Luke D. Mascarenhas
A5055530529- Computational Drug Discovery Methods
- Neurological Disorders and Treatments
- Phosphodiesterase function and regulation
- Synthesis and biological activity
- Bone Tumor Diagnosis and Treatments
- Spine and Intervertebral Disc Pathology
- Pelvic and Acetabular Injuries
- Synthesis and Reactions of Organic Compounds
- Scoliosis diagnosis and treatment
- Inflammatory mediators and NSAID effects
- Cardiac tumors and thrombi
- Enzyme function and inhibition
- Sarcoma Diagnosis and Treatment
- Vitamin K Research Studies
- Protein Kinase Regulation and GTPase Signaling
Baylor Scott & White Medical Center - Temple
2024
The University of Texas Southwestern Medical Center
2019-2023
Baylor University Medical Center
2022
Southwestern Medical Center
2019-2021
The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. provides concise overviews, mostly tabular format, key properties nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links open access knowledgebase source and their ligands (www.guidetopharmacology.org), which more detailed views target ligand properties. Although constitutes over 500 pages, material presented substantially reduced compared...
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. provides concise overviews, mostly tabular format, key properties approximately 1800 drug targets, and about 6000 interactions with 3900 ligands. There an emphasis on selective pharmacology (where available), plus links open access knowledgebase source targets their ligands ( www.guidetopharmacology.org ), which more detailed views target ligand properties. Although constitutes almost 500 pages,...
Synovial sarcoma, a rare soft tissue malignancy, predominantly affects adolescents and young adults, with predilection for extremities. We present the case of 19-year-old woman rapidly growing left shoulder synovial initially managed neoadjuvant chemotherapy to reduce tumor size. Subsequently, she underwent radical surgical resection, necessitating complex anatomical dissection due involvement extending into coracoid deltoid. Given limitations in current literature regarding reconstructive...
Regulator of G protein Signaling, or RGS, proteins serve an important regulatory role in signaling mediated by protein-coupled receptors (GPCRs). They all share a common RGS domain that directly interacts with active, GTP-bound Gα subunits heterotrimeric proteins. stabilize the transition state for GTP hydrolysis on and thus induce conformational change subunit accelerates hydrolysis, thereby effectively turning off cascades GPCRs. This GTPase accelerating (GAP) activity is canonical...
Regulators of G protein signalling (RGS) proteins display a common RGS domain that interacts with the GTP-bound Gα subunits heterotrimeric proteins, enhancing GTP hydrolysis by stabilising transition state [29, 419, 418], leading to termination GPCR signalling. Interactions through protein:protein interactions many have been identified for targets other than heteromeric proteins. Sequence analysis 20 suggests four families RGS: RZ, R4, R7 and R12 families. Many these effects targetting...
Regulator of G protein Signaling, or RGS, proteins serve an important regulatory role in signaling mediated by protein-coupled receptors (GPCRs). They all share a common RGS domain that directly interacts with active, GTP-bound Gα subunits heterotrimeric proteins. stabilize the transition state for GTP hydrolysis on and thus induce conformational change subunit accelerates hydrolysis, thereby effectively turning off cascades GPCRs. This GTPase accelerating (GAP) activity is canonical...
Regulator of G protein Signaling, or RGS, proteins serve an important regulatory role in signaling mediated by protein-coupled receptors (GPCRs). They all share a common RGS domain that directly interacts with active, GTP-bound Gα subunits heterotrimeric proteins. stabilize the transition state for GTP hydrolysis on and thus induce conformational change subunit accelerates hydrolysis, thereby effectively turning off cascades GPCRs. This GTPase accelerating (GAP) activity is canonical...