Oxidative stress is closely associated with the pathophysiology of diabetic cardiomyopathy (DCM). The mitochondrial flavoenzyme monoamine oxidase A (MAO-A) an important source oxidative in myocardium. We sought to determine whether MAO-A plays a major role modulating DCM. Diabetes was induced Wistar rats by single intraperitoneal injection streptozotocin (STZ). To investigate development pathophysiological features DCM, hyperglycemic and age-matched control were treated or without...

Tumor recurrence after radiotherapy due to the presence of breast cancer stem cells (BCSCs) is a clinical challenge, and mechanism remains unclear. Low levels ROS enhanced antioxidant defenses are shown contribute increasing radioresistance. However, role Nrf2-Keap1-Bach1 signaling in radioresistance BCSCs elusive. Fractionated radiation increased percentage ALDH-expressing subpopulation their sphere formation ability, promoted mesenchymal-to-epithelial transition BCSCs. Radiation activated...

Diabetic cardiomyopathy, a disorder of the heart muscle in diabetic patients, is one major causes failure. Since cardiomyopathy now known to have high prevalence asymptomatic patient, prevention at earliest stage development by existing molecules would be appropriate order prevent progression In this study, we investigated protective role multiple antioxidants (MA), on cardiac dysfunction and cell apoptosis streptozotocin (STZ)-induced rat. STZ-treated animals was characterized declined...

We evaluated the antihyperglycaemic effect of scoparic acid D (SAD), a diterpenoid isolated from ethanol extract Scoparia dulcis in streptozotocin (STZ)-induced diabetic male Wistar rats. SAD was administered orally at dose 10, 20 and 40 mg kg(-1) bodyweight for 15 days. At end experimental period, SAD-treated STZ rats showed decreased levels glucose as compared with control The improvement blood associated significant increase plasma insulin levels. exhibited when other doses. Further,...

Abstract Oxidative stress is implicated in the pathogenesis of diabetic complications. The experiments were performed on normal and experimental male Wistar rats treated with Scoparia dulcis plant extract (SPEt). effect SPEt was tested streptozotocin (STZ) Rat insulinoma cell lines (RINm5F cells) isolated islets vitro. Administration an aqueous by intragastric intubation (po) at a dose 200 mg/kg body weight significantly decreased blood glucose lipid peroxidative marker thiobarbituric acid...

Hypoxia and oxidative stress significantly contribute to breast cancer (BC) progression. Although hypoxia-inducible factor 1α (Hif-1α) is considered a key effector of the cellular response hypoxia, nuclear erythroid 2–related 2 (Nrf2), master antioxidant transcription factor, crucial essential for Hif-1α-mediated hypoxic responses. Hence, targeting Nrf2 could provide new treatment strategies therapy. miRNAs are potential regulators hypoxia-responsive genes. In quest identify novel...

<title>Abstract</title> Objective Diabetes is characterized by high blood glucose concentration which leads to oxidative stress auto-oxidation, resulting in pathological conditions like myocardial complications. This study focused on evaluation of the protective potential antioxidants against glucose/glucose oxidase (G/GO)-induced and cardiac cell damage. Methods H9c2 cells derived from muscles were exposed 33mM 1.6 milliunits for induction stress. Apoptosis was evaluated through markers...

We report here the isolation and characterization of a new compound Ailanthus excelsa chloroform extract-1 (AECHL-1) (C(29)H(36)O(10); molecular weight 543.8) from root bark Roxb. The possesses anti-cancer activity against variety cancer cell lines different origin.AECHL-1 treatment for 12 to 48 hr inhibited proliferation induced death in B16F10, MDA-MB-231, MCF-7, PC3 cells with minimum growth inhibition normal HEK 293. antitumor effect AECHL-1 was comparable that conventional drugs...

Abstract Background Numerous evidences suggest that diabetic heart is characterized by compromised ventricular contraction and prolonged relaxation attributable to multiple causative factors including calcium accumulation, oxidative stress apoptosis. Therapeutic interventions prevent accumulation could be therefore helpful in improving the cardiac function under condition. Methods This study was designed examine effect of long-acting channel blocker (CCB), Azelnidipine (AZL) on contractile...

Azelnidipine (AZL), a long-acting dihydropyridine-based calcium antagonist, has been recently approved and used for treating ischemic heart disease cardiac remodeling after myocardial infarction, however, its effect on hyperglycemia-induced damage not studied.This study examined the of AZL circulating markers damage, altered lipid cytokines profile oxidative stress including homocysteine in diabetic rats.STZ induced diabetes caused significant increase blood glucose levels. It also resulted...

Triple negative breast cancer (TNBC) features among the most aggressive manifestations of due to its enhanced metastatic potential and immunity therapeutics which target hormone receptors. Under such scenarios, anti-cancer compounds with an ability influence multiple targets, or entire process, will have advantage over specific signal transduction inhibitors. To counter threat it is essential cellular components central processes cell migration adaptation. Our previous work on a novel...

The modus operandi for an anti-cancer drug must allow efficient discrimination system between tumorigenic and non-tumorigenic cells. Targeting ER stress mitochondrial function in cancer cells appears to be a suitable option, as these processes are dysregulated tumor AECHL-1, novel triterpenoid, exhibits potent anticancer activity against array of cell lines however, its mechanism action remains elusive. Molecular targets AECHL-1 were investigated using breast adenocarcinoma MCF-7, MDA-MB-231...

Abstract Background Diabetic cardiomyopathy (DCM) is a leading cause of death in diabetic patients. Hyperglycemic myocardial microenvironment significantly alters chromatin architecture and the transcriptome, resulting aberrant activation signaling pathways heart. Epigenetic marks play vital roles transcriptional reprogramming during development DCM. The current study aimed to profile genome-wide DNA (hydroxy)methylation patterns hearts control streptozotocin (STZ)-induced rats decipher...