A5040435921- Climate Change and Health Impacts
- Autism Spectrum Disorder Research
- Risk Perception and Management
- Obsessive-Compulsive Spectrum Disorders
- Disaster Response and Management
- Psychosomatic Disorders and Their Treatments
- Health, psychology, and well-being
- Genetics and Neurodevelopmental Disorders
- Thermoregulation and physiological responses
- Mental Health and Psychiatry
- Health disparities and outcomes
- Risk and Safety Analysis
- Inflammatory Bowel Disease
- Posttraumatic Stress Disorder Research
- Air Quality and Health Impacts
- Radioactive contamination and transfer
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Congenital heart defects research
- Resilience and Mental Health
- Healthcare professionals’ stress and burnout
- Healthcare Policy and Management
- Psychological Well-being and Life Satisfaction
- Attention Deficit Hyperactivity Disorder
- Cytokine Signaling Pathways and Interactions
- Schizophrenia research and treatment
Sussex Partnership NHS Foundation Trust
2012-2024
Brighton and Sussex Medical School
2014-2024
National Health Service
2021
Committee on Climate Change
2019
Royal Sussex County Hospital
2012-2014
King's College Hospital
2014
King's College London
2006-2013
University of Edinburgh
2013
University of Bristol
2013
Brentwood Community Hospital
2013
<b>Objective</b> To assess whether perceptions of the swine flu outbreak predicted changes in behaviour among members public England, Scotland, and Wales. <b>Design</b> Cross sectional telephone survey using random digit dialling. <b>Setting</b> Interviews by between 8 12 May. <b>Participants</b> 997 adults aged 18 or more who had heard spoke English. <b>Main outcome measures</b> Recommended change (increases handwashing surface cleaning plans made with a "flu friend") avoidance behaviours...
Seasonal fluctuation in suicide has been observed many populations. High temperature may contribute to this, but the effect of short-term fluctuations on rates not studied.To assess relationship between daily and counts England Wales 1 January 1993 31 December 2003 establish whether heatwaves are associated with increased mortality from suicide.Time-series regression analysis was used explore quantify temperature. The impact two estimated.No spring or summer peak found. Above 18 degrees C,...
Background Climate change is expected to have significant effects on human health, partly through an increase in extreme events such as heatwaves. People with mental illness may be at particular risk. Aims To estimate risk conferred by high ambient temperature patients psychosis, dementia and substance misuse. Method We applied time-series regression analysis data from a nationally representative primary care cohort study. Relative of death per 1° was calculated above threshold. Results...
The summer of 2007 was the wettest in UK since records began 1914 and resulted severe flooding several regions. We carried out a health impact assessment using population-based surveys to assess prevalence risk factors for psychosocial consequences this United Kingdom.Surveys were conducted two regions postal, online, telephone questionnaires face-to-face interviews. Exposure variables included presence flood water home, evacuation disruption essential services (incident management...
Background Scales are widely used in psychiatric assessments following self-harm. Robust evidence for their diagnostic use is lacking. Aims To evaluate the performance of risk scales (Manchester Self-Harm Rule, ReACT SAD PERSONS scale, Modified Barratt Impulsiveness Scale); and patient clinician estimates identifying patients who repeat self-harm within 6 months. Method A multisite prospective cohort study was conducted adults aged 18 years over referred to liaison psychiatry services Scale...
<b>Objectives:</b> Aims were to investigate (a) whether neuroimaging in patients with chronic daily headache reassures or fails reassure them and/or worsens outcome, impacting on service use, costs, health anxieties, and symptoms, (b) this reassurance process occurs differentially different levels of psychological morbidity. <b>Methods:</b> Design: randomised controlled trial; setting: clinic secondary care, South London; participants: 150 fulfilling criteria for headache, stratified using...
