A5064820220- Hematopoietic Stem Cell Transplantation
- Complement system in diseases
- Lymphoma Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- CAR-T cell therapy research
- T-cell and B-cell Immunology
- Blood groups and transfusion
- Chronic Lymphocytic Leukemia Research
- Immune Cell Function and Interaction
- CNS Lymphoma Diagnosis and Treatment
- Neutropenia and Cancer Infections
- Hemoglobinopathies and Related Disorders
- Immunotherapy and Immune Responses
- Polyomavirus and related diseases
- Retinoids in leukemia and cellular processes
- Platelet Disorders and Treatments
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Acute Lymphoblastic Leukemia research
- Transplantation: Methods and Outcomes
- Renal Transplantation Outcomes and Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Adenosine and Purinergic Signaling
- Blood disorders and treatments
- Blood transfusion and management
Okayama University Hospital
2014-2024
Hiroshima City Asa Citizens Hospital
2024
Okayama University
2013-2022
Okayama Prefecture
2021
Taoka Hospital
2012
The Cancer Institute Hospital
2005-2010
Sapporo Medical University
1998-2005
Sapporo University
2005
Keiyukai Sapporo Hospital
2005
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, acquired disease characterized by chronic complement-mediated hemolysis. C5 inhibition controls intravascular hemolysis in untreated PNH but cannot address extravascular Pegcetacoplan, pegylated peptide targeting proximal complement protein C3, potentially inhibits both and
Abstract Background Pulmonary emphysema is characterized by alveolar destruction and persistent inflammation of the airways. Although IL-17A contributes to many chronic inflammatory diseases, it’s role in response elastase-induced remains unclear. Methods In a model pulmonary we examined IL-17A-deficient mice, monitoring airway inflammation, static compliance, lung histology levels neutrophil-related chemokine pro-inflammatory cytokines bronchoalveolar lavage (BAL) fluid. Results Wild-type...
Abstract Chronic graft-versus-host disease (GVHD) is a major cause of late death and morbidity after allogeneic hematopoietic cell transplantation, but its pathogenesis remains unclear. We investigated the role programmed death-1 (PD-1) pathway in chronic GVHD using well-defined mouse model B10.D2 (H-2d) donor to BALB/c recipients. PD-1 expression on T cells was upregulated continuously development, whereas PD-L1 host tissues transiently declined basal levels posttransplant period. Blockade...
Inflammatory process is involved in the pathogenesis of diabetic nephropathy. In this article, we show that cholecystokinin (CCK) expressed kidney and exerts renoprotective effects through its anti-inflammatory actions. DNA microarray showed CCK was upregulated wild-type (WT) mice but not intracellular adhesion molecule-1 knockout mice. We induced diabetes CCK-1 receptor (CCK-1R) CCK-2R double-knockout (CCK-1R(-/-),-2R(-/-)) mice, furthermore, performed a bone marrow transplantation study...
Mechanisms of prolonged cytopenia (PC) after chimeric antigen receptor (CAR) T-cell therapy, an emerging therapy for relapsed or refractory diffuse large B-cell lymphoma, remain elusive. Haematopoiesis is tightly regulated by the bone marrow (BM) microenvironment, called 'niche'. To investigate whether alterations in BM niche cells are associated with PC, we analysed CD271+ stromal biopsy specimens and cytokine profiles serum obtained before on day 28 CAR infusion. Imaging analyses revealed...
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, acquired hematologic disease characterized by complement-mediated hemolysis and thrombosis. Complement component 5 (C5) inhibitors have decreased PNH-related thrombosis rates reduced mortality compared with those of age-matched controls. A small but significantly increased risk life-threatening
Abstract Chronic graft-versus-host disease (GVHD) is a major cause of late death and morbidity after allogeneic hematopoietic cell transplantation. Recently, in addition to Th2 cells, Th1 Th17 cells have been shown contribute chronic GVHD progression. IL-12 induces IL-23 plays role stabilizing and/or amplifying as well inducing IFN-γ/IL-17 double-producing cells. Because mAb targeting the p40 subunit common both can inhibit IL-12R IL-23R-mediated signaling, we investigated effects anti-p40...
