Purpose : to develop easy-to make and reproducible models of retinal pigment epithelium atrophy (RPE) degeneration using two types solution (0.9 % sodium chloride bevacizumab) evaluate these clinical instrumental pathomorphological studies. Material methods . To create the models, we used 60 New Zealand albino rabbits divided into 2 groups 30 animals each (30 eyes). In group 1, 0.01 ml 0.9 was delivered subretinal space at a distance 1–1.5 mm downwards from optic disc forming bladder, whilst...

Purpose : to evaluate the effectiveness of surgical treatment floppy eyelid syndrome. Material and methods. The clinical group consisted 23 patients (46 eyes) with syndrome (16 men 4 women), ave. aged 46,0 ± 2.6 years. Of these 20 underwent surgery for by vertical horizontal shortening upper or without correction blepharoptosis. observation period ranged from 1 month 10 Fragments resected during operation were subjected histological examination. Results . A study revealed a reduced quantity...

To develop and evaluate the results of modified surgical technique for transplantation retinal pigment epithelium (RPE) differentiated from human induced pluripotent stem cells (iPSC-RPE) in form a cell suspension into subretinal space rabbits with previously RPE atrophy.

Purpose : to assess the level of catecholamines norepinephrine and dopamine in rat retina with experimental retinopathy prematurity (EROP) at a time corresponding peak neovascularization. Material methods . The study was performed on 41 infant Wistar rats (82 eyes). were divided into 2 groups: group (with EROP, n = 21) control (n 20). In order reproduce newborn placed for 14 days incubator together their mother. Every 12 hours, oxygen concentration ranged from 60 15 %. consisted pups who...

In this work, the results of a comprehensive laboratory examination 37 children with retinoblastoma were described. The presence Igm-, IgA, - IgG- antibodies to herpes simplex virus types 1 and 2, cytomegalovirus (СMV), epstein-Barr (eBV), human (HHV) type 6, Toxoplasma gondii, mycoplasma hominis ureaplasma urealyticum in serum was tested using ELISA. polymerase chain reaction DNA these pathogens detected blood plasma 18 patients tumor biopsy specimens from 10 eyes. showed that RB...

The course of a chronic HCV infection in 50% cases is followed by affection the brain. Its most frequent manifestations are various cognitive and psychogenic neurological disorders. It considered they based on activation infected microglial cells related to this exitotoxic injury neurons. According data literature similar changes microglia white matter play an important role pathogenesis HIV-associated subcortical dementia. Despite active studying infection, structural tissue reactions these...

Choroidal melanoma is a primary malignant intraocular tumor with unfavorable vital prognosis. Factors predisposing to invasion of choroidal into the optic nerve include its juxtapapillary localization, large size, diffuse growth, presence necrosis in tumor, increased pressure and epithelioid cell type tumor. The authors describe clinical case 31-year-old patient diagnosis an neoplasm. Peripapillary edema indistinct disc margins were found by ophthalmoscopy. There was slightly protruding...

Aim. Analysis of the results surgical treatment in patients with epibulbar malformations. Patients and Methods. The study included 126 a preliminary diagnosis “epibulbar neoplasm”, who received from January 2013 to December 2017. Male were 57.9 % (n = 73), female — 42.1 53). age range was 6 months 82 years (13.0 ± 11.4). All underwent complex ophthalmological examination histological verification obtained material. In case deficiency own tissues, when conjunctival defect closed, plastic made...

Background : The central nervous system damage is one of the most common extra hepatic manifestations chronic hepatitis C viral (HCV) infection, with prevalence up to 50% infected cases. Previous studies have identified main clinical, pathogenetic and neurometabolic features this pathology, which make it possible suggest its definite nosological independence. However, morphological pattern brain lesions in HCV infection remains virtually unexplored, significantly limiting possibility...

Conjunctival lymphomas are predominantly extranodal B-cell non-Hodgkin’s (NHL), most of them MALT-lymphomas originating from the mucosa-associated lymphoid tissue. Manifestations conjunctival NHL very diverse , and often imitate appearance other ocular diseases which makes their clinical diagnosis difficult significantly lengthens time first visit to ophthalmologist until is verified . The article presents case histories two young patients who were treated for a long at place residence as...

Purpose . To investigate the effect of resveratrol antioxidant on neurotrophic and structural changes retina/choroid tissue complex in experimental ischemia/reperfusion (I/R) injury retina induced by endothelin-1 (ET-1) injection rats. Material methods 60 male Wistar albino rats were divided into 3 groups. 50 underwent I/R (Group 1 [n = 20]; Group 2 30]) while 10 animals served as controls. Retinal was subconjunctival 0.2 mL 4 x -6 М ET-1. The received no resveratrol; those 20 mg/kg per os...

Disorders of the central nervous system observed in patients with chronic HCV infection seem to be associated excitotoxic lesion neurons caused by infected microglial cells. Despite high interest this problem, morphological changes microglia remain uninvestigated. The paper presents results morphologic study reactions white matter brain 40 who died HCV-infection. found structural and quantitative different parts brain, which is activation these cells HCV.

The present article describes a clinical case of ischemic cerebral infarction in а female patient with chronic HCV-infection. Although the prevalence this pathology does not seem to be very high comparison that general population, it remains life-threatening and must well studied as one possible neurologic complications HCV infection concordant mixed cryoglobulinemia, most prevalent anhepatic manifestation. However, etiology peculiarities visceral cryoglobulinemia manifestations need further...

Страница 8 РАК СЛЕЗНОЙ ЖЕЛЕЗЫ: ЭФФЕКТИВНОСТЬ КОМБИНИРОВАННОГО ЛЕЧЕНИЯ И ВИТАЛЬНЫЙ ПРОГНОЗ Саакян С.В., Амирян А

Background . Brain lesion is one of the most common extrahepatic manifestations chronic HCV infection. To date, its main clinical and neurometabolic features have been established. However, morphological picture HCV-associated cerebral changes peculiarities viral molecular markers expression in brain matter remain poorly understood. This significantly limits possibilities pathological diagnosis this disease. Aims study during infection to determine immunohistochemical (IHC) NS3 antigen...

Purpose. Retrospective analysis of clinical, instrumental, cytological and pathological features intraocular medulloepithelioma based on our own experience in the period from 2005 to 2018. Patients Methods. For a specified time department ocular oncology radiology Moscow Helmholtz Research Institute Eye Diseases we examined 9 patients aged 1 44 years (5 men 4 women), with confirmed histological diagnosis (medulloblastoma). The average age assessing vital status was 15.8 ± 13.5 years, at...

Background . Hepatic encephalopathy is an actual problem of modern medicine. However, its pathogenesis and histological picture are currently insufficiently studied. Less known about the impact nature primary liver disease on hepatic encephalopathy. This determines relevance further morphological studies brain in late stages cirrhosis various etiologies. The aim To establish compare changes alcoholic viral (hepatitis C virus (HCV)) cirrhosis. Materials methods study 40 deceased outcome...