A5018682241- Parkinson's Disease Mechanisms and Treatments
- Trace Elements in Health
- Glass properties and applications
- Nuclear Receptors and Signaling
- Iron Metabolism and Disorders
- Regulation of Appetite and Obesity
- Neurological diseases and metabolism
- Biochemical Analysis and Sensing Techniques
- Advancements in Battery Materials
- Alzheimer's disease research and treatments
- Crystallization and Solubility Studies
- Neuroscience and Neuropharmacology Research
- X-ray Diffraction in Crystallography
- RNA regulation and disease
- Nerve injury and regeneration
- Transition Metal Oxide Nanomaterials
- Adipose Tissue and Metabolism
- Advanced Battery Materials and Technologies
- Heavy Metal Exposure and Toxicity
- Boron and Carbon Nanomaterials Research
- Recycling and utilization of industrial and municipal waste in materials production
- Hemoglobinopathies and Related Disorders
- Neurological disorders and treatments
- MXene and MAX Phase Materials
- Surface Modification and Superhydrophobicity
Qingdao University
2016-2025
Affiliated Hospital of Qingdao University
2002-2025
Wuhan University
2008-2025
Renmin Hospital of Wuhan University
2008-2025
Hainan University
2014-2024
Qingdao Municipal Hospital
2024
Cosmetic (Greece)
2024
Yantai University
2014-2023
Fujian Medical University
2023
Hainan Agricultural School
2023
Our objective is to determine the neuromodulatory role of ghrelin in brain. To identify neurons that express receptor [GH secretagogue (GHS-R)], we generated GHS-R-IRES-tauGFP mice by gene targeting. Neurons expressing GHS-R exhibit green fluorescence and are clearly evident hypothalamus, hippocampus, cortex, midbrain. Using immunohistochemistry combination with fluorescent protein fluorescence, identified coexpress dopamine subtype 1 (D1R) GHS-R. The potential physiological relevance...
The gut-derived orexigenic peptide hormone ghrelin enhances neuronal firing in the substantia nigra pars compacta, where dopaminergic neurons modulate function of nigrostriatal system for motor coordination. Here we describe a novel mechanism by which nigral inhibiting voltage-gated potassium Kv7/KCNQ/M-channels through its receptor GHS-R1a and activation PLC-PKC pathway. Brain slice recordings compacta reveal that inhibits native Kv7/KCNQ/M-currents. This effect is abolished selective...
Abstract We recently reported that expression levels of tumor necrosis factor (TNF) receptors, TNFR1 and TNFR2, are significantly changed in the brains cerebrospinal fluid (CSF) with Alzheimer's disease (AD). Moreover, we also found that, an mouse model, genetic deletion TNF receptor (TNFR1) reduces amyloid plaques beta peptides (Aβ) production through β-secretase (BACE1) regulation. TNF-α converting enzyme (TACE/ADAM-17) does not only cleave pro- but however, whether TACE activity was CSF...
Both ghrelin and somatostatin (SST) inhibit glucose-stimulated insulin secretion (GSIS) from pancreatic β-cells, but how these independent actions are regulated has been unclear. The mechanism must accommodate noncanonical receptor (GHS-R1a)-G-protein coupling to Gα(i/o) instead of Gα(q11) dependence on energy balance. Here we present evidence for an equilibrium model heteromerization that fulfills criteria. We show GHS-R1a rather than requires interactions between SST subtype 5 (SST5) in...
Coke-resistant defect-confined Ni-based nanosheet-like catalysts derived from halloysites were developed for CO<sub>2</sub> reforming of methane.