A5039408378- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Crystallography and molecular interactions
- Advanced biosensing and bioanalysis techniques
- Circadian rhythm and melatonin
- Crystal structures of chemical compounds
- Biochemical and Molecular Research
- Mass Spectrometry Techniques and Applications
- Peptidase Inhibition and Analysis
- SARS-CoV-2 and COVID-19 Research
- Pharmacological Receptor Mechanisms and Effects
- Synthesis and biological activity
- Neuroendocrine regulation and behavior
- Natural Antidiabetic Agents Studies
- Boron Compounds in Chemistry
- Neuroscience and Neuropharmacology Research
- Molecular Sensors and Ion Detection
- Bioactive Compounds and Antitumor Agents
- Chemical Synthesis and Analysis
- Pineapple and bromelain studies
- Synthesis and Biological Evaluation
- Diverse Scientific Research Studies
- Cholinesterase and Neurodegenerative Diseases
- Receptor Mechanisms and Signaling
- Seed and Plant Biochemistry
Instituto Politécnico Nacional
2020-2025
Boron-containing compounds (BCC) have emerged as potential drugs. The effects of letting act drugs are mainly by means action on enzymes. Moreover, no crystal structure shows binding to G-Protein coupled receptors (GPCRs), albeit if those recognized targets in many diseases. However, some experimental data support the specific BCC GPCRs. Objective: Updating about reported that suggest or interactions GPCR. Methods: Data were collected and reviewed from National Center Biotechnology...
This research work involves the study of antioxidant activities methanolic extracts from three commonly consumed green leafy vegetables: Coriandrum sativum (coriander), Trigonella foenum-graecum (fenugreek), and Mentha arvensis (mint). The plant materials were extracted using methanol under reflux conditions, preliminary phytochemical screening revealed presence steroids, triterpenoids, saponins, alkaloids, carbohydrates, flavonoids, tannins, glycosides. potential was evaluated four...
A series of three 1,3-phenylene bis-oxamides 3a–c, structurally related to the GPR35 receptor-agonist drug lodoxamide, has been synthesized by reacting bis-oxalamates 2a and 2b with amines. The obtained compounds were characterized 1H 13C NMR, IR spectroscopy, they showed characteristic signals for aromatic, N―H, C=O groups. Molecular structure was determined using single-crystal X-ray diffraction. supramolecular architecture is driven N―H···O=C, N―H···N, C—H···π, O=C···O=C interactions...
Aims: This study investigates the therapeutic potential of bromelain extracted from pineapple fruit peel (Ananas comosus), focusing on its enzymatic activity, stability, and ability to enhance antibiotic efficacy. Study Design: was an experimental laboratory-based designed explore extraction, characterization, antimicrobial effects bromelain. Place Duration Study: The conducted at Enzymology unit laboratory FUTA over a period 4 months that allowed for purification, analysis bromelain's...
Background:: Treatment of the COVID19 pandemic requires drug development. Boron- containing compounds are attractive chemical agents, some them act as proteases inhibitors. Objective:: The present study explores role boronic moieties in molecules interacting on binding site SARS-CoV-2 main protease. Methods:: Conventional docking procedure was applied by assaying boron-free and boron-containing recently reported crystal structure protease (PDB code: 6LU7). set 150 ligands includes bortezomib...
Preclinical and clinical evidence supports melatonin its analogues as potential treatment for diseases involving cognitive deficit such Alzheimer's disease. In this work, we evaluated by in silico studies a set of boron-containing on MT1 MT2 receptors. Then, synthesized compound (borolatonin) identified potent agonist. After chemical characterization, evaluation rat model with showed that it induced ameliorative effects those equimolar administration behavioral tests neuronal...
Several arabinosyl-, xylosyl-, lyxosyl, 5'-deoxy-, acyclo-, 2,2'-anhydro-, 2,3'-anhydro-2'-deoxy-, 2,5'-anhydro-, 6,5'-cyclo-, and carbocyclic analogues of uridine with various 5-substitutions (fluoro, methyl, bromo, ethyl, benzyl, or benzyloxybenzyl) have been tested compared their corresponding ribo- 2'-deoxyribosides for potency to inhibit phosphorylase (UrdPase) from both mouse human livers. The effect the alpha- beta-configurations glycosidic bond was also tested. Xylo-, lyxo-, uridines...
Myeloperoxidase (MPO) is an enzyme present in human neutrophils, whose main role to provide defenses against invading pathogens. However, highly reactive oxygen species (ROS), such as HOCl, are generated from MPO activity, leading chronic diseases. Herein, we report the microwave-assisted synthesis of a new series stable (E)-(2-hydroxy)-α-aminocinnamic acids, good yields, which structurally analogous natural products (Z)-2-hydroxycinnamic acids. The radical scavenging activity (RSA),...
The aim of the present docking study was to explore putative role boronic moieties in molecules interacting on binding site SARS-CoV-2 main protease. methodology based conventional procedure by means AutoDock software assaying boron-free and boron-containing compounds recent reported crystal structure protease (PDB code: 6LU7). most tested share contact with key residues poses cleavage pocket. Those a boron atom its often were estimated higher affinity than analogues. Interactions...
Abstract Background Borolatonin is a potential therapeutic agent for some neuronal diseases such as Alzheimer's disease (AD). Its administration exerts ameliorative effects those induced by the equimolar of melatonin in behavioral tests on male rats and immunohistochemistry assays. Objective In this study, motivated sex differences neurobiology incidence AD, ability borolatonin to induce changes female was assessed. Methods Effects were measured evaluation both immunohistopathologic...
The use of tris(4-aminophenyl)amine (TAPA) as central to the synthesis both polyimines and polyimides covalent organic frameworks inorganic cages, among others, has grown in last few years. resulting materials exhibit high performance their area application. In this contribution, crystal structures two TAPA derivatives, triethyl (nitrilotris(benzene-4,1-diyl))tricarbamate (1) 2,2′,2″-((nitrilotris(benzene-4,1-diyl))tris(azanediyl))tris(2-oxoacetate) (2), are described. molecular...
Pyrimidine derivatives are fundamental heterocyclic compounds that serve as essential components of nucleic acids, including uracil, thymine, and cytosine. Modern synthetic approaches for functionalized pyrimidines encompass metal-catalyzed reactions, multicomponent coupling strategies, green chemistry protocols. The biological significance pyrimidine scaffolds has led to numerous therapeutic applications across multiple disease states. Pyrimidine-based drugs demonstrate potent antimicrobial...
The supramolecular structures of H 2 pOx·2S (S = DMSO, DMF, ⅓(MeOH·2W), W) solvates were stablished. energetics amide N–H⋯O and n/π → π* interactions maintain the crystal network reversibility between polymorphs.