A5084565399- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Graphene and Nanomaterials Applications
- Advanced Nanomaterials in Catalysis
- Immunotherapy and Immune Responses
- Photodynamic Therapy Research Studies
- Extracellular vesicles in disease
- Luminescence and Fluorescent Materials
- Immune cells in cancer
- Micro and Nano Robotics
- Fullerene Chemistry and Applications
- CRISPR and Genetic Engineering
- Neuroinflammation and Neurodegeneration Mechanisms
- Ubiquitin and proteasome pathways
- Microfluidic and Bio-sensing Technologies
- Gut microbiota and health
- Cancer Research and Treatments
- Gold and Silver Nanoparticles Synthesis and Applications
- Crystallization and Solubility Studies
- Organic Light-Emitting Diodes Research
- Marine and fisheries research
- interferon and immune responses
- X-ray Diffraction in Crystallography
Zhengzhou University
2016-2025
Ministry of Education of the People's Republic of China
2022-2025
Chinese Center For Disease Control and Prevention
2022-2025
Ningbo University
2023-2025
Wuxi Fourth People's Hospital
2025
Zhejiang Marine Fisheries Research Institute
2017-2025
Target (United States)
2020-2025
Jiangnan University
2025
Donghua University
2023-2024
Nanjing Medical University
2023-2024
The delivery of probiotics to the microbiota is a promising method prevent and treat diseases. However, oral will suffer from gastrointestinal insults, especially pathological microenvironment inflammatory diseases such as reactive oxygen species (ROS) exhausted mucus layer, which can limit their survival colonization in intestinal tract. Inspired by fact that colonized grew layer under physiological conditions, we developed strategy for super probiotic (EcN@TA-Ca2+@Mucin) coated with tannic...
Despite the promise of tumor starvation therapies, they are often associated with nonspecific and incomplete energy blockade. Here, a novel paradigm therapy is proposed to synergize "Zn
Microglial polarization is one of the most promising therapeutic strategies for multiple central nervous system (CNS) disorders. However, safe, effective, and controllable microglial regulation still faces formidable challenges. Although some anti-inflammatory factors promote microglia polarization, their short half-life, high cost, unpredictable in vivo behavior, complex delivery operations, hamper clinical application. Here, inspired by natural microhemorrhage cleaning mechanism, an MG1...
Abstract Efficient nuclear DNA damage and release is highly recommended to improve the photodynamic immunotherapy by eliciting innate immune response yet remains challenging. Herein, an intracellular self‐assembly driven nucleus‐targeted photo‐immune stimulator (PIS) with chromatin decompaction function reported for adaptive antitumor immunity co‐activation. The PIS consists of vorinostat (SAHA)‐loaded manganese‐porphyrin metal‐organic framework (Mn (III)‐TCPP MOF) further modification...
Breast cancer therapy has always been a hard but urgent issue. Disruption of mitochondrial Ca2+ homeostasis reported as an effective antitumor strategy, while how to contribute overload effectively is critical To solve this issue, we designed and engineered dual enhanced nanogenerator (DECaNG), which can induce elevation intracellular through the following three ways: Calcium phosphate (CaP)-doped hollow mesoporous copper sulfide was basic generate directly persistently in lysosomes (low...
Despite advances in drug delivery systems (DDSs), the stimuli-responsive controlled release DDSs with high spatial/temporal resolution are still best choice. Herein, a novel type of envelope-type mesoporous titanium dioxide nanoparticle (MTN) was developed for one-demand platform. Docetaxel (DTX) loaded pores MTN loading efficiency (∼26%). Then β-cyclodextrin (β-CD, bulky gatekeeper) attached to outer surface via reactive oxygen species (ROS) sensitive linker block (MTN@DTX-CD). MTN@DTX-CD...
Extracellular vesicles (EVs) play important roles in cell-cell communication by transferring cargo proteins and nucleic acids between cells. Due to their small size (50-150 nm) low density, rapid capture nondestructive release of EVs remains a technical challenge which significantly hinders study biofunction biomedical application. To address this issue, we designed DNA aptamer-based system that enabled 90 min with similar isolation efficiency ultracentrifugation (around 78%). Moreover,...
Chemo-immunotherapy holds the advantage of specific antitumor effects by activating T cell immune response. However, efficiency chemo-immunotherapy is restricted to insufficient antigen presentation dendritic cells (DCs) in tumor immunosuppression microenvironment. Here, we rationally designed a simple yet versatile calcium ion nanogenerator disrupt autophagy inhibition condition within DCs, enrich damage-associated molecular patterns (DAMPs), and attenuate acidity After chemotherapy,...
Either hypoxia in an acute ischemic stroke before thrombolysis or the oxygen-boost after cause a high level of free radicals, resulting successive injuries to neurocytes. To treat stroke, it is needed scavenge combining sequentially regulating and microenvironment. Here, we report engineered nanosponge (Mn3O4@nanoerythrocyte-T7, MNET) that could remodel microenvironment by self-adapted oxygen radical scavenging. With long circulation time blood due stealth effect erythrocyte preferential...
Multidrug resistance (MDR) of a tumor is the main cause failure clinical chemotherapy. Herein, we report simple, yet versatile, tumor-targeting "calcium ion nanogenerator" (TCaNG) to reverse drug by inducing intracellular Ca2+ bursting. Consequently, TCaNG could induce bursting in acidic lysosomes cells and then according following mechanisms: (i) specifically accumulates mitochondria, suppressing cellular respiration relieving hypoxia, thus inhibiting P-glycoprotein biosynthesis...
Extracellular vesicles (EV) have attracted increasing attention as tumour biomarkers due to their unique biological property. However, conventional methods for EV analysis are mainly based on bulk measurements, which masks the EV-to-EV heterogeneity in diagnosis and classification. Herein, a localized fluorescent imaging method (termed Digital Profiling of Proteins Individual EV, DPPIE) was developed multiple proteins individual EV. In this assay, an anti-CD9 antibody engineered biochip used...
Following ischemic stroke, brain-resident activated microglia and peripherally infiltrated inflammatory cells create a complicated overactivated brain immune microenvironment, which causes neuron death dramatically hinders neurological functional recovery. Herein, an engineering CXCL12 biomimetic decoy-integrated versatile immunosuppressive nanoparticle (VIN) for management of the microenvironment is reported. The shell VIN (membrane CXCR4 overexpressed mesenchymal stem cells), can not only...