A5051593695- Genetics, Aging, and Longevity in Model Organisms
- Circadian rhythm and melatonin
- Genomics and Chromatin Dynamics
- RNA modifications and cancer
- Advanced biosensing and bioanalysis techniques
- Signaling Pathways in Disease
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- RNA Research and Splicing
- Spaceflight effects on biology
- Heat shock proteins research
- Peptidase Inhibition and Analysis
Friedrich Miescher Institute
2020-2025
C. elegans develops through four larval stages that are rhythmically terminated by molts, is, the synthesis and shedding of a cuticular exoskeleton. Each cycle involves rhythmic accumulation thousands transcripts, which we show here relies on transcription. To uncover responsible gene regulatory networks (GRNs), screened for transcription factors promote progression identified GRH-1, BLMP-1, NHR-23, NHR-25, MYRF-1, BED-3. We further characterize Grainyhead/LSF factor, whose orthologues in...
The mammalian PAS-domain protein PERIOD (PER) and its
Summary Small RNA pathways defend the germlines of animals against selfish genetic elements and help to maintain genomic integrity. At same time, their activity needs be well-controlled prevent silencing ‘self’ genes. Here, we reveal a proteolytic mechanism that controls endogenous small interfering (22G) in Caenorhabditis elegans germline protect genome integrity fertility. We find WAGO-1 WAGO-3 Argonaute (Ago) proteins are matured through processing unusually proline-rich N-termini. In...
Abstract Molting, that is, the synthesis and shedding of a cuticular exoskeleton, is defining characteristic ecdysozoa. In nematodes such as C. elegans , molts rhythmically terminate each four larval stages. The molting cycle tightly coupled to rhythmic accumulation thousands transcripts. Here, using chromatin immunoprecipitation sequencing (ChIP-seq) quantitative reporter assays, we show these dynamic gene expression patterns rely on transcription. To gain insight into relevant regulatory...