A5031008491- Microtubule and mitosis dynamics
- Cancer Genomics and Diagnostics
- Engineering and Material Science Research
- Transportation Safety and Impact Analysis
- Carbohydrate Chemistry and Synthesis
- Genomics and Chromatin Dynamics
- Bacteriophages and microbial interactions
- Chemical Synthesis and Analysis
- Advanced biosensing and bioanalysis techniques
- DNA Repair Mechanisms
- Peptidase Inhibition and Analysis
- Pneumocystis jirovecii pneumonia detection and treatment
- Bacterial Genetics and Biotechnology
- Chromosomal and Genetic Variations
- Pneumonia and Respiratory Infections
- Geological and Geophysical Studies
- Pharmacological Effects and Toxicity Studies
- RNA and protein synthesis mechanisms
- Adenosine and Purinergic Signaling
- Mechanisms of cancer metastasis
- DNA and Nucleic Acid Chemistry
- Streptococcal Infections and Treatments
- Infant Nutrition and Health
- Radiopharmaceutical Chemistry and Applications
- Antibiotic Resistance in Bacteria
University of Edinburgh
2024
Wellcome Centre for Cell Biology
2021-2024
Instituto de Química Física Blas Cabrera
2010-2022
Consejo Superior de Investigaciones Científicas
2010-2022
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias
2010-2022
Instituto de Salud Carlos III
2021
Newcastle University
2020
Synaptonemal complex assembly depends on multivalent protein interactions between SYCE1 and SIX6OS1.
Bacteriophage endolysins include a group of new antibacterials reluctant to development resistance. We present here the first structural study Cpl-7 endolysin, encoded by pneumococcal bacteriophage Cp-7. It contains an N-terminal catalytic module (CM) belonging GH25 family glycosyl hydrolases and C-terminal region encompassing three identical repeats 42 amino acids (CW_7 repeats). These are unrelated choline-targeting motifs in other cell wall produced Streptococcus pneumoniae its...
We have structurally and functionally characterized Skl Pal endolysins, the latter being first endolysin shown to kill effectively Streptococcus pneumoniae , a leading cause of deathly diseases. proved that are cysteine-amidases whose catalytic domains, from CHAP Amidase_5 families, respectively, share an α 3 β 6 -fold with papain-like topology. Catalytic triads identified (for time in family), residues relevant for substrate binding catalysis inferred silico models, including...
Abstract The centromere, defined by the enrichment of CENP-A (a Histone H3 variant) containing nucleosomes, is a specialised chromosomal locus that acts as microtubule attachment site. To preserve centromere identity, levels must be maintained through active loading during cell cycle. A central player mediating this process Mis18 complex (Mis18α, Mis18ý and Mis18BP1), which recruits specific chaperone HJURP to centromeres for deposition. Here, using multi-pronged approach, we characterise...
Abstract Meiotic reductional division is dependent on the synaptonemal complex (SC), a supramolecular protein assembly that mediates homologous chromosomes synapsis and promotes crossover formation. The mammalian SC formed of eight structural components, including SYCE1, only central element with known causative mutations in human infertility. We combine mouse genetics, cellular biochemical studies to reveal SYCE1 undergoes multivalent interactions component SIX6OS1. N-terminus SIX6OS1 binds...