Cut here to cure: Doxorubicin attached pH-sensitive mesoporous silica nanoparticles (MSN-hydrazone-Dox) shows potential in the chemotherapeutic treatment of liver cancer. Hydrolysis hydrazone bond acidic environment endosomes/lysosomes (see picture) releases Dox intracellularly from MSN nanochannels, resulting highly efficient apoptotic cell death. Detailed facts importance specialist readers are published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or...

Abstract The characterization of near‐infrared (NIR) mesoporous silica nanoparticles (MSN) suitable for in vivo optical imaging with high efficiency is presented. Trimethylammonium groups modified MSN (MSN‐TA) the average size 50–100 nm was synthesized incorporation TA into framework MSN. It further adsorbed indocyanine green (ICG) by electrostatic attraction to render MSN‐TA‐ICG as an efficient NIR contrast agent imaging. studies stability against pH indicated bonding stable over range from...

In this work we report the development of tri-functionalized mesoporous silica nanoparticles (MSNs) for use as theranostic compounds that orchestrate trio imaging, target and therapy in a single particle. The MSNs are functionalized sequence with (1) contrast agents enable traceable imaging particle targeting, (2) drug payloads therapeutic intervention and, (3) biomolecular ligands highly-targeted delivery. Traceable was accomplished by directly incorporating near-infrared (NIR) fluorescent...

Abstract We synthesized mesoporous silica nanoparticles (MSN) with different densities of surface positive charges. The charge was generated by incorporating trimethylammonium (TA) functional groups into the framework MSN (MSN–TA) via direct co‐condensation a TA‐silane and tetraethoxysilane (TEOS) in presence base as catalyst. These MSN–TA samples have well‐defined hexagonal structures an average particle diameter 100 nm, pore size 2.7 area about 1000 m 2 g −1 . Anionic drug molecules,...

Functionalization of mesoporous silica nanoparticles (MSNs) with Pd-porphyrins for cancer cell photodynamic therapy is reported. The composite platform, MSN–PdTPP, expands the role from their routine use as phosphorescence probes oxygen sensing/imaging (diagnostics) to that novel nano-photosensitizers phototherapy (therapeutics). utility MSN–PdTPP in phototherapeutic treatment MDA-MB-231 breast cells also evaluated, suggesting it a promising theranostic platform.

Recently, multidrug resistance (MDR) has become a major clinical chemotherapeutic burden that robustly diminishes the intracellular drug levels through various mechanisms. To overcome doxorubicin (Dox) in tumor cells, we designed hierarchical nanohybrid system possessing copper-substituted mesoporous silica nanoparticles (Cu-MSNs). Further, Dox was conjugated to copper metal Cu-MSNs framework pH-sensitive coordination link, which is acutely sensitive acidic environment (pH 5.0–6.0). In end,...

Abstract Despite their advantageous morphological attributes and attractive physicochemical properties, mesoporous silica nanoparticles (MSNs) are merely supported as carriers or vectors for a reason. Incorporating various metal species in the confined nanospaces of MSNs (M‐MSNs) significantly enriches architecture diverse functionalities, bringing exciting potentials to this burgeoning field research. These incorporated guest offer enormous benefits MSN hosts concerning reduction eventual...

Scope We investigated whether rutin, a flavonoid isolated from Toona sinensis Roem, has the ability to enhance insulin-dependent receptor kinase (IRK) activity and glucose transporter 4 (GLUT4) translocation in differentiated myotubes. also tested effects of rutin treatment insulin-resistant mice using an oral tolerance test (OGTT). Methods results Rutin potentiated insulin phosphorylation when IRK autophosphorylation was triggered by Co-treatment cells with attenuated S961-mediated...

