A5075060474- Carbohydrate Chemistry and Synthesis
- RNA Interference and Gene Delivery
- Lipid Membrane Structure and Behavior
- Glycosylation and Glycoproteins Research
- Supramolecular Self-Assembly in Materials
- Advanced biosensing and bioanalysis techniques
- Enzyme Catalysis and Immobilization
- Surfactants and Colloidal Systems
- Seaweed-derived Bioactive Compounds
- Synthetic Organic Chemistry Methods
- Environmental Chemistry and Analysis
- Virus-based gene therapy research
- Microbial Natural Products and Biosynthesis
- Analytical Chemistry and Chromatography
- Enzyme Production and Characterization
- RNA and protein synthesis mechanisms
- biodegradable polymer synthesis and properties
- Marine and coastal plant biology
- Chemical Synthesis and Analysis
- Chemical Synthesis and Reactions
- Bacteriophages and microbial interactions
- Nanoparticle-Based Drug Delivery
- Liquid Crystal Research Advancements
- Immunotherapy and Immune Responses
- Polydiacetylene-based materials and applications
Centre National de la Recherche Scientifique
2013-2025
Université de Rennes
2011-2025
École Nationale Supérieure de Chimie de Rennes
2015-2025
Institut des Sciences Chimiques de Rennes
2012-2023
Université Rennes 2
2018-2020
Lebanese American University
2018
Université de Bretagne Occidentale
2010-2016
Université Bretagne Loire
2016
Université Européenne de Bretagne
2008-2015
École Normale Supérieure - PSL
1998-2011
In vitro transcribed mRNA constitutes a versatile platform to encode antigens and evoke CD8 T-cell responses. Systemic delivery of packaged into cationic liposomes (lipoplexes) has proven particularly powerful in achieving effective antitumor immunity animal models. Yet, responses lipoplexes critically depend on the induction type I interferons (IFN), potent pro-inflammatory cytokines, which inflict dose-limiting toxicities. Here, we explored an advanced hybrid lipid polymer shell...
The term liquid crystal is often associated with fascinating compounds that exhibit unusual melting or solubilisation properties, however, it also represents a unique collection of mesophases exist between the solid state and amorphous liquid. As such, this matter can be accessed by wide variety materials from low molar mass to polymeric systems. In Feature Article we describe some recent studies concerning liquid-crystalline behaviour 'in-between' have discrete molecular structures, which...
A variety of authentic standards linear, branched and cyclic oligomers glycerol, with well-defined structures degrees polymerisation from 2 to 5, have been efficiently synthesised. Linear were obtained by means a convergent approach based on regioselective opening bis(epoxides) solketal; compounds synthesised using oxidative cleavage the corresponding anhydrohexitols as key step. 6-exo-trig halocyclisation reaction involving heteroatom-tethered unsaturated alcohols permitted an efficient...
Novel cationic liposomes, termed "archaeosomes", based on mixtures of neutral/cationic bilayer-forming lipids and archaeobacterial synthetic tetraether-type bipolar show efficient in vitro gene transfection properties represent a new approach for modulating the lipidic membrane fluidity complexes they form with DNA.
Abstract This microreview focuses on the development of diether‐type and tetraether‐type archaeal lipids as innovative materials for biotechnological applications, with special attention to synthetic analogues well recent natural lipid structures. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
This article describes the synthesis, properties and potential applications of new cationic surfactants based on natural glycine betaine vegetable oils as renewable raw materials. Convenient procedures were developed a multigram scale using environmentally friendly starting materials to provide betaine-derived esters amides. Some readily biodegradable formulations containing ester-type surfactant found exhibit remarkable emulsifying for road making they are now under industrial development...
We report for the first time preparation of mannosylated and histidylated lipopolyplexes (Man-LPD100) with uptake transfection selectivity dendritic cells (DCs). Man-LPD100 were prepared by addition liposomes (Man-Lip100) on preformed PEGylated polylysine/DNA polyplexes. Man-Lip100 comprised a cationic [O,O-dioleyl-N-(3N-(N-methylimidazolium iodide)propylene) phosphoramidate)] lipid, neutral [O,O-dioleyl-N-histamine Phosphoramidate] co-lipid β-D-mannopyranosyl-N-dodecylhexadecanamide...
Unsymmetrical bolaamphiphiles 1a−1d bearing a neutral glycosidic polar head and an electropositive ammonium group at opposite ends of polymethylene bridging spacer were efficiently synthesized. An additional alkoxy was introduced the anomeric site carbohydrate in order to yield anomerically defined compounds, allow modulation hydrophobic−hydrophilic balance (HLB), increase dissymmetry monomers. The self-assembling properties bolaphiles investigated both concentrated more diluted aqueous...
The in vitro stability of archaeosomes made from novel synthetic membrane-spanning tetraether lipids was evaluated conditions mimicking those oral route application terms bile salts, serum and low pH..
A synthetic route for the preparation of symmetrical and unsymmetrical archaeal tetraether-like analogues has been described. The syntheses are based upon elaboration hemimacrocyclic tetraether lipid cores from versatile building blocks followed by simultaneous or sequential introduction polar head groups. Functionalizations lipids with neutral lactose phosphatidylcholine heads cationic glycine betaine moieties were envisaged both to increase membrane stability exhibit interactions charged...
Abstract HepaRG progenitor cells are capable of differentiating into hepatocyte‐like that express a large set liver‐specific functions. These cells, however, only small amounts an important cytochrome P450, the CYP2E1, which limits their use for toxicological studies drugs metabolized by this pathway. Our aim was to establish efficient transfection protocol increase CYP2E1 expression in cells. Transfection protocols green fluorescent protein (GFP) reporter gene were evaluated using...