A5087461233- Acute Myeloid Leukemia Research
- Graphene and Nanomaterials Applications
- Epigenetics and DNA Methylation
- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Hemoglobinopathies and Related Disorders
- Advanced Sensor and Energy Harvesting Materials
- Cancer-related gene regulation
- Dielectric materials and actuators
- HIV, Drug Use, Sexual Risk
- HIV/AIDS Research and Interventions
- Conducting polymers and applications
- HIV, TB, and STIs Epidemiology
University of Science and Technology of China
2023-2024
Shandong University
2022-2023
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<div>Abstract<p>Internal tandem duplication (ITD) in the FMS-like receptor tyrosine kinase-3 (FLT3) is one of most frequent mutations acute myeloid leukemia (AML) and associated with poor prognosis. FLT3-ITD result endoplasmic reticulum (ER) retention constitutive autophosphorylation FLT3. The PR/SET domain 16 (PRDM16) highly expressed patients FLT3-ITD<sup>+</sup> AML, suggesting it might play a role leukemogenesis. Here, we revealed that genetic pharmacologic...
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Abstract Despite advances in synthetic vascular grafts, replicating the dynamic biological functions of native microvasculature remains a critical challenge cardiovascular tissue engineering. While polymer-based conduits offer scalability and dimensional versatility, inherent bioinert nature leads to high failure rates < 6 mm diameter applications due thrombotic complications mechanical mismatch with host tissue. Decellularized matrices (dECM) scaffolds emerge as biologically strategic...
For a long time, the potential application of gel-based ionic devices was limited by problem liquid leakage or evaporation. Here, we utilized amorphous, irreversible and reversible cross-linked polyTA (PTA) as matrix lithium bis(trifluoromethane sulfonamide) (LiTFSI) an electrolyte to prepare stretchable (495%) self-healing (94%) solvent-free elastomeric conductor. The liquid-free elastomer can be used stable strain sensor monitor human activities sensitively under extreme temperatures....
Tissue engineering approaches such as the electrospinning technique can fabricate nanofibrous scaffolds which are widely used for small-diameter vascular grafting. However, foreign body reaction (FBR) and lack of endothelial coverage still main cause graft failure after implantation scaffolds. Macrophage-targeting therapeutic strategies have potential to address these issues. Here, we a monocyte chemotactic protein-1 (MCP-1)-loaded coaxial fibrous film with poly(l-lactide-co-ε-caprolactone)...
Objective: To analyze the trajectories of HIV testing self-efficacy among men who have sex with (MSM) based on latent class growth model. Methods: From August 2019 to May 2021, 404 MSM were recruited in Shandong Province and subjected a 1-year follow-up study individual intervention (pushing pictures videos WeChat questionnaires) community (forwarding friends sharing discussing testing-related information groups). The level was measured. long-term trend analyzed using model (LCGM),...
Abstract Internal tandem duplication (ITD) in the FMS-like receptor tyrosine kinase-3 (FLT3) is one of most frequent mutations acute myeloid leukemia (AML) and associated with poor prognosis. FLT3-ITD result endoplasmic reticulum (ER) retention constitutive autophosphorylation FLT3. The PR/SET domain 16 (PRDM16) highly expressed FLT3-ITD+ AML patients, suggesting it might play a role leukemogenesis. Here, we revealed that genetic pharmacological suppression PRDM16 greatly slowed progression...