A5081230016- Functional Brain Connectivity Studies
- Neural dynamics and brain function
- Visual perception and processing mechanisms
- Alzheimer's disease research and treatments
- EEG and Brain-Computer Interfaces
- Context-Aware Activity Recognition Systems
- Vestibular and auditory disorders
- Parkinson's Disease Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Advanced Neuroimaging Techniques and Applications
- Dementia and Cognitive Impairment Research
- Health, Environment, Cognitive Aging
- Amyotrophic Lateral Sclerosis Research
- Advanced MRI Techniques and Applications
- Mobile Health and mHealth Applications
- Obstructive Sleep Apnea Research
- Psychosomatic Disorders and Their Treatments
- Neurological disorders and treatments
- Olfactory and Sensory Function Studies
- Immune cells in cancer
- Neural and Behavioral Psychology Studies
- Stroke Rehabilitation and Recovery
- Memory and Neural Mechanisms
- Infrared Thermography in Medicine
- Neuroscience and Neuropharmacology Research
Bengbu Medical College
2025
Duke University
2025
QIMR Berghofer Medical Research Institute
2014-2024
Powerchina Huadong Engineering Corporation (China)
2020-2024
PowerChina (China)
2020-2024
Biogen (United States)
2021-2024
Southwestern University of Finance and Economics
2024
Beijing University of Technology
2023
Medical Research Institute
2021
Northwestern Polytechnical University
2018-2019
The neural organization of semantic memory remains much debated. A 'distributed-only' view contends that knowledge is represented within spatially distant, modality-selective primary and association cortices. Observations in variant progressive aphasia have inspired an alternative model featuring the anterior temporal lobe as amodal hub supports by linking distributed regions. Direct evidence has been lacking, however, to support intrinsic functional interactions between upstream sensory...
See Schmahmann (doi: 10.1093/brain/aww064 ) for a scientific commentary on this article. Neurodegenerative diseases are associated with distinct and distributed patterns of atrophy in the cerebral cortex. Emerging evidence suggests that these resemble intrinsic connectivity networks healthy brain, supporting network-based degeneration framework where neuropathology spreads across networks. An intriguing yet untested possibility is cerebellar circuits, which share extensive connections...
Abstract Digital clinical measures based on data collected by wearable devices have seen rapid growth in both trials and healthcare. The widely-used wearables are epoch-based physical activity counts using accelerometer data. Even though been the backbone of thousands epidemiological studies, there large variations algorithms that compute their associated parameters—many which often kept proprietary device providers. This lack transparency has hindered comparability between studies different...
Abstract For the last 40 years, actigraphy or wearable accelerometry has provided an objective, low-burden and ecologically valid approach to assess real-world sleep circadian patterns, contributing valuable data epidemiological clinical insights on disorders. The proper use of technology in research requires validated algorithms that can derive outcomes from sensor data. Since publication first automated scoring algorithm by Webster 1982, a variety have been developed contributed research,...
Hexanucleotide repeat expansion in C9orf72 represents the most common genetic cause of familial and sporadic behavioural variant frontotemporal dementia. Previous studies show that some carriers with dementia exhibit distinctive atrophy patterns whereas others mild or undetectable despite severe impairment. To explore this observation, we examined intrinsic connectivity network integrity patients without expansion. We studied 28 dementia, including 14 mutation (age 58.3 ± 7.7 years, four...
Functional connectivity analysis has become a powerful tool for probing the human brain function and its breakdown in neuropsychiatry disorders. So far, most studies adopted resting-state paradigm to examine functional networks brain, thanks low demand high tolerance that are essential clinical studies. However, test-retest reliability of measures is moderate, potentially due behavioral constraint. On other hand, naturalistic neuroimaging paradigms, an emerging approach cognitive...
Convoluted cortical folding and neuronal wiring are 2 prominent attributes of the mammalian brain. However, macroscale intrinsic relationship between these general cross-species attributes, as well underlying principles that sculpt architecture cerebral cortex, remains unclear. Here, we show axonal fibers connected to gyri significantly denser than those sulci. In human, chimpanzee, macaque brains, a dominant fraction were found be gyri. This finding has been replicated in range brains via...
