLD), and is characterized by hypertension, hyperglycemia, dyslipidemia, obesity. This study aimed investigate the therapeutic potential flavonoid-rich lotus seedpod extract (LSE) in alleviating MetS MASLD-related hepatic disturbances. In vivo, mice subjected a high-fat diet (HFD) streptozotocin (STZ) injection...
The aim is to investigate the effect of lotus (Nelumbo nucifera Gaertn.) seedpod extract (LSE) on acetaminophen (APAP)-induced hepatotoxicity. LSE rich in polyphenols and has potent antioxidant capacity. APAP a commonly used analgesic, while overdose main reason for drug toxicity liver. Until now, there been no vitro test drug-induced hepatotoxicity responses. LSEs were evaluate APAP-induced cytotoxicity, ROS level, apoptotic rate, molecule mechanisms. co-treatment elevated survival rate...
Cisplatin has been considered a chemotherapeutic drug for treating human tumors, and one of the noteworthy side effects cisplatin is nephrotoxicity. Amelioration cisplatin-induced nephrotoxicity necessary. Lotus seedpod extract (LSE) mainly composed quercetin-3-glucuronide revealed antioxidant anti-tumor effects. However, LSE on are still unknown. This study aims to explore in vitro vivo protective effect possible mechanism Results showed that co-treatment with raised viability rat renal...