A5011195159- Genetic and phenotypic traits in livestock
- Genetic Mapping and Diversity in Plants and Animals
- Ultrasonics and Acoustic Wave Propagation
- Genetics and Plant Breeding
- Cancer-related molecular mechanisms research
- Animal Genetics and Reproduction
- Geophysical Methods and Applications
- Seismic Waves and Analysis
- Advanced Fiber Optic Sensors
- Animal Nutrition and Physiology
- Genetic Associations and Epidemiology
- Animal Behavior and Welfare Studies
- Milk Quality and Mastitis in Dairy Cows
- Genetic diversity and population structure
- Wheat and Barley Genetics and Pathology
- Gene expression and cancer classification
- Non-Destructive Testing Techniques
- Reproductive Physiology in Livestock
- Molecular Biology Techniques and Applications
- Effects of Environmental Stressors on Livestock
- Structural Health Monitoring Techniques
- RNA Research and Splicing
- Genomic variations and chromosomal abnormalities
- Ruminant Nutrition and Digestive Physiology
- Genomics and Phylogenetic Studies
University of Liège
2016-2025
CEA LIST
2015-2024
Université Paris-Saclay
2021-2024
Commissariat à l'Énergie Atomique et aux Énergies Alternatives
2015-2024
Fund for Scientific Research
1999-2023
Integra (United States)
2016-2023
Ghent University
2016-2022
Genomics (United Kingdom)
2010-2021
Maison de la Simulation
2019
Institut d'électronique de microélectronique et de nanotechnologie
2015-2016
Size of the reference population and reliability phenotypes are crucial factors influencing genomic predictions. It is therefore useful to combine closely related populations. Increased accuracies predictions depend on number individuals added population, their phenotypes, relatedness populations that combined. This paper assesses increase in achieved when combining four Holstein 4000 bulls each, from European breeding organizations, i.e. UNCEIA (France), VikingGenetics (Denmark, Sweden,...
Abstract Faithful reconstruction of haplotypes from diploid marker data (phasing) is important for many kinds genetic analyses, including mapping trait loci, prediction genomic breeding values, and identification signatures selection. In human genetics, phasing most often exploits population information (linkage disequilibrium), while in animal genetics the primary source familial (Mendelian segregation linkage). We herein develop evaluate a method that simultaneously both sources...
In dairy cattle, the widespread use of artificial insemination has resulted in increased selection intensity, which led to spectacular increase productivity. However, cow fertility concomitantly severely declined. It is generally assumed that this reduction primarily due negative energy balance high-producing cows at peak lactation. We herein describe fine-mapping a major QTL Nordic Red and identify 660-kb deletion encompassing four genes as causative variant. show recessive embryonically...
We use >250,000 cross-over events identified in >10,000 bovine sperm cells to perform an extensive characterization of meiotic recombination male cattle. map Quantitative Trait Loci (QTL) influencing genome-wide rate, hotspot usage, and locus-specific rate. fine-map three QTL present strong evidence that genetic variants REC8 RNF212 influence while PRDM9 usage.
Abstract Inbreeding results from the mating of related individuals and may be associated with reduced fitness because it brings together deleterious variants in one individual. In general, inbreeding is estimated respect to an arbitrary base population consisting ancestors that are assumed unrelated. We herein propose a model‐based approach estimate characterize individual at both global local genomic scales by assuming genome mosaic homozygous‐by‐descent (HBD) non‐HBD segments. The HBD...
We herein report the result of a large-scale, next generation sequencing (NGS)-based screen for embryonic lethal (EL) mutations in Belgian beef and New Zealand dairy cattle. estimated by simulation that cattle might carry, on average, ∼0.5 recessive EL mutations. mined exome sequence data from >600 animals, identified 1377 stop-gain, 3139 frame-shift, 1341 splice-site, 22,939 disruptive missense, 62,399 benign 92,163 synonymous variants. show have comparable load loss-of-function (LoF)...
Abstract Identifying homozygous‐by‐descent (HBD) regions in individual genomes is highly valuable to infer the recent history of populations and provide insights into trait architecture. Here, we present RZooRoH R ‐package that implements an efficient accurate model‐based approach identify HBD segments. The underlying hidden Markov model partitions genome‐wide autozygosity different age‐related classes while accounting for genotyping errors genetic map information. package user‐friendly...
Abstract The estimation of the inbreeding coefficient ( F ) is essential for study depression (ID) or management populations under conservation. Several methods have been proposed to estimate realized using genetic markers, but it remains unclear which one should be used. Here we used whole-genome sequence data 245 individuals from a Holstein cattle pedigree empirically evaluate estimators best capture homozygosity at variants causing ID, such as rare deleterious alleles loci presenting...
A QTL detection experiment was performed in French dairy cattle to search for related male fertility. Ten families, involving a total of 515 bulls, were phenotyped ejaculated volume and sperm concentration, number spermatozoa, motility, velocity, percentage motile spermatozoa after thawing abnormal spermatozoa. set 148 microsatellite markers used realize genome scan. First, genetic parameters estimated all traits. Semen production traits found have moderate heritabilities (from 0.15 0.30)...
Genomic selection is implemented in French Holstein, Montbéliarde, and Normande breeds (70%, 16% 12% of dairy cows). A characteristic the model for genomic evaluation use haplotypes instead single-nucleotide polymorphisms (SNPs), so as to maximise linkage disequilibrium between markers quantitative trait loci (QTLs). For each trait, a QTL-BLUP (i.e. best linear unbiased prediction including QTL random effects) includes 300–700 trait-dependent chromosomal regions selected either by analysis...
We herein study genetic recombination in three cattle populations from France, New Zealand, and the Netherlands. identify 2,395,177 crossover (CO) events 94,516 male gametes, 579,996 CO 25,332 female gametes. The average number of COs was found to be larger males (23.3) than females (21.4). heritability global rate (GRR) estimated at 0.13 0.08 females, with a correlation 0.66 indicating that shared variants are influencing GRR both sexes. A genome-wide association identified seven...
The inbreeding coefficient (
Clinical mastitis (CM) is an inflammatory disease occurring in the mammary glands of lactating cows. CM under genetic control, and a prominent resistance QTL located on chromosome 6 was reported various dairy cattle breeds. Nevertheless, biological mechanism underpinning this has been lacking. Herein, we mapped, fine-mapped, discovered putative causal variant underlying Dutch population. We identified ~12 kb multi-allelic copy number (CNV), that perfect linkage disequilibrium with lead SNP,...
We herein describe the positional identification of a 2-bp deletion in open reading frame MRC2 receptor causing recessive Crooked Tail Syndrome cattle. The resulting frame-shift reveals premature stop codon that causes nonsense-mediated decay mutant messenger RNA, and virtual absence functional Endo180 protein affected animals. Cases exhibit skeletal anomalies thought to result from impaired extracellular matrix remodeling during ossification, as yet unexplained muscular symptoms....