Significance Brain–body interactions are fundamental to physical and mental health. Here, we used a unique brain lesion model elucidate the neural localization lateralization of cerebro-cardiac control. Our data revealed that salience network, an intrinsic connectivity network anchored by anterior insula cingulate, is crucial for maintaining basal parasympathetic outflow. Specifically, dominant hemisphere-predominant damage undermined control heart. The findings suggest balanced functional...
Amyotrophic lateral sclerosis (ALS) is a multifactorial neurodegenerative disease characterised by the loss of upper and lower motor neurons. Increasing evidence indicates that neuroinflammation mediated microglia contributes to ALS pathogenesis. This microglial activation evident in post-mortem brain tissues neuroimaging data from patients with ALS. However, role pathogenesis progression amyotrophic remains unclear, partly due lack model system able faithfully recapitulate clinical...
Abstract Background Alzheimer’s disease (AD) is an incurable neurodegenerative disorder with a rapidly increasing prevalence worldwide. Current approaches targeting hallmark pathological features of AD have had no consistent clinical benefit. Neuroinflammation major contributor to neurodegeneration and hence, microglia, the brain’s resident immune cells, are attractive target for potentially more effective therapeutic strategies. However, there current in vitro model system that captures...
The present study explored the relationship between hearing ability, self-rated health, life satisfaction, and depression among retired middle-aged older adults in China. research was based on data from 2018 China Health Retirement Longitudinal Study (CHARLS). By applying linear regression models, we delved into key factors influencing elderly individuals. We utilized Spearman's rank correlation analysis techniques to reveal interconnections depression, health status, satisfaction....
Progressive supranuclear palsy (PSP) has been conceptualized as a large-scale network disruption, but the specific targeted not fully characterized. We sought to delineate affected in patients with clinical PSP.
Patients with melancholia report a distinct and intrusive dysphoric state during internally generated thought. Melancholia has long been considered to have strong biological component, but evidence for its specific neurobiological origins is limited. The neurocognitive, psychomotor, mood disturbances observed in do, however, suggest aberrant coordination of frontal-subcortical circuitry, which may best be captured through analysis complex brain networks.To investigate the effective...
We sought to explore whether patients with migraine show heightened interictal intrinsic connectivity within primary sensory networks, the salience network, and a network anchored by dorsal pons, region known be active during attacks.Using task-free fMRI region-of-interest analysis, we compared patterns in 15 migraineurs without aura age- sex-matched healthy controls, focusing on networks calcarine cortex, Heschl gyrus, right anterior insula, attacks. also examined relationship between...
Abstract While a rich body of research in controlled experiments has established changes the neural circuitry emotion major depressive disorders, little is known as to how such alterations might translate into complex, naturalistic settings - namely involving dynamic multimodal stimuli with contexts, those provided by films. Neuroimaging paradigms employing natural alleviate anxiety often associated complex tasks and eschew need for laboratory-style abstractions, hence providing an...
Abstract Blind source separation (BSS) is commonly used in functional magnetic resonance imaging (fMRI) data analysis. Recently, BSS models based on restricted Boltzmann machine (RBM), one of the building blocks deep learning models, have been shown to improve brain network identification compared conventional single matrix factorization such as independent component analysis (ICA). These however, trained RBM fMRI volumes, and are hence challenged by model complexity limited training set. In...
Abstract Human interactions with the world are influenced by memories of recent events. This effect, often triggered perceptual cues, occurs naturally and without conscious effort. However, neuroscience involuntary memory in a dynamic milieu has received much less attention than mechanisms voluntary retrieval deliberate purpose. Here, we investigate neural processes driven naturalistic cues that relate to, presumably trigger experiences. Viewing continuation recently viewed clips evokes...
The rate and temporal pattern of neural spiking each have the potential to influence computation. In cerebellum, it has been hypothesized that irregularity interspike intervals in Purkinje cells affects their ability transmit information downstream neurons. Accordingly, during oculomotor behavior mice rhesus monkeys, mean cell varied with eye velocity. However, moment-to-moment variations revealed a tight correlation between velocity spike rate, no additional conveyed by irregularity....