A5051108674- 3D Printing in Biomedical Research
- Electrospun Nanofibers in Biomedical Applications
- Bone Tissue Engineering Materials
- Immune Cell Function and Interaction
- Dental Implant Techniques and Outcomes
- IL-33, ST2, and ILC Pathways
- Innovations in Concrete and Construction Materials
- Periodontal Regeneration and Treatments
- Microfluidic and Bio-sensing Technologies
- Wound Healing and Treatments
- Hydrogels: synthesis, properties, applications
University of Virginia
2024-2025
Duke University
2022
Microporous annealed particle (