A5038345311- Antioxidant Activity and Oxidative Stress
- Cancer, Lipids, and Metabolism
- Lipoproteins and Cardiovascular Health
- Emergency and Acute Care Studies
- Free Radicals and Antioxidants
- Eicosanoids and Hypertension Pharmacology
- Global Health Care Issues
- Heart Failure Treatment and Management
- Adipose Tissue and Metabolism
- Trauma and Emergency Care Studies
- Biochemical Acid Research Studies
- Potassium and Related Disorders
- Probiotics and Fermented Foods
- Healthcare Policy and Management
- Blood Pressure and Hypertension Studies
- Clinical Laboratory Practices and Quality Control
- Simulation-Based Education in Healthcare
- Cholesterol and Lipid Metabolism
- Enzyme Production and Characterization
- Retinoids in leukemia and cellular processes
- Nursing Roles and Practices
- Paraoxonase enzyme and polymorphisms
- Peroxisome Proliferator-Activated Receptors
- Protein Hydrolysis and Bioactive Peptides
- Magnesium in Health and Disease
American College of Emergency Physicians
2023
University of California, Los Angeles
1995-2007
Norwich Research Park
2001
Stobhill Hospital
1996
University of Michigan
1995
Our group has previously demonstrated that oxidized phospholipids in mildly LDL (MM-LDL) produced by oxidation with lipoxygenase, iron, or cocultures of artery wall cells increase monocyte-endothelial interactions and this sequence events is blocked HDL. To obtain further insight into the mechanism which HDL abolishes activity MM-LDL we investigated effect HDL-associated ester hydrolase paraoxonase (PON). Treatment purified PON significantly reduced ability to induce interactions....
Mildly oxidized low density lipoprotein (MM-LDL) produced by oxidative enzymes or cocultures of human artery wall cells induces endothelial to produce monocyte chemotactic protein-1 and bind monocytes. HDL prevents the formation MM-LDL cells. Using albumin treatment HPLC we have isolated partially characterized bioactive phospholipids in MM-LDL. Platelet activating factor-acetylhydrolase (PAF-AH), a serine esterase, hydrolyzes short chain acyl groups esterified sn-2 position such as PAF...
To determine the safety of spironolactone prescribing in setting UK National Health Service.Population based longitudinal analysis using a record linkage database.Tayside, Scotland. Population All patients who received one or more dispensed prescriptions for between 1994 and 2007.Rates spironolactone, hospital admissions hyperkalaemia, hyperkalaemia renal function without admission, before after publication results from Randomised Aldactone Evaluation Study (RALES).Prescriptions measurements...
An abstract is not available for this content so a preview has been provided. As you have access to content, full PDF via the ‘Save PDF’ action button.
Oxidized 1-palmitoyl-2-arachidonyl-sn-3-glycero-phosphorylcholine (Ox-PAPC) and its component phospholipid, 1-palmitoyl-2-(5,6 epoxyisoprostanoyl)-sn-glycero-3-phosphocholine (PEIPC), which are present in atherosclerotic lesions, activate endothelial cells (EC) to induce a complex inflammatory response. Previously, we demonstrated induction of genes regulating chemotaxis, sterol biosynthesis, the unfolded protein response, redox homeostasis by Ox-PAPC human aortic EC (HAEC). Activation c-Src...
Cardiovascular disease, caused mainly by atherosclerosis, kills more people in the United States than cancer, pulmonary and accidents combined. Atherosclerosis is build-up of cholesterol, lipids, concomitant inflammation leading to progressive narrowing vessel walls. LDL-derived oxidized phospholipids, such as 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine (Ox-PAPC), cause arterial wall promote atherosclerosis. D-4F an 18-amino acid peptide with physiochemical similarities one...
<h3></h3> Cardiovascular disease and stroke are the two leading causes of death in United States. Atherosclerosis, being central cause cardiovascular stroke, is process by which macrophages accumulate oxidized lipids, cholesterol, other fatty substances under endothelium blood vessels. While clinical consequences atherosclerosis clear, complex biochemical pathways that it not well understood. The oxidation low-density lipoproteins (LDL) a key step build up atherosclerotic plaques. Oxidized...
Prasad, N; Peebles, L; Anderson, J; MacCleod, C; Watson, A D; MacDonald, T M Author Information