This study aimed to develop valsartan (VAL)-loaded mixed micelles and investigate their cardioprotective potential molecular mechanisms through Mhrt/Nrf2 Trx1 pathways. VAL-loaded have not been elaborated impact on pathways has yet inspected. were prepared, incorporating Pluronic F127 Tween 80, adopting thin-film hydration method. The evaluated for drug entrapment efficiency, loading characteristics, particle size, morphology, in vitro release storage stability. pharmacokinetic studies...

Control of hypertension is a very difficult issue. Non-adherence to medications well-recognized factor contributing uncontrolled hypertension. It required detect factors that affect adherence patients antihypertensive at different societies and good planning with the collaboration governments, universities, media, pharmaceutical companies, civil society create intervention programs ensuring medications. In our study, we aimed determine affecting in Upper Egypt societies.From September 2015...

Background: Pulmonary hypertension (PH) is one of the most common complications developed during course chronic obstructive pulmonary disease (COPD). Platelet activation plays an important role in its pathophysiology, and mean platelet volume (MPV) considered a respectable index activation. The aim this work to assess ability MPV predicting PH secondary COPD as well severity. Methods: A cross-sectional study was conducted on 228 stable patients. CBC, echocardiography, function tests were...

A large percentage of diabetic patients also have other components metabolic syndrome, which is a group cardiovascular (CV) hazard factors related to both diabetes mellitus (DM) and diseases (CVD). We do not know about the prevalence CV risk in Upper Egypt. aimed assess type 2 Egypt villages.We conducted cross-sectional study that included 800 with DM. classified participants into three groups according hemoglobin A1c (HbA1c) levels. assessed their association HbA1c levels through detailed...

Background: Children with nephrotic syndrome (NS) are at a greater risk of atherosclerosis due to recurrent exposures hyperlipidemia, hypertension, and immunosuppressive medications. CIMT (carotid intima media thickness) is reliable marker for assessment large medium-sized blood vessels; endothelial dysfunction increased usually precede the development cardiovascular diseases. Some manifestations NS, like proteinuria associated an cardiac morbidity mortality. The aim current study was...

Abstract Background Conflicting data were found regarding the anemia’s effect on percutaneous coronary intervention (PCI) outcomes. We directed our study to investigate clinical in-stent restenosis (ISR) following PCI. Results A prospective multi-center cohort was performed 470 consecutive participants undergoing elective classified into two groups: group 1 who anemic and 2 non-anemic as a control group. At 1, 3, 6, 12 months by clinic visits, we followed up with patients assess ISR effect....

Abstract Background Trans-ulnar approach was proposed primarily for elective procedures in patients not suitable trans-radial that introduced two decades ago. The trans-ulnar is as safe and effective the coronary angiography intervention. Aim This study’s aim to assess feasibility safety of a preliminary experience operators experienced with no/minimal at an Egyptian center. Results Vascular access 120 selected randomly angioplasty—80 through radial 40 ulnar approach. Patients were examined...

A little is known about the risk factors and predictors of pulmonary embolism (PE) in Coronavirus disease 2019 (Covid-19) infected patients. Therefore, we directed this study to investigate PE patients with Covid - 19 Upper Egypt.We conducted a retrospective cohort on 297 COVID-19, aged ≥ 18 years old. Suspicion COVID-19 infection was based World Health Organization (WHO) criteria confirmed by nasal pharyngeal swab for real-time reverse transcriptase-polymerase chain reaction (RT-PCR)...

Objective: Hypertension leads to left ventricular hypertrophy which directly predisposes and aggravates irreversible deterioration of LV function. Novel quantitative techniques in echocardiographic deformation imaging such as speckle-tracking echocardiography (STE) can measure strain. In this study, we will test a diagnostic tool for the early detection cardiac malfunction due arterial hypertension Design method: This cross-sectional, case-control study was held at Beni Suef University...

Background: Cardiac resynchronization therapy (CRT) is an established treatment of heart failure with reduced EF (HFrEF) and wide QRS complex. Nearly 30% candidates are non-responders. One the suggested mechanisms inadequate response baseline RV function; also effect CRT on right ventricular systolic function has not been well studied. We examined (RV) dimensions overall whether prior to could have impact response. Methods: 30 patients a mean age 51.9 ± 9.2 years including 9 (30%) females,...

Background: Multiple cardiac changes and various abnormalities have been linked to epileptic fits.The assessment of serum biomarkers level are commonly accepted methods evaluate autonomic disturbances during fits which is very closely associated with some cardiovascular events especially the sudden unexpected death. Aim Study:To ictal inter-ictal plasma levels heart type fatty acid binding protein (H-FABP) in pediatric patients treatment resistant epilepsy.Patients Methods: 32 seizure...

Background: Coronary artery disease (CAD) is a paramount cause of death. Global and regional left ventricular (LV) systolic function an important non-invasive marker CAD. We can use tissue Doppler imaging (TDI) to measure the low velocities generated by myocardium which are: S'-wave, E'-wave, A'-wave. aimed examine value S'-wave dispersion TDI across mitral valve annular predict angiographically significant coronary obstruction. Patients Methods: included 100 patients with symptoms...

Objectives: We aimed to investigate the association of major cardiovascular risk factors and severity coronary artery disease (CAD) with vitamin D level. Background: Numerous efforts have been made reduce morbidity mortality, especially in acute syndrome (ACS). However, results are still not optimal. Much consideration is set on revelation new, conceivably modifiable factors. Vitamin deficiency proposed be one such factor, it might related an increased diseases. Methods: conducted a...

Purpose: The SYNTAX Score is a crucial tool to grade angiographic complexity and risk stratification of patients for revascularization. Excessive coronary calcification can lead adverse outcomes after percutaneous intervention (PCI), it represents an essential part score calculation. sensitivity in detecting any CAC by CT much higher than ICA. Our purpose evaluate the impact CT-enhanced calcium detection on evaluation complex anatomy.
 Methodology: This study was conducted at Beni-suef...