A5048366595- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- RNA Research and Splicing
- Molecular Biology Techniques and Applications
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Diabetes and associated disorders
- Cancer Mechanisms and Therapy
- Adipokines, Inflammation, and Metabolic Diseases
- Atherosclerosis and Cardiovascular Diseases
- Cystic Fibrosis Research Advances
- Acute Myeloid Leukemia Research
- Neonatal Respiratory Health Research
- Genetics and Neurodevelopmental Disorders
- Pancreatic function and diabetes
- RNA Interference and Gene Delivery
- Cancer-related Molecular Pathways
- FOXO transcription factor regulation
- Immunodeficiency and Autoimmune Disorders
- DNA Repair Mechanisms
- Angiogenesis and VEGF in Cancer
- Genetic Syndromes and Imprinting
- Glutathione Transferases and Polymorphisms
- Hearing, Cochlea, Tinnitus, Genetics
Tehran University of Medical Sciences
2014-2023
Islamic Azad University Bandar Abbas
2020
Shiraz University of Medical Sciences
2018
Fasa University of Medical Sciences
2018
Endocrinology Research Center
2011
Shariati Hospital
2010
University of Tehran
2009
There are rising concerns about how to teach psychosocial aspects of medicine students. The aim the study was use "cinemedicine" as a tool and technique in teaching medical students at Tehran University Medical Sciences (TUMS).This an educational with quantitative qualitative data analysis. Two hundred seventy participated this study. Nine sessions were held subjects using movies. Each session began initial explanation program objectives. After show, related points movie discussed analyzed...
Introduction: Epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy worldwide and despite an initial response to therapeutic agents, majority of patients have chemoresistant disease. There no treatment strategy with proven efficacy against EOC in this setting, overcoming therapy resistance key successful treatment. Methods: This study aimed investigate expression interleukin-6 (IL-6) IL-6 receptor (IL-6R) a panel cell lines. To achieve this, its were compared cells using...
Abstract Background Circular RNAs (circRNAs) have been implicated in the initiation and development of breast cancer as functional non-coding (ncRNA). The roles circRNAs competing endogenous (ceRNAs) to sponge microRNAs (miRNAs) also indicated. However, functions not totally elucidated. This study aimed explore clinical implications possible circ_0044234 carcinogenesis most problematic BC subtype, triple negative (TNBC), which are desperate need biomarkers targeted therapies. Methods...
Adiponectin gene polymorphisms are associated with obesity, metabolic syndrome and type 2 diabetes (T2D). The study evaluated possible associations of +45T/G -11391G/A adiponectin body mass index (BMI), waist circumferences (WC), blood pressure in diabetic non-diabetic Iranians.This cross-sectional involved two groups subjects: 243 patients 173 subjects recruited from Rafsanjan city the south-east Iran.No significant association was found between systolic or diastolic pressure. However, male...
Abstract Epithelial ovarian cancer (EOC) is the most lethal gynaecological malignancy worldwide. Development of chemoresistance and peritoneal dissemination EOC cells are major reasons for low survival rate. Targeting signal transduction pathways which promote therapy resistance metastatic key to successful treatment. Members ErbB family receptors over-expressed in play roles invasiveness. Despite this, single-targeted inhibitors have demonstrated limited activity chemoresistant EOC. In this...
Occupational exposure to benzene has been associated with leukemia, anemia, leukopenia, and thrombocytopenia. Genetic susceptibility toxicity in humans may be related variations metabolizing genes. The main objective of this study was ascertain whether polymorphism GSTP1, GSTM1, GSTT1 CYP2E1 genes might influence the adverse effects among employees a petrochemical plant. In cross-sectional study, 124 plant who had occupationally exposed one or more abnormal hematological parameter (cases)...
Nitric oxide (NO) is a major mediator in vascular biology, regulating blood pressure and regional flow. NO the enzymes required for its production may contribute to aetiology of pathologies. In diabetes, over-production might play role development diabetic nephropathy, while reduced be related retinopathy neuropathy, where VEGF (vascular endothelial growth factor) levels are increased counter regulatory manner. Among three nitric synthase (NOS) most attention has focussed on NOS (eNOS)...
Iran is located in the Asian esophageal cancer belt. It a high-risk region for squamous cell carcinoma (ESCC). The extent to which genetic components, especially variants within miRNAs or their binding sites, contribute risk of ESCC not yet fully understood. Herein, tests were done on an Iranian cohort evaluate association miRNA-related polymorphisms miR-423 (rs6505162) and peroxisomal biogenesis factor 6 (PEX6) (rs1129186 miR-149-5p-binding site) with risk.This study recruited 200 patients...
The transcription factor 7-like 2 gene (TCF7L2) rs7903146 T allele is constantly associated with Type diabetes in various populations and ethnic groups. Nevertheless, this has not been observed two studies involving Arab populations. aim of the present study was to investigate association between TCF7L2 an Iranian population. patients (N = 258) normal healthy control subjects 168) from same area, were examined. ARMS- PCR (Amplification Refractory Mutation System) technique, subsequently...
Long noncoding RNAs (lncRNAs) constitute a major class of the human transcriptome which play crucial roles in key biological processes both normal and malignant breast cells. Although aberrant expression lncRNAs has been well-documented cancer (BC), little is currently known about association between their levels tissue healthy women BC risk factors, especially reproductive or demographic characteristics that are among most well-known modifiers. This study was an attempt to investigate...
Poly (ADP-ribose) polymerase-1 (PARP-1) plays an important role in the repair of damaged DNA and has prognostic significance a variety human malignancies. However, little is known about its expression levels clinical implication patients with acute myeloid leukemia (AML).Quantitative reverse transcription-polymerase chain reaction was done to evaluate PARP-1 bone marrow 65 non-M3 AML 54 healthy counterparts. The correlation clinicopathological features also analyzed.Non-M3 have higher than...