A5014216023- Tryptophan and brain disorders
- Pharmacological Receptor Mechanisms and Effects
- Adenosine and Purinergic Signaling
- Neuroscience and Neuropharmacology Research
- Neural dynamics and brain function
- Photoreceptor and optogenetics research
- Functional Brain Connectivity Studies
- Stress Responses and Cortisol
Southern Medical University
2022
Major depressive disorder (MDD) is a devastating mental that affects up to 17% of the population worldwide. Although brain-wide network-level abnormalities in MDD patients via resting-state functional magnetic resonance imaging (rsfMRI) exist, mechanisms underlying these network changes are unknown, despite their immense potential for depression diagnosis and management. Here, we show astrocytic calcium-deficient mice, inositol 1,4,5-trisphosphate-type-2 receptor knockout mice ( Itpr2 −/−...
Rationale: Stress is a major risk factor for the development of depression.However, underlying molecular mechanisms stress vulnerability in depression are largely uncharacterized.Methods: P2X2 receptors (a receptor gliotransmitter-ATP) medial prefrontal cortex (mPFC) were identified by real-time qPCR, western blots and RNAscope situ hybridization chronic social defeat model (CSDS).We generated conditional knockout mice overexpressed AAV-P2X2 CamkIIα-Cre mice.The depression-like behaviors...
Even though brain-wide network-level abnormalities in major depressive disorder (MDD) patients via resting-state functional MRI (rsfMRI) exist, the mechanisms underlying such network changes are unknown. Here, we show that astrocytic calcium deficient mice, inositol 1,4,5-trisphosphate-type-2 receptor knockout mice (Itpr2-/- mice), display abnormal rsfMRI connectivity (rsFC), which is highly consistent with those of MDD patients. Optogenetic activation medial prefrontal cortex (mPFC)...