A5015425761- Phytochemistry and Biological Activities
- Tunneling and Rock Mechanics
- Drilling and Well Engineering
- Virus-based gene therapy research
- Rock Mechanics and Modeling
- Grouting, Rheology, and Soil Mechanics
- Cancer Research and Treatments
- Bamboo properties and applications
- Geotechnical Engineering and Analysis
- Tree Root and Stability Studies
- Geotechnical Engineering and Underground Structures
- Natural Fiber Reinforced Composites
- Cancer, Hypoxia, and Metabolism
- Polysaccharides Composition and Applications
- RNA Interference and Gene Delivery
- Leaf Properties and Growth Measurement
- Coconut Research and Applications
- Flowering Plant Growth and Cultivation
- Lipid metabolism and biosynthesis
- Wnt/β-catenin signaling in development and cancer
- interferon and immune responses
- Forest, Soil, and Plant Ecology in China
- Seed and Plant Biochemistry
- Antiplatelet Therapy and Cardiovascular Diseases
- Medicinal Plants and Bioactive Compounds
Southwest Jiaotong University
2019-2024
Anhui Agricultural University
2023-2024
International Bamboo and Rattan Organization
2023-2024
State Forestry and Grassland Administration
2023-2024
Shijiazhuang Tiedao University
2024
Ministry of Transport
2022
Center for Excellence in Molecular Cell Science
2011-2020
Chinese Academy of Sciences
2011-2020
Shanghai Institutes for Biological Sciences
2011-2020
Institute of Cell Biology
2020
Abstract Metabolic enzymes and metabolites display non-metabolic functions in immune cell signalling that modulate attack ability. However, whether how a tumour’s metabolic remodelling contributes to its resistance remain be clarified. Here we perform functional screen of genes rescue tumour cells from effector T cytotoxicity, identify the embryo- tumour-specific folate cycle enzyme methylenetetrahydrofolate dehydrogenase 2 (MTHFD2). Mechanistically, MTHFD2 promotes basal IFN-γ-stimulated...
Bamboo is a naturally occurring composite material, which exhibits decomposable structure with varying composition. The distinct structural features of bamboo contribute to its exceptional strength and flexibility, making it an excellent choice for construction purposes. However, only limited portion species has been studied mechanical properties, research on Bambusa arundinaceae primarily focused pharmaceutical values. Therefore, we investigated the relationship between characteristics B....
Lung cancer remains one of the most common cancer-associated mortalities worldwide, and platinum-based doublet chemotherapies are recommended as first‑line treatment for advanced non‑small cell lung (NSCLC). However, frequent development multidrug resistance, to cisplatin regimens in particular, is a major cause chemotherapy failure patients with aggressive NSCLC. Wnt/β‑catenin signaling sex‑determining region Y box 2 (Sox2) have been implicated progression resistance epidermal growth factor...
The development of chemoresistance to cisplatin regimens causes a poor prognosis in patients with advanced NSCLC. role noncanonical Wnt signaling the regulation properties lung cancer stem cells and was interrogated, by accessing capacities cell proliferation, migration, invasion, clonogenicity as well apoptosis A549 lines cisplatin-resistant treated Wnt5a conditional medium or protein kinase C (PKC) inhibitor GF109203X. Results showed that ligand, Wnt5a, could promote colony formation...
Cancer Targeting Gene-Viro-Therapy (CTGVT) is a promising cancer therapeutical strategy that strengthens the anti-tumour effect of oncolytic virus by expressing inserted foreign genes. In this work, we constructed novel adenoviral vector controlled tumour-specific survivin promoter on basis ZD55 vector, which an E1B55KD gene deleted previously constructed. Compared with original new (ZD55SP/E1A) showed much better ability replication and reporter expression. We then combined interleukine-24...
To investigate the therapeutic effect of allopurinol treatment on acute coronary syndrome and to elucidate its possible mechanism.Patients with (n = 100) were recruited as research subjects in our hospital. The patients randomly divided into two groups, an group 50) a control 50). These groups treated conventional antiplatelet, anticoagulation anti-ischemic therapy; therapy was added based indications. Biochemical markers such serum creatinine, uric acid, BNP, blood glucose lipid compared...
Abstract The M2 isoform of pyruvate kinase (PKM2) is a key driver glycolysis in cancer cells and has critical ‘non-metabolic’ functions some cancers; however, the role PKM2 pancreatic remains unclear. aim current study was to elucidate progression potential as therapeutic target. In this study, we observed that highly expressed patients with correlated survival. Elevated expression promoted cell proliferation, migration tumor formation. inhibition growth by silencing caused impairment...
Biosilicified oncolytic adenovirus (OAs) significantly improved OAs distribution and tumor inhibition <italic>in vivo.</italic>
Calamus caesius, one of the most valuable high-quality rattans, has emerged as an economical material for use in commercial products. This study systematically investigated anatomical and microstructural characteristics caesius terms frequency, radial diameter, tangential form factor vascular bundles both inner outer regions, well proportion, length, length-diameter ratio vessel elements, size, double wall thickness, lumen ultrastructure fibers. The results revealed that sizes elements...
Cancer Targeting Gene-Viro-Therapy (CTGVT) is constructed by inserting an antitumor gene into oncolytic virus (OV). It actually OV-gene therapy, which has much better effect than either therapy alone or virotherapy in our previously published papers. This study a modification of CTGVT colorectal cancer (CRC) specific suppressor gene, ST13, CRC virus, the Ad·CEA·E1A(Δ24), to construct Ad·(ST13)·CEA·E1A(Δ24) for increasing targeting tropism and it was briefly named as CTGVT-CRC. Although many...
The ZD55-tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and ZD55-interleukin (IL)-24 were constructed by inserting TRAIL or IL-24 gene separately into the oncolytic adenovirus named ZD55 (with E1B-55kD deletion). resulting ZD55-TRAIL ZD55-IL-24 used in combination to treat xenograft tumors nude mice model. results showed that it can not only completely eliminate BEL7404 hepatoma but also have excellent antitumor effect against gaster, lung, prostate, breast carcinomas. It...