A5033102209- Thyroid Cancer Diagnosis and Treatment
- Peripheral Artery Disease Management
- Lymphoma Diagnosis and Treatment
- Cardiac Imaging and Diagnostics
- Diabetic Foot Ulcer Assessment and Management
- Venous Thromboembolism Diagnosis and Management
- Cerebrovascular and Carotid Artery Diseases
- Radiation Dose and Imaging
- Body Composition Measurement Techniques
- Nutrition and Health in Aging
- Thyroid and Parathyroid Surgery
- Cardiac tumors and thrombi
- Child Nutrition and Feeding Issues
- Diet and metabolism studies
- Gastrointestinal motility and disorders
- Childhood Cancer Survivors' Quality of Life
- Gastroesophageal reflux and treatments
- Head and Neck Anomalies
- Inflammatory Biomarkers in Disease Prognosis
- Salivary Gland Tumors Diagnosis and Treatment
- CNS Lymphoma Diagnosis and Treatment
- Infant Health and Development
- Radiology practices and education
- Hip and Femur Fractures
- Clinical Nutrition and Gastroenterology
Nationwide Children's Hospital
2016-2025
University of Toledo Medical Center
2021
The Ohio State University
2013-2021
The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute
2021
Background: Physiologic iodide-uptake, mediated by the sodium/iodide symporter (NIS), in salivary gland confers its susceptibility to radioactive iodine–induced damage following 131I treatment of thyroid cancer. Subsequent quality life for cancer survivors can be decreased due recurrent sialoadenitis and persistent xerostomia. NIS expression at three principal duct components various pathological conditions was examined better our understanding modulation gland. Methods: evaluated...
Background Perfusion deficits contribute to symptom severity, morbidity, and death in peripheral artery disease (PAD); however, no standard method for quantifying absolute measures of skeletal muscle perfusion exists. This study sought preclinically test clinically translate a positron emission tomography (PET) imaging approach using an atherosclerosis‐targeted radionuclide, fluorine‐18‐sodium fluoride ( 18 F‐NaF), quantify PAD. Methods Results Eight Yorkshire pigs underwent unilateral...
Hodgkin lymphoma (HL) is a highly curable form of cancer, and current treatment regimens are focused on improving efficacy while decreasing the risk late effects treatment. The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for pediatric HL provide recommendations workup, diagnostic evaluation, classic HL, including principles pathology, imaging, staging, systemic therapy, radiation therapy. This portion focuses management upfront relapsed/refractory settings.
Objective: To investigate the feasibility of serial radiotracer-based imaging as a noninvasive approach for quantifying volumetric changes in microvascular perfusion within angiosomes foot following lower extremity revascularization setting critical limb ischemia (CLI). Approach: A CLI patient with nonhealing ulcer underwent single-photon emission computed tomography (SPECT)/computed (CT) feet before and after balloon angioplasty superficial femoral artery (SFA) popliteal artery. SPECT/CT...
Abstract Background Positron emission tomography (PET)/computed (CT) imaging with fluorine-18 ( 18 F)-sodium fluoride (NaF) provides assessment of active vascular microcalcification, but its utility for evaluating diabetes mellitus (DM)- and chronic kidney disease (CKD)-induced atherosclerosis in peripheral arterial (PAD) has not been comprehensively evaluated. This study sought to use F-NaF PET/CT quantify compare microcalcification on an artery-by-artery basis healthy subjects, PAD...
Pediatric patients with suspected gastroparesis often undergo antroduodenal manometry (ADM) and gastric emptying scintigraphy (GES) for diagnostic purposes. However, it is unknown if delayed (DGE) correlates manometric findings. This study evaluates whether ADM parameters differ between normal abnormal GES in pediatric patients. Data from undergoing at Nationwide Children's Hospital 2011-2020 were retrospectively reviewed. Manometry including motility index (Ln [sum of amplitudes × number...
Measurements of gastric emptying (GE) by scintigraphy in the pediatric population are based on adult standards. Due to radiation exposure, cannot be performed healthy children establish norms GE population. Stable isotope breath tests (GEBTs) pose no such health risk children. This study sought determine feasibility a GEBT and investigate whether may differ age, gender, or body mass index (BMI).Fifty 6 18 years underwent 13 C-Spirulina platensis GEBT. Breath samples were obtained at...
Objective: Peripheral artery disease (PAD) is associated with increased risk of nonhealing ulcers, amputation, and mortality due to occlusive atherosclerotic plaques. Computed tomography (CT) imaging detects vascular calcification in PAD; however, quantitative vessel-by-vessel analysis calcium burden the feet PAD patients has not been assessed. This study sought perform vessel-specific examine patient-level determinants foot patients. Approach: (n = 41) were prospectively enrolled underwent...
Abstract A 65-year-old man with an occluded popliteal artery aneurysm and calf claudication underwent PET/CT imaging 18 F-NaF to assess the status of active microcalcification in site additional lower extremity arteries. CT revealed macrocalcification that colocalized elevated retention on PET images. detected distal arterial sites focal uptake did not coincide CT-detectable macrocalcification. This report highlights a case occlusive peripheral using PET/CT. may provide molecular insight...
Positron emission tomography (PET)/computed (CT) imaging can detect changes in arterial inflammation, but has not been used to evaluate chemotherapy-induced venous inflammation or assess risk for thromboembolism (VTE) pediatric oncology. Therefore, the purpose of this study was prognostic value fluorine-18-fluorodeoxyglucose PET/CT predicting VTE occurrence 12 months after lymphoma diagnosis pediatric, adolescent, and young adult patients.Pediatric, patients with diagnoses (n=71) who...
Abstract BACKGROUND Somatostatin type-2A receptors (SST2A) regulate cell growth through complex downstream modulation of proliferation and apoptosis signaling, thereby representing a potential therapeutic target. Lutetium (177Lu-DOTATATE), radionuclide therapy which binds SST2A delivers local radiation via beta particle emission, gained FDA approval for gastroenteropancreatic neuroendocrine tumors, disease characterized by expression. Potential expansion Lutathera into pediatric...
Abstract A 15-year-old girl with a history of complex congenital heart disease and prior pulmonary valve replacement presented suspected endocarditis. PET/CT imaging 18 F-FDG was performed to evaluate the potential presence intracardiac vegetations after previously inconclusive findings from CT angiography, transthoracic echocardiography, transesophageal echocardiography. detected heterogeneous, asymmetric, increased uptake in region prosthesis, typical for infection, confirmed diagnosis...
Introduction: Increasing prevalence of arterial calcium in the lower extremities patients with peripheral disease (PAD) is associated worsening clinical outcomes. Calcium burden can be detected using standard imaging methods. However, quantitative evaluation specific arteries leg PAD uncommon setting, and association between quantified levels vessel-specific functional capacity remains understudied. We hypothesized that x-ray computed tomography (CT) could quantify mass superficial femoral...
Introduction: Lymphoma treatment with chemotherapy, alone or in combination radiation therapy, can have off-target effects that lead to vascular toxicity, which has recently gained attention the field of cardio-oncology. Positron emission tomography (PET)/computed (CT) imaging fluorine-18 ( 18 F)-fluorodeoxyglucose (FDG) is standard care for monitoring lymphoma responses and a widely accepted tool assessing inflammation. We hypothesized F-FDG PET/CT could detect quantify chemotherapy-induced...