The use of nanotechnology to overcome multidrug resistance (MDR) in cancer cells has been predominant. Herein, we report the conjugation copper(ii)-doxorubicin complexes on surfaces layered double hydroxide nanoparticles (LDHs) along with ascorbic acid intercalation gallery space demonstrate synergistic effects conquer MDR. pH-sensitive release doxorubicin (Dox) and sustained (AA) generate high amounts hydrogen peroxide intracellularly that concomitantly results conversion cytotoxic free...

Multidrug resistance (MDR) is the major clinical obstacle in management of cancer by chemotherapy. Overexpression ATP-dependent efflux transporter P-glycoprotein (PGP) a key factor contributing to multidrug cells. The purpose present study was use endosomal pH-sensitive MSN (mesoporous silica nanoparticles; MSN-Hydrazone-Dox) for controlled release doxorubicin (Dox) an attempt overcome PGP-mediated MDR. In vitro cell culture studies indicate that uptake MSN-Hydrazone-Dox human uterine...

Rohr frei zur Krebsbekämpfung: Mit Doxorubicin bestückte pH-empfindliche mesoporöse Siliciumdioxidnanopartikel (MSN-Hydrazon-Dox) eignen sich möglicherweise für die Chemotherapie von Leberkrebs. Nach der Hydrolyse pH-empfindlichen Hydrazon-Verbindung im sauren Milieu Endosomen/Lysosomen (siehe Bild) wird Dox aus den Nanokanälen MSNs ins Zellinnere freigesetzt, wo es hoch wirksam eine Apoptose induzieren kann.

We incorporated a near-infrared (NIR) fluorescent dye, indocyanine green (ICG), in amine-modified layered double hydroxide nanoparticles (LDHs) by electrostatic attractions to render LDHs–ICG as an efficient NIR contrast agent for vivo optical imaging. The further coating of chitosan on the external surfaces was achieved through cross-linking LDHs and different amounts using glutaraldehyde (GA) cross-linked agent. hybridization this organic–inorganic nanocomposite produced because adsorbed...

An efficient approach for the antimicrobial agent delivery specifically at acidic pH has been proposed. At outset, functionalized mesoporous nanoparticles (NPs) were examined to verify success of synthesis while considering structural properties by various characterizations. The NPs immobilized with silver-indole-3 acetic acid hydrazide (IAAH-Ag) complexes via a pH-sensitive hydrazone bond, which functioned as model drug. When transitional metal IBN-4-IAAH-Ag exposed (near 5.0), silver ions...

Hydrothermally stable and structrurally ordered mesoporous microporous aluminosilicates with different pore sizes have been synthesized to immobilize cytochrome c (cyt c): MAS-9 (pore size 90 Å), MCM-48-S (27 MCM-41-S (25 Y zeolites (7.4 Å). The amount of cyt adsorption could be increased by the introduction aluminum into framework pure silica materials. Among these mesoprous silicas (MPS), showed highest loading capacity due its large size. However, immobilized in undergo facile unfolding...

We designed a novel oral colon-specific drug delivery system (OCDDS) using modification of mesoporous silica nanoparticle (MSN) surfaces with pH-sensitive trimethylammonium (TA) groups through hydrazone bond. The TA can efficiently increase the loading amounts anionic drugs by strong electrostatic attraction. After administration, acidic pH gastric juice fully hydrolyze TA–hydrazone bonds and further eliminate positive charges from MSN surfaces. When hydrolyzed complexes were delivered to...

Intracellular hydrogen peroxide levels have the potential to be exploited in cancer therapy.

The role of nanoparticle charge in biodistribution is evaluated by modifying the external surface layered double hydroxides with various charges and a fluorescent dye (Cy5.5) doped to assess biodistribution.

Abstract Recently, layered double hydroxides (LDHs) have gathered vast interest due to overall positive charge, unique crystallinity, and biocompatibility for diverse applications. Despite the advantageous attributes, these hydrotalcites often result in several limitations concerning application requirements, such as aggregation, well poor chemical thermal stabilities, hindering their scale‐up progress practical utilization. In addressing issues, recent advancements fabrication of...