A5080017667- Fungal Infections and Studies
- Antifungal resistance and susceptibility
- Plant-Microbe Interactions and Immunity
- Plant Pathogens and Fungal Diseases
- Yeasts and Rust Fungi Studies
- Nail Diseases and Treatments
- Plant Disease Resistance and Genetics
- Polar Research and Ecology
- Parasitic Infections and Diagnostics
- Cytomegalovirus and herpesvirus research
- Fungal and yeast genetics research
Universidade Federal de São Paulo
2016-2021
Paracoccidioides brasiliensis and P. lutzii, thermally dimorphic fungi, are the causative agents of paracoccidioidomycosis (PCM). infection occurs when conidia or mycelium fragments inhaled by host, which causes cells to transition yeast form. The development disease requires inside host alveoli differentiate into in a temperature-dependent manner. We describe presence two-component signal transduction system brasiliensis, we investigated expression analysis hypothetical protein gene...
The fungi Paracoccidioides brasiliensis and lutzii are the causative agents of paracoccidioidomycosis (PCM), a systemic mycosis endemic to Latin America. This fungus is considered facultative intracellular pathogen that able survive replicate inside macrophages. survival during infection depends on its adaptability various conditions, such as nitrosative/oxidative stress produced by host immune cells, particularly alveolar Currently, there little knowledge about spp. signaling pathways...
Paracoccidioides brasiliensis is the agent of paracoccidioidomycosis (PCM), a cause disease in healthy and immunocompromised persons Latin America. The infection begins after inhalation fungal propagules their thermo-dimorphic shift to yeast form. development depends on factors associated with host immune response infectious agent's characteristics, especially virulence. oxidative stress an important virulence attribute several fungi. In this study, we assessed enzymatic repertoire responses...
Paracoccidioidomycosis (PCM) is the most prevalent deep mycosis in Latin America and caused by fungi from Paracoccidioides genus. Virulence factors are important fungal characteristics that support development of disease. Aspartyl proteases (Saps) virulence many human pathogens play an role host invasion process. We report here immunization with recombinant Sap brasiliensis (rPbSap) imparted a protective effect experimental PCM model. The rPbSap-immunized mice had decreased loads, their lung...
Dimorphic fungi of the Paracoccidioides genus are causative agents paracoccidioidomycosis (PCM), an endemic disease in Latin America with a high incidence Brazil. This pathogen presents as infective mycelium at 25 °C soil, reverting to its pathogenic form when inhaled by mammalian host (37 °C). Among these dimorphic fungal species, dimorphism regulating histidine kinase (Drk1) plays essential role morphological transition. These kinases present bacteria and but absent cells important...
Differential modulation of S-nitrosoproteome Paracoccidioides brasiliensis by Nitric Oxide: change in Snitrosylation levels and fungal redox statusParacoccidioides P. lutzii are the causative agents paracoccidioidomycosis (PCM), a systemic mycosis endemic Latin America.These fungi considered facultative intracellular pathogens, able to survive replicate inside macrophages.After infection, survival depends on its adaptability host conditions, such as nitrosative stress caused nitric oxide...
Ras-MAPK pathway participates of the nitrosative stress response in pathogenic fungus Paracoccidioides brasiliensisParacoccidioides brasiliensis is a temperature-dependent dimorphic that cause paracoccidioidomycosis (PCM).The capacity to evade innate immune host due its ability respond and survive caused by cells system.However, regulation signal transduction pathways associated are poorly understood.Ras GTPases (Ras1 Ras2) well known regulate antagonistically or cooperatively various...
Regulation of DNA repair machinery in Paracoccidioides brasiliensis during stress induction P. fungus performs the pathogenic switch from mycelium to yeast at 37ºC, human body temperature and involves a series transcription changes, mainly virulence related genes oxidative responsive genes.Reactive oxygen species are well known threatening integrity capacity cope with imposed by immune cells host is essential infection disease progression.Homologous recombination (HR) non-homologous end...