A5002751587- Distributed and Parallel Computing Systems
- Cardiomyopathy and Myosin Studies
- Mobile Agent-Based Network Management
- Scientific Computing and Data Management
- Service-Oriented Architecture and Web Services
- Advanced Data Storage Technologies
- Advanced Database Systems and Queries
- Statistical Methods and Inference
- Congenital heart defects research
- Business Process Modeling and Analysis
- Mobile Ad Hoc Networks
- Gene expression and cancer classification
- Advanced Causal Inference Techniques
- Statistical Methods in Clinical Trials
- Vehicular Ad Hoc Networks (VANETs)
- Health, Environment, Cognitive Aging
- Genomics and Rare Diseases
- Opportunistic and Delay-Tolerant Networks
- Cardiac electrophysiology and arrhythmias
- Trypanosoma species research and implications
- Healthcare Systems and Practices
- Software-Defined Networks and 5G
- Genomic variations and chromosomal abnormalities
- Parallel Computing and Optimization Techniques
- Network Traffic and Congestion Control
Universidade da Coruña
2004-2023
Research Institute Hospital 12 de Octubre
2023
Centro de Supercomputación de Galicia
2014-2022
Epidemiologists increasingly use causal inference methods that rely on machine learning, as these approaches can relax unnecessary model specification assumptions. While deriving and studying asymptotic properties of such estimators is a task usually associated with statisticians, it useful for epidemiologists to understand the steps involved, are often at forefront defining important new research questions translating them into parameters be estimated. In this paper, our goal was provide...
Abstract Dilated cardiomyopathy (DCM) is a major cause of heart failure (HF) defined by ventricular dilatation and systolic dysfunction. Although microRNAs (miRNAs) are known to affect HF development, little about the contribution genetic variants in miRNAs or their precursors susceptibility pathogenesis DCM. We screened 1640 DCM cases for cardiac miR-208a miR-208b precursors. identified four pre-miRNA, which present at very low frequencies general population. Two these (+42G > T +68G...
The management and monitoring of static dynamic resources is a key issue in grid environments. Information models are an abstract representation software hardware aspects these resources, common structured that allows intra- inter-grid interoperability. Among them, the information model (CIM), standardized by DMTF, object-oriented extensible model. aim this work to provide CIM-based query service for resource systems. This achieved publishing CIM on discovery system version 4 (MDS4)...
The need of task-adapted and complete information for the management resources is a well known issue in Grid computing. Globus Toolkit 4 (GT4) includes Monitoring Discovery System component (MDS4) to carry out resource management. Common Information Model (CIM) provides standard conceptual view managed environment. This work improves MDS4 functionality through use CIM, with aim providing unified, representation resources. Since practical CIM model may contain large volume information, new...
Abstract Background Copy number variations (CNVs) have increasingly been recognized in the cardiovascular setting. Their role hypertrophic cardiomyopathy or sudden cardiac death has described, but their involvement Long QT syndrome (LQTS) scarcely studied. Most of these descriptions are confined to case reports small series. Purpose The aim this study is investigate proportion clinically relevant CNVs among a large cohort index cases referred for genetic testing due LQTS. Methods...
Abstract Background Diagnostic yield in long QT syndrome (LQTS) ranges between 30-70%, depending on the studied population. LQTS can lead to an unexpected sudden cardiac death. For this reason and due its wider current availability, genetic testing patients with suspicion of has spread. Purpose The aim study is investigate among a large cohort heterogeneous index cases phenotype. Methods was restrospectively evaluated referred our laboratory for Genetic performed customized libraries through...
Computer networks and large-scale systems are growing becoming increasingly hard to manage, specially in the software front, but also hardware, their management information more complicated integrate a seamless manner. This paper presents framework that a) allows extraction of configuration from its original format, b) models it (including relations inheritance) via CIM object-oriented model, c) persists retrieves transparently, independently repository, retaining schema constraints. These...
Abstract Background/Introduction Dilated cardiomyopathy (DCM) is one of the most common cardiomyopathies, with a prevalence 1 in 250. Single nucleotide variants (missense, nonsense, or frameshift) definitive DCM genes are frequently identified positive genetic studies. Despite major advances diagnostic technologies recent decades, and more than 100 potentially associated to date, yield still lower 40%. Copy number (CNVs) have been as cause disease several studies, especially intolerant...
Platform trials are multi-arm designs that simultaneously evaluate multiple treatments for a single disease within the same overall trial structure. Unlike traditional randomized controlled trials, they allow treatment arms to enter and exit at distinct times while maintaining control arm throughout. This comprises both concurrent controls, where participants concurrently either or arm, non-concurrent who when under study is unavailable. While flexible, platform introduce unique challenge...
Difference-in-differences is based on a parallel trends assumption, which states that changes over time in average potential outcomes are independent of treatment assignment, possibly conditional covariates. With time-varying treatments, assumptions can identify many types parameters, but most work has focused group-time effects and similar parameters the trajectory. This paper focuses instead identification estimation intervention-specific mean - outcome had everyone been exposed to...
Provider profiling has the goal of identifying healthcare providers with exceptional patient outcomes. When evaluating providers, adjustment is necessary to control for differences in case-mix between different providers. Direct and indirect standardization are two popular risk methods. In causal terms, direct examines a counterfactual which entire target population treated by one provider. Indirect standardization, commonly expressed as standardized outcome ratio, provider had instead been...
The task of TNO is to provide predictions the scalability and performance new all-IP tactical networks Royal Netherlands Army (RNLA) that are likely be fielded. inherent properties fielded networks, such as low bandwidth quality service (QoS) policies require models key network devices that, under similar traffic conditions, accurately simulate behavior they represent. uses OPNET for modeling military communication networks. However, validation reports standard provided by OPNET, or...
Abstract Introduction ALPK3 null variants (ALPK3nv) in simple heterozygosis represent an established and emerging genetic cause for hypertrophic cardiomyopathy. Some studies have indicated that this substrate would be associated with a disease of late-onset incomplete penetrance. Purpose To perform extended genotype-phenotype correlation analysis respect to heterozygous ALPK3nv carriers, focusing on age at diagnosis, maximum wall thickness survival analysis, performed the largest available...
Abstract Background Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiac disorder, with a prevalence between 1/250-500 individuals. The yield of genetic testing for this condition stands at 40%. prevalent genes are MYBPC3 and MYH7, small contributions other genes, such as TNNT2, TNNI3, TPM1, MYL2 or FHOD3. At our center, we have identified recurrent variant in p.Asn271Ile, associated HCM. Most probands came from northwest Spain (Galicia), which suggested that they may share...
Abstract Introduction MYH7 encodes to β-cardiac myosin heavy chain, a large and pleomorphic protein, conformed by different well-functionally characterized domains. This gene has an enormous contribution hypertrophic cardiomyopathy (HCM) but also other cardiomyopathies such as dilated, non-compaction restrictive (and overlapping phenotypes). There are specific adapted recommendations for classifying variants in this regarding its association with HCM; one of the aspects was location head...