A5026069185- Wound Healing and Treatments
- Corneal Surgery and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Pluripotent Stem Cells Research
- Silk-based biomaterials and applications
- Dermatologic Treatments and Research
- 3D Printing in Biomedical Research
- Planarian Biology and Electrostimulation
- Burn Injury Management and Outcomes
- Pressure Ulcer Prevention and Management
- Nerve injury and regeneration
- Collagen: Extraction and Characterization
- Turtle Biology and Conservation
- Toxoplasma gondii Research Studies
- Cellular Mechanics and Interactions
- Herpesvirus Infections and Treatments
- Hair Growth and Disorders
- Reconstructive Facial Surgery Techniques
- Neonatal skin health care
- Biomedical Ethics and Regulation
University of Zurich
2012-2024
ETH Zurich
2019-2021
University Children's Hospital Zurich
2010-2019
Tissue engineering of clinically applicable dermo-epidermal skin substitutes is crucially dependent on the three-dimensional extracellular matrix, supporting biological function epidermal and dermal cells. This matrix essentially determines mechanical stability these to allow for safe convenient surgical handling. Collagen type I hydrogels yield excellent functionality, but their weakness tendency contract degrade does not producing transplants larger sizes. We show here that plastically...
Background: The management of deep partial-thickness and full-thickness skin defects remains a significant challenge. Particularly with massive defects, the current standard treatment, split-thickness grafting, is fraught donor-site limitations unsatisfactory long-term outcomes. A novel, autologous, bioengineered substitute was developed to address this problem. Methods: To determine whether could safely provide permanent defect coverage, phase I clinical trial performed at University...
The Chelonid fibropapilloma-associated herpesvirus (CFPHV; ChHV5) is believed to be the causative agent of fibropapillomatosis (FP), a neoplastic disease marine turtles. While clinical signs and pathology FP are well known, research on ChHV5 has been impeded because no cell culture system for its propagation exists. We have cloned BAC containing in pTARBAC2.1 determined nucleotide sequence. Accordingly, type D genome predominant gene order typical varicellovirus genus within...
Extensive full-thickness skin loss, associated with deep burns or other traumata, represents a major clinical problem that is far from being solved. A promising approach to treat large defects the use of tissue-engineered analogues nearly normal anatomy and function. In addition excellent biological properties, such substitutes should exhibit optimal structural mechanical features. This study aimed test novel dermo-epidermal based on collagen type I hydrogels, physically strengthened by two...
Abstract Limited donor sites and poor long-term outcomes with standard treatment for large skin defects remain a huge problem. An autologous, bilayered, laboratory-grown substitute (denovoSkin) was developed to overcome this problem has shown be safe in 10 pediatric patients Phase I clinical trial after transplantation. The goal of article report on 48-month results. participants the phase were followed up at yearly visits 5 years Safety parameters, including occurrence adverse events,...
Managing major pediatric burns remains a challenge for the entire multidisciplinary team. Limited donor sites make complete early wound closure impossible and need temporary cover options ideally autologous cultured skin increases. We report case of 5 year-old child with 95% total body surface area (TBSA) deep flame burn large scale application laboratory grown, dermo-epidermal analogue, termed Zurich Skin, justified permitted as compassionate use. In total, 1626 cm2 Skin were transplanted...
Autologous bio-engineered dermo-epidermal skin substitutes are a promising treatment for large defects such as burns. For their successful clinical application, the graft dressing must protect and support keratinocyte layer and, in many cases, possess antimicrobial properties. However, silver dressings may inhibit growth differentiation. The purpose of our study was to evaluate effect various wound on healing human hydrogel-based substitute preparation first-in-human trials. Human approved...
Life threatening burns of non-accidental origin in neonates are extremely rare. Their management represents a great challenge, particularly since necrosectomy deep and grafting at this young age technically very demanding. Thus, strategic surgical master plan is mandatory to achieve rapid definitive autologous coverage avoidance undue risks iatrogenic burden for the fragile neonatal patient. We present case four day-old neonate who sustained involving 40 % its total body surface area (TBSA)...