Background Autistic spectrum disorder (ASD) is characterized by stereotyped/obsessional behaviours and social communicative deficits. However, there significant variability in the clinical phenotype; for example, people with autism exhibit language delay whereas those Asperger syndrome do not. It remains unclear whether localized differences brain anatomy are associated variation phenotype. Method We used voxel-based morphometry (VBM) to investigate adults ASD. included 65 diagnosed ASD (39...
Background: There is growing evidence suggesting an association between air pollution and suicide. However, previous findings varied depending on the type of pollutant study location. Objectives: We examined pollutants suicide in 10 large cities South Korea, Japan, Taiwan. Methods: used a two-stage meta-analysis. First, we conducted time-stratified case-crossover analysis to estimate short-term nitrogen dioxide (NO2), sulfur (SO2), particulate matter [aerodynamic diameter ≤10μm (PM10),...
Objective: The neural basis for autistic spectrum disorders is unclear, but abnormalities in the development of limbic areas and glutamate have been suggested. Proton magnetic resonance spectroscopy ( 1 H-MRS) can be used to measure concentration brain metabolites. However, glutamate/glutamine regions implicated has not yet examined vivo. Method: authors H-MRS investigate neuronal integrity amygdala-hippocampal complex a parietal control region adults with healthy subjects. Results: People...
Background Autism-spectrum disorder is increasingly recognised, with recent studies estimating that 1% of children in South London are affected. However, the biology comorbid mental health problems people autism-spectrum poorly understood. Aims To investigate brain anatomy and without psychosis. Method We used vivo magnetic resonance imaging compared 30 adults (14 a history psychosis) 16 healthy controls. Results Compared controls both groups had significantly less grey matter bilaterally...
It has been suggested that the restricted, stereotyped and repetitive behaviours typically found in autism are underpinned by deficits of inhibitory control. The biological basis this is unknown but may include differences modulatory role neurotransmitters, such as serotonin, which implicated condition. However, never tested directly. We therefore assessed modifying serotonin on brain function during a Go/No-Go task 14 adults with normal intelligence control subjects did not differ gender,...
Eleanor Balme and colleagues discuss the findings of a review that they have undertaken into need for, potential of, resilience training in doctors
2][3] Historically, withdrawal was thought to be mild and self-limiting, misnamed a 'discontinuation syndrome'; the 2022 National Institute for Health Care Excellence (NICE) depression guidance still states that symptoms 'usually go away within 1 2 weeks'. 4However, most patients will experience of longer than weeks. Additionally, contrary previous understanding, are often severe, can include increased suicidal ideation. 1,2naccurate on antidepressant has resulted in many experiencing...
People with autism spectrum disorders (ASDs) have lifelong deficits in social behavior and differences behavioral as well neural responses to facial expressions of emotion. The biological basis this is incompletely understood, but it may include the role neurotransmitters such serotonin, which modulate emotion processing health. While some individuals ASD significant serotonin system, our knowledge, no one has investigated its during adults control subjects using acute tryptophan depletion...
<b>Objectives</b> To identify public perceptions of the risk to health after poisoning Alexander Litvinenko with polonium-210 (<sup>210</sup>Po) in London and assess impact communications. <b>Design</b> Cross sectional telephone survey qualitative interviews. <b>Setting</b> London, United Kingdom. <b>Participants</b> 1000 people completed cross 86 potentially exposed <b>Main outcome measures</b> Perception personal <sup>210</sup>Po incident. Qualitative interviews were analysed an emphasis...
Almost all studies are prone to error—they use samples drawn from a population estimate what is occurring or might occur in the whole population. These errors can broadly be divided into two: random error and systematic error. Random play of chance results an effect (for example, relative risk) being equally likely above below true value. Its role assessed with statistical measures such as p values confidence intervals. Systematic called bias, also leads further information which relates...
Electronic patient records are increasingly used in primary care research, but rarely psychiatric research. Little is known about how people with pre-existing mental illness respond to public health threats.To outline the swine flu related concerns and behaviours of patients determine whether marked concern was associated any specific demographic or diagnostic groups.We searched a database containing electronic from large trust for references made between 15 April July 2009. Thematic...