A5033788817- interferon and immune responses
- Nanoplatforms for cancer theranostics
- Immune Response and Inflammation
- Inflammasome and immune disorders
- Nanoparticle-Based Drug Delivery
- HIV Research and Treatment
- Immune Cell Function and Interaction
- Antifungal resistance and susceptibility
- Microbial Inactivation Methods
- Lung Cancer Treatments and Mutations
- RNA regulation and disease
- Cancer-related molecular mechanisms research
- Viral Infections and Vectors
- RNA Interference and Gene Delivery
- Immunodeficiency and Autoimmune Disorders
- Mosquito-borne diseases and control
- Probiotics and Fermented Foods
- Advanced biosensing and bioanalysis techniques
- T-cell and Retrovirus Studies
Nanomed (Brazil)
2024-2025
Universidade Federal do Pará
2021-2024
Grupo Hospitalar Conceição
2021
Care-related infections (CRIs) have a negative impact on the morbidity and mortality of patients in intensive care. Among them, fungal (e.g. Candida spp. Aspergillus spp.) high critically ill patients, particularly those with acute respiratory distress syndrome (ARDS) immunosuppression. Coronavirus disease 2019 (COVID-19) causes severe changes deregulation immune system. Here, we describe case infection an care unit (ICU) patient COVID-19 caused by Saccharomyces cerevisiae, yeast widely used...
Abstract Background The HIV-1 epidemic is still considered a global public health problem, but great advances have been made in fighting it by antiretroviral therapy (ART). ART has considerable impact on viral replication and host immunity. production of type I interferon (IFN) key to the innate immune response infections. STING cGAS proteins proven roles antiviral cascade. present study aimed evaluate immunity, which was represented gene expression plasma IFN-α level. Methods This cohort...
Autoimmune diseases can develop during HIV-1 infection, mainly related to the individual's immune competence. The study investigated association of TREX1 531C/T polymorphism and antinuclear antibodies (ANA) in infection time antiretroviral therapy (ART) used. Cross-sectional longitudinal assessments were carried out 150 individuals, divided into three groups: ART-naïve, 5 years 10 on ART; ART-naïve individuals evaluated for 2 after initiation treatment. individuals' blood samples submitted...
TREX1 acts in the initial prevention of an autoimmune response, but it may contribute to permissiveness retrovirus infections. This study investigated association between levels gene expression with polymorphisms rs3135941 (T/C) and rs3135945 (G/A), presence antinuclear antibodies (ANA) antiretroviral therapy (ART)-naïve individuals after 1 year treatment. Blood samples from 119 HIV-1 were subjected genotyping quantification viral load by qPCR. The concentration IFN-α number CD4+/CD8+ T...
O gene TREX-1 é a principal exonuclease de DNA, com especificidade para redução ssDNA no citosol, representando um regulador negativo da imunidade inata em resposta à presença DNA viral durante infecção pelo HIV-1. A ausência ativação decorrente mutações responsável acúmulo anormal citosólico e, consequentemente, estímulo pró-inflamatória intensa e crônica, virtude do aumento produção INF-α. Essa deficiência pode estar correlacionada polimorfismos, os quais podem influenciar na perda...
Abstract Background: The HIV-1 epidemic is still considered a global public health problem, but great advances have been made in fighting it by antiretroviral therapy (ART). ART has considerable impact on viral replication and host immunity. production of type I interferon (IFN) key to the innate immune response infections. STING cGAS proteins proven roles antiviral cascade. present study aimed evaluate immunity, which was represented gene expression plasma IFN-α level. Methods: This cohort...