Introduction. Immune memory is a tool of the adaptive immune system that allows it responding quickly and effectively to repeated contact with an antigen. The role cell populations in recurrence progression immune-dependent diseases shown. Aim. To determine trend T-cell depending on effectiveness biological therapy (BT) children inflammatory bowel disease (IBD), multiple sclerosis (MS) psoriasis (PS). Materials methods. Four hundred fifty immunosuppressive (ISD) were examined during...

Introduction. The advent of pathogenetic therapy has significantly changed the prognosis for spinal muscular atrophy (SMA). However, our knowledge methods treating SMA is mostly based on results clinical trials, which are largely limited due to narrow criteria selecting patients and short duration following-up. Objective. To evaluate efficacy onasemnogene abeparvovec gene in with type I manifestations disease children at presymptomatic stage real practice. Materials methods. study included...

Introduction. Cytokines (CC) play an important pathogenetic role in the development of autoimmune diseases. Over past decade, there has appeared a huge number biological drugs that target certain cytokines. The main problem remains choice suitable drug, as up to 40% patients do not respond treatment or become resistant it. Aim: identify informative cytokine complexes children with psoriasis, MS, and IBD different efficacy therapy. Materials methods. Two hundred eighty eight diseases were...

Multiple sclerosis (MS) is a rare neuroinflammatory and neurodegenerative disease that leads to disability significant decrease in the quality of life. Over past decade, focus studies MS disease-modifying therapies (DMT) adults have significantly changed highly effective drugs at early stages disease; pediatric patients, safer, but less DMTs are preferred. 
 Today, only two (fingolimod teriflunomide) investigated over large phase III were approved by regulatory authorities for use...

Multiple sclerosis (MS) is a chronic, demyelinating disease that leads to disability. Understanding the etiology of MS contributes development pathogenetic methods treatment, and search for informative biomarkers effectiveness treatment will allow patient adjust therapy in time. The aim this work was determine cytokines cytokine profiles predict IFN-β1a children with MS. Materials . 66 aged 16 [14.2–17.5] years who are on INFß-1a were examined: group 1 — patients exacerbation (with active...

Children with chronic neurological pathology are at risk for the development of severe infectious diseases, but despite this, there is a poor coverage preventive vaccinations in this category children worldwide. For modern vaccine preparations, presence conditions not contraindication to administration. There only two reasons why vaccination should be postponed or drug replaced. These contraindications administration live vaccines receiving immunosuppressive therapy, and whole-cell pertussis...

In recent decades, there has been an increase in the incidence of autoimmune diseases (AID) among adults and children. The immunopathogenesis AID is based on imbalance between autoaggressive regulatory cells (Tregs), which regulated by metabolic signaling pathways cytokine microenvironment. Understanding mechanisms immunometabolism opens up new possibilities for treatment patients with AID. aim was to evaluate activity lymphocyte dehydrogenases associated OXPHOS glycolysis, depending level...

Genetically engineered biological preparations (GEBP) are successfully used in various immunosuppressive diseases. Despite the effectiveness of GEBP, some patients experience primary non-response, as well loss effect from therapy. There is a need to objectively assess therapy for its timely correction. The aim work was determine survival rate GIBP depending on form pathology, drug, age, and immune indices children with Crohn’s disease (CD), ulcerative colitis (UC), psoriasis (PS), multiple...

MS is a common disease of the central nervous system that leads to disability and reduced quality life. The debut in 3-5% patients occurs childhood has less favorable course compared adults. caused by activation autoreactive T cells breakdown peripheral tolerance, which normally controlled regulatory (Tregs). It promising study expression CD39 CD73 Treg Th17 populations assess their suppressive activity. Aim evaluate content major minor lymphocyte CD4 + population children with MS. 111 were...

Metabolic aberrations underlie many chronic diseases, including autoimmune diseases (AUD). Immune metabolism is an area of immunological research that actively developing and studying the processes metabolic reprogramming in immune cells. The regulation nuclear factor kappa B (NF-κB) activity, which involved coordination innate adaptive immunity, inflammatory reactions other processes, being studied. studies on NF-κB a promising direction searching for new therapeutic approaches AUD...

The article presents hormonal analysis of hypothalamus–hypophysis–ovaries system 14 pa-tients with sterility as well other 15 patients without suffering from benign tumors or tumorous formations. control group included 6 healthy women. concentration hormones in blood serum (FSH-follicle stimulating hormone, LH-lutein Prolactinum, Testosteronum, Oestradiolum, Progesterone) has been tested dynamics a menstrual cycle. Correlation results and histological capsule formation biopsy tissue an ovary...

Chronic inflammatory demyelinating polyneuropathy (CIDP) in children is a rare disease, the genesis of which autoimmune disorders. In CIDP, processes are mediated by disorders both cellular and humoral links immune system. Manifestations demyelination can be observed on any segment peripheral nerve from spinal roots to its distal parts. Currently, there typical CIDP variants. The diagnosis based results analysis patient’s anamnesis, neurological examination electromyography (EMG) data,...

Levamizole is an imidazole derivative used in the treatment of various types cancer, dermatological diseases and parasitoses. The drug has immunomodulatory properties due to stimulating activity macrophages, neutrophils, monocytes T-lymphocytes. Common side effects are gastrointestinal disorders, skin manifestations hematological disorders. There also a wide range neurological effects, such as headache, dizziness, vomiting, aphasia, blurred vision, diplopia, weakness, which can be observed...

Myeloid-derived suppressor cells (MDSCs) play an important role in regulation of immune response. An increase their number adult patients with autoimmune diseases has been reported. G-MDSCs, M-MDSCs, and MDSCs(M-G-) at different stages disease may both activate T cell proliferation, leading to progression, or inhibit it, thus promoting Treg differentiation. Arginase-1 (Arg- 1) is enzyme MDSCs that reduces the concentration arginine required for lymphocyte proliferation. Our aim was evaluate...

Juvenile amyotrophic lateral sclerosis (ALS) is a rare group of motor neuron diseases, with the age onset up to 25 years. ALS more commonly has genetic origin vs. sporadic forms that develop in adulthood. Genetic analysis these cases early makes it possible identify genes responsible for disease. Here we present case variant juvenile caused due SPTLC2 gene mutation.
 Cases disease are characterized by slow progression and variable phenotype, which often accurate diagnosis challenging....

Goal. To evaluate the safety profile of onasemnogene abeparvovec (Zolgensma®) gene therapy in children with spinal muscular atrophy (SMA) real clinical practice. Materials and methods. The study included 30 SMA who underwent replacement from December 2020 to 2021 at Center for Pediatric Psychoneurology. All had a diagnosis confirmed by molecular genetic methods, no more than 3 copies SMN2 absence antibodies adeno-associated virus serotype 9. was assessed monitoring laboratory data patients...

Background: Chronic lymphocytic inflammation with perivascular contrast enhancement in the pons responsive to steroids (CLIPPERS) is a rare and relatively new pathology magnetic resonance imaging (MRI) highly important its diagnosis. Clinical case description: The analysis of MRI results revealed typical changes characteristic CLIPPERS, such as contrast-positive small-point curvilinear lesions pons, medulla oblongata midbrain, well cerebral peduncles cerebellum. In addition we described,...