The standard CHOP therapy for peripheral T-cell lymphoma has resulted in unsatisfactory outcomes and it is still not clear what the optimal front-line therapy. We conducted a multicenter phase II study of dose-adjusted etoposide, doxorubicin, cyclophosphamide with vincristine prednisone (EPOCH) untreated patients. In this prospective study, 41 patients were treated dose-adjusted-EPOCH as initial therapy: lymphoma-not otherwise specified, n=21; angioimmunoblastic lymphoma, n=17; anaplastic...
Abstract The distribution and clinical impact of cell-of-origin (COO) subtypes diffuse large B-cell lymphoma (DLBCL) outside Western countries remain unknown. Recent literature also suggests that there is an additional COO subtype associated with the germinal center dark zone (DZ) warrants wider validation to generalize relevance. Here, we assembled a cohort Japanese patients untreated DLBCL determined refined subtypes, which include DZ signature (DZsig), using NanoString DLBCL90 assay. To...
BACKGROUND Transplant‐associated thrombotic microangiopathy (TA‐TMA) after hematopoietic stem cell transplantation (HSCT) remains a severe complication associated with underlying endothelial damage. TMA has high mortality rate no definite treatments and effective are needed. STUDY DESIGN AND METHODS The study objective was to retrospectively analyze the outcome of patients receiving recombinant human soluble thrombomodulin (rTM), which cytoprotective effects against calcineurin...
Recent preclinical and phase I studies have reported that rebamipide decreased the severity of chemoradiotherapy-induced oral mucositis in patients with cancer. This placebo-controlled randomized II study assessed clinical benefit reducing incidence severe head neck cancer (HNC). Patients aged 20–75 years HNC who were scheduled to receive chemoradiotherapy enrolled. 2% liquid, 4% or placebo. The primary endpoint was grade ≥ 3 determined by examination central review according Common...
Abstract Photodynamic therapy (PDT) is an emerging treatment for various solid cancers. We recently reported that tumor cell lines and patient specimens from adult T leukemia/lymphoma (ATL) are susceptible to specific death by visible light exposure after a short-term culture with 5-aminolevulinic acid, indicating extracorporeal photopheresis could eradicate hematological cells circulating in peripheral blood. As bridge basic research clinical trial of PDT malignancies, we here examined the...
Abstract Although chimeric antigen receptor T-cell (CAR-T) therapies have dramatically improved the outcomes of relapsed/refractory B-cell malignancies, recipients suffer from severe humoral immunodeficiencies. Furthermore, patients with coronavirus disease 2019 (COVID-19) a poor prognosis, as noted in several case reports who had COVID-19 before infusion. We report 70-year-old woman developed immediately CAR-T therapy for high-grade lymphoma. She received Tixagevimab−Cilgavimab chemotherapy...
Abstract This study investigated the efficacy of tisagenlecleucel (tisa-cel) and allogeneic hematopoietic stem cell transplantation (allo-SCT) for patients with relapsed and/or refractory (r/r) large B-cell lymphoma (LBCL) poor prognostic factors, defined as performance status (PS) ≥ 2, multiple extranodal lesions (EN), chemorefractory disease, or higher lactate dehydrogenase (LDH). Overall, allo-SCT group demonstrated worse progression-free survival (PFS), non-relapse mortality, a similar...
Chronic graft-versus-host disease (GVHD) remains a major late complication of allogeneic bone marrow transplantation (BMT). In previous study, impaired thymic negative selection the recipients permitted emergence pathogenic T cells that cause chronic GVHD using MHC class II-deficient (H2-Ab1 KO) B6 into C3H model and CD4(+) isolated from mice caused when administered secondary recipients. this we evaluated kinetics regulatory cell (Treg) reconstitution in wild type model. After myeloablative...