A5032470864- Venous Thromboembolism Diagnosis and Management
- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Drug Transport and Resistance Mechanisms
- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatic and Hepatic Oncology Research
- Complement system in diseases
- Systemic Sclerosis and Related Diseases
- Advancements in Transdermal Drug Delivery
- Neurogenetic and Muscular Disorders Research
- Cancer Research and Treatments
- Parvovirus B19 Infection Studies
- Vascular Malformations and Hemangiomas
- Hereditary Neurological Disorders
- Viral-associated cancers and disorders
- Gastrointestinal disorders and treatments
- Glycogen Storage Diseases and Myoclonus
- Eosinophilic Disorders and Syndromes
- Dysphagia Assessment and Management
- Vascular Anomalies and Treatments
- Neurological diseases and metabolism
- Platelet Disorders and Treatments
- Central Venous Catheters and Hemodialysis
- Cholesterol and Lipid Metabolism
- Cerebrospinal fluid and hydrocephalus
Kyushu University
2018-2020
Kyoto Research Park
2018-2020
Maruho (Japan)
2018-2020
National Hospital Organization Kochi National Hospital
2006-2019
Columbus Oncology and Hematology Associates
2018
University of Florida
2018
Committee on Publication Ethics
2007
Kōchi University
2006
Kochi Medical School Hospital
1990-2002
National Center of Neurology and Psychiatry
1996
The identification of drug transporters expressed in human skin and interindividual differences gene expression is important for understanding the role skin. In present study, we evaluated ATP-binding cassette (ABC) solute carrier (SLC) using tissues. samples, ABCC3 was at highest levels, followed by SLCO3A1, SLC22A3, SLC16A7, ABCA2, ABCC1, SLCO2B1. Among quantitated transporters, accounted 20.0% total mean transporter mRNA content. showed large variability (9.5-fold). None single nucleotide...
Abstract This study aimed to characterize the population pharmacokinetics and exposure‐response relationship of propranolol (Hemangiol ® Syrup for Pediatric) in infants with infantile hemangioma. Using nonlinear mixed‐effects modeling 63 pooled sets plasma concentration‐time data from 32 Japanese patients aged 35‐150 days, we described disposition adequately by a 1‐compartment model first‐order absorption. The estimated mean apparent clearance central volume distribution were 9.34 L/h 146 L,...
A 3-year-old boy with Q fever received several kinds of antibiotics including minocycline, but spiking and positive PCR Coxiella burnetii continued for months. He became asymptomatic his abnormal laboratory data normalized after the administration gamma interferon three times a week. was admitted to our hospital because prolonged fever, abdominal pain thrombocytopenia. born healthy parents had been well until onset although younger sister died septicemia Streptococcus oraris at 3 months age,...
Objective: Patients with severe motor and intellectual disabilities (SMID) often develop complications, including paralysis of the extremities due to abnormal muscular tonicity. Furthermore, incidence sudden death, which may be caused by pulmonary thromboembolism (PTE), is approximately 4.2%. Deep vein thrombosis (DVT) attracting attention as an embolic source. In this study, DVT was confirmed in SMID patients lower extremity venous ultrasound. The oral anticoagulant, warfarin, novel...
In this article, we first report a case of recurrent paroxysmal cold hemoglobinuria with serologic confirmation. On 2 occasions, the Donath-Landsteiner (DL) antibodies belonged to an IgM subclass and showed neither anti-P nor anti-I specificity. Furthermore, it is very interesting that temperature thresholds DL were different on each occasion. Although acute considered be self-limited transient, should careful its possible recurrence. tests must repeated after complete recovery from episode,...
Summary: Sudden death in patients with severe motor and intellectual disabilities (SMID) is sometimes caused part by pulmonary thromboembolism (PTE), deep venous thrombosis (DVT) has drawn attention as a possible embolic source. Warfarin, which conventional therapeutic agent, not easy to control appropriately, daily management can be especially difficult SMID patients. On the other hand, edoxaban tosilate hydrate, been newly approved for insurance coverage treatment of DVT, listed Guidelines...
Abstract A case report is presented of a 15‐year‐old girl with reflex sympathetic dystrophy (RSD). She was referred to hospital because left upper limb pain. Her cold, edematous and blue limited active range movement. The serum concentration noradrenaline lower on the painful side than healthy side, neurotropin, which has an antinociceptive effect hyperalgesia, clearly effective. Early diagnosis management essential in treatment RSD administration neurotropin useful non‐invasive without...
AbstractA 21-year-old man with granular lymphocyte-proliferative disorders (GLPD) associated chronic active Epstein-Barr virus (EBV) infection is described. Chromosomal analyses revealed several clonal abnormalities and two of them were mainly repetitious. High copy numbers monoclonal EBV genome also detected in the proliferative large lymphocytes (LGLs), indicating expansion EBV-infected LGLs. The patient had an indolent course for years, there was no evidence infiltrations his bone marrow...
Intramural hematoma of the duodenum is rare and usually occurs following a blunt abdominal trauma. A case traumatic intramural in child reported. The patient was 6-year-old male with chief complaints bilious vomiting pain after Preoperative diagnosis considered to be duodenal obstruction operation performed on 2nd day onset. found involving from 3rd portion. evacuated. Although still had symptoms obstruction, he began allow oral intake 23rd p.o.d. discharged 45th uneventfully. Recently...