A5074909488- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Circular RNAs in diseases
- RNA Research and Splicing
- MicroRNA in disease regulation
- Cancer-related gene regulation
- Tannin, Tannase and Anticancer Activities
- Histone Deacetylase Inhibitors Research
- Medicinal Plant Pharmacodynamics Research
- Wnt/β-catenin signaling in development and cancer
- Adenosine and Purinergic Signaling
- Cancer, Hypoxia, and Metabolism
- Bone Metabolism and Diseases
- Berberine and alkaloids research
- Synthesis and biological activity
- FOXO transcription factor regulation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Mycobacterium research and diagnosis
- Phytase and its Applications
- Protein Hydrolysis and Bioactive Peptides
- Cancer Mechanisms and Therapy
- Cynara cardunculus studies
- Pomegranate: compositions and health benefits
- Mesenchymal stem cell research
- Ferroptosis and cancer prognosis
Guangzhou University of Chinese Medicine
2023-2025
Southern Medical University
2019-2024
Shenzhen Pingle Orthopedic Hospital
2024
Apigenin (API), a natural plant flavone, is abundantly found in common fruits and vegetables. As bioactive flavonoid, API exhibits several activities including antiproliferation anti-inflammation. A recent study showed that could retard osteoporosis progress, indicating its role the skeletal system. However, detailed function mechanism remain obscure. In present study, was to promote osteogenic differentiation of mesenchymal stem cells (MSCs). And further investigation enhance expression...
Abstract Consumption of dietary ellagitannins (ETs) has been proven to benefit multiple chronic health disorders including cancers and cardiovascular diseases. Urolithins, gut microbiota metabolites derived from ETs, are considered as the molecules responsible for these effects. Previous studies have demonstrated that urolithins exhibit antiproliferative effects on prostate, breast, colon cancers. However, hepatocellular carcinoma (HCC), it remains elusive. Herein, we aim investigate...
Aberrant expression of long non-coding RNAs (lncRNAs) has been reported in multiple cancers. However, the underlying mechanisms mediated by super-enhancers remain elusive. Here we sought to define role a novel lncRNA termed lncRNA-DAW tumorigenesis. Our results revealed that was driven liver-specific super-enhancer and transcriptionally activated HNF4G, leading frequent elevation hepatocellular carcinoma (HCC) specimens. Ectopic promoted both vivo vitro tumor growth. By using RNA sequencing,...
Emerging evidence demonstrates that long non-coding RNAs (lncRNAs) play a crucial role in sorafenib resistance hepatocellular carcinoma (HCC), and lncRNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is dysregulated sorafenib-resistant HCC cells. However, the underlying regulatory mechanisms of MALAT1 cells remain unclear. In present study, we demonstrated 5-methylcytosine (m5C) methylation catalyzed by NSUN2 ALYREF contributed to RNA stability upregulation MALAT1. The...
Osteosarcoma (OS) is a common type of malignant bone tumor in adolescents with high risk metastasis. However, the clinical management still remains unsatisfactory. Traditional Chinese medicine (TCM) has been widely considered as an alternative treatment, and their extracts have proved to possess great potential for drug discovery. Baicalein (BA), active pharmaceutical ingredient rhizoma coptidis, was anti-tumor properties OS, but mechanism poorly understood.The anti-cancer effects on cell...
Osteosarcoma (OS) is the most common primary malignancy in bone tissues, and effective therapeutics remain absent clinical practice. Traditional Chinese medicines (TCM) have been used for thousands of years, which provide great insights into OS management. Gallic acid (GA) a natural phenolic enriched various foods herbs. Several pharmacological activities GA such as anti-oxidation anti-inflammation well-established. However, its biological function remains not fully understood. The potential...
Recent evidence underscores the pivotal role of long noncoding RNAs (lncRNAs) in orchestrating bone remodeling and skeletal homeostasis by harmonizing osteoblast osteoclast development. Notably, oncogenic lncRNA, Hottip, implicated osteogenesis regulation, remains insufficiently elucidated. This study aims to delineate Hottip's homeostasis. Hottip knockout mice were generated discern its impact on metabolism. In vitro experiments probed cellular mechanisms influenced while molecular...
As a leading cause of cancer related death in the world, hepatocellular carcinoma (HCC) continues to be attracted various attention recent decades. The traditional Chinese herb has been practiced for thousands years which provides promising potential treatment HCC. Curcumin, bioactive ingredient derived from Curcuma longa, exhibits anti-tumor activity cancers. Although effects Curcumin on HCC elucidated, underlying mechanism remains unclear. In present study, was demonstrated inhibit...
Berberine, a non-prescription medicine clinically applied for diarrhoea and gastroenteritis. Recent studies have demonstrated that it possesses anti-tumour properties in colorectal cancer, but the exact molecular mechanism remains obscure.To elucidate underly mechanisms of berberine cancer from perspective epigenetics, tried to explore role lincROR-Wnt/β-catenin axis induced activity cancer.The effects on cell growth, cycle apoptosis were examined CRC cells. The vivo effect tumour growth was...
Gallic acid (3,4,5-trihydroxybenzoic acid; GA), a natural phenolic acid, is abundantly found in numerous products. Increasing evidence have demonstrated that GA plays anti-cancer roles multiple cancers. However, its anti-tumor effects on hepatocellular carcinoma (HCC) and the underlying mechanism remain obscure. In present study, we suppressed vitro cell viability metastasis inhibited vivo tumor growth of HCC cells. The was further to investigate it showed expression β-catenin led functional...
Colorectal cancer (CRC) is a prevalent form of malignant tumor, and the current clinical treatments are far from satisfactory. Identifying new therapeutic targets therefore essential for practices. The long intergenic non-protein coding RNA lincROR has been shown to play significant role in tumorigenesis various cancers. However, molecular mechanism underlying lincROR-mediated CRC remains unclear. In present study, we found that knockdown significantly inhibited cell viability vitro , while...
Abstract Recent evidence suggests that long noncoding RNAs (lncRNAs) play a crucial role in regulating bone remodeling and skeletal homeostasis by coordinating the development of osteoblasts osteoclasts. Several lncRNAs have been identified to participate formation resorption processes. Among them, well-known oncogenic lncRNA, Hottip, has reported be involved osteogenesis regulation. However, specific function underlying mechanisms remain poorly understood. In this study, we investigated...