A5102809109- Neonatal Respiratory Health Research
- Birth, Development, and Health
- Nutritional Studies and Diet
- Pregnancy and preeclampsia studies
- Colorectal Cancer Screening and Detection
- Sodium Intake and Health
- Congenital Heart Disease Studies
- Gastroesophageal reflux and treatments
- Vitamin C and Antioxidants Research
- Health and Medical Research Impacts
- Blood Pressure and Hypertension Studies
- Renal function and acid-base balance
- Gastric Cancer Management and Outcomes
- Gestational Diabetes Research and Management
- Complementary and Alternative Medicine Studies
- Cardiac Arrhythmias and Treatments
- Esophageal Cancer Research and Treatment
- Diet and metabolism studies
- Opioid Use Disorder Treatment
- Eosinophilic Esophagitis
- Multiple Sclerosis Research Studies
- Cardiac electrophysiology and arrhythmias
- Health Sciences Research and Education
- Climate Change and Health Impacts
- Tracheal and airway disorders
Oregon Health & Science University
2015-2025
Oregon Clinic
2014-2025
London Health Sciences Centre
2025
Saint Louis University
2017-2025
Oregon National Primate Research Center
2014-2023
Indiana University – Purdue University Indianapolis
1989-2023
Portland State University
2017-2023
UCLouvain Saint-Louis Brussels
2023
Doernbecher Children's Hospital
2022
UCSF Benioff Children's Hospital
2022
A data base of the National Center for Health Statistics, and Nutrition Examination Survey I (HANES I), was used to perform a computer-assisted, comprehensive analysis relation 17 nutrients blood pressure profile adult Americans. Subjects were 10,372 individuals, 18 74 years age, who denied history hypertension intentional modification their diet. Significant decreases in consumption calcium, potassium, vitamin A, C identified as nutritional factors that distinguished hypertensive from...
Previous trials have suggested that calcium supplementation during pregnancy may reduce the risk of preeclampsia. However, differences in study design and a low dietary intake populations studied limit acceptance data.
ContextClinical studies of omega-3 polyunsaturated fatty acids (PUFAs) have shown a reduction in sudden cardiac death, suggesting that PUFAs may antiarrhythmic effects.ObjectiveTo determine whether beneficial effects patients with history sustained ventricular tachycardia (VT) or fibrillation (VF).Design and SettingRandomized, double-blind, placebo-controlled trial performed at 6 US medical centers enrollment from February 1999 until January 2003.PatientsTwo hundred an implantable...
A pilot survey was made of the dietary calcium intake normotensive and hypertensive individuals. Compared to 44 controls, 46 subjects with essential hypertension reported significantly less daily ingestion (668 ± 55 milligrams compared 886 89 milligrams). The other nutrients, including sodium potassium, very similar in two groups. hypertensives differed from controls primarily their consumption nonfluid dairy products. data suggest that inadequate may be a previously unrecognized factor...
Maternal smoking during pregnancy adversely affects offspring lung development, with lifelong decreases in pulmonary function and increased asthma risk. In a primate model, vitamin C blocked some of the in-utero effects nicotine on development function.To determine if newborns pregnant smokers randomized to receive daily would have improved results tests (PFTs) decreased wheezing compared those placebo.Randomized, double-blind trial conducted 3 sites Pacific Northwest between March 2007...
Extended continuous positive airway pressure (eCPAP) in the neonatal intensive care unit (NICU) for stable preterm infants increases lung volumes. Its effect on growth after discharge is unknown. To assess whether 2-weeks of eCPAP associated with increased alveolar volume (VA) at 6-months corrected age. Randomized controlled trial conducted Oregon Health & Science University. Outpatient assessors unaware treatment assignment. 100 randomized to versus CPAP discontinuation (dCPAP) room air....
<h3>Background:</h3> Recent reports have identified mutations in the transcription factor <i>GATA4</i> familial cases of cardiac septal defects. The prevalence population patients with defects is unknown. Given that and conotruncal defect can share a common genetic basis, it unclear whether additional types CHD might also mutations. <h3>Aims:</h3> To explore these questions by investigating large 628 either or for sequence variants. <h3>Methods:</h3> coding region exon–intron boundaries were...
OLORECTAL CANCER INCIdence and mortality are higher in black patients compared with white patients.Mortality rates for men (34.3 per 100 000 population year) women (24.5 38% to 43% than women. 1 Incidence 15.5% 23% individuals. 1Since 1985 as incidence have declined individuals by 20% 25%, increased remained unchanged There many possible reasons these differences.Factors such poor access care, failure of health care professionals recommend screening, lower participation when screening is...
Context.—The incidence of infective endocarditis after surgical repair congenital heart defects is unknown.Objective.—To determine the long-term any 12 in childhood.Design.—Population-based registry started 1982.Setting.—State Oregon.Participants.—All Oregon residents who underwent for 1 major at age 18 years or younger from 1958 to present.Main Outcome Measure.—Diagnosis confirmed by hospital autopsy records.Results.—Follow-up data were obtained 88% this cohort 3860 individuals through...
Objective . To assess reliability, validity, and responsiveness of a 29-item short-form version the Patient Reported Outcomes Measurement Information System (PROMIS) novel "impact score" calculated from those measures. Design Prospective cohort study. Setting Rural primary care practices. Subjects Adults aged ≥ 55 years with chronic musculoskeletal pain, not currently receiving prescription opioids. Methods completed PROMIS short form at baseline after 3 months. subsets were compared to...
Infants whose mothers smoked during pregnancy demonstrate lifelong decreases in pulmonary function. DNA methylation changes associated with maternal smoking have been described placenta and cord blood at delivery, fetal lung, buccal epithelium childhood. We demonstrated a randomized clinical trial ( ClinicalTrials.gov identifier, NCT00632476) that vitamin C supplementation to pregnant smokers can lessen the impact of on offspring function decrease incidence wheeze 1 year age.To determine...
Christina Szperka: Has received grant support from Pfizer and Amgen. Juliana VanderPluym: Reports speaking fees for Amgen Novartis, consulting Healint. Serena L. Orr: Receives royalties Cambridge University Press. Christopher Oakley: None. William Qubty: Irene Patniyot: Ana Marissa Lagman-Bartolome: Is on the advisory board Teva, Allergan speakers’ bureau Aralez. Cynthia Morris: Jessica Gautreaux: Speaker’s Supernus has travel funds American Academy of Neurology. M. Cristina Victorio:...
In large, prospective studies of pregnancy conducted in the 1960s, women reported very accurately whether or not they smoked. However, 1990s, pregnant who smoke are often pressured to reduce quit smoking, and incentive misreport may be greater than past. To assess accuracy authors compared self‐reported smoking with cotinine serum and/or urine 105 participated Calcium for Pre‐eclampsia Prevention pilot study 1992. Cotinine confirmed report 84.6% 94.5% denied smoking. These fractions...
Lipoic acid (LA) is an antioxidant that suppresses and treats animal model of multiple sclerosis (MS), experimental autoimmune encephalomyelitis. The purpose this study was to determine the pharmacokinetics (PK), tolerability effects on matrix metalloproteinase-9 (MMP-9) soluble intercellular adhesion molecule-1 (sICAM-1) oral LA in patients with MS. Thirty-seven MS subjects were randomly assigned one four groups: placebo, 600 mg twice a day, 1200 once day day. Subjects took capsules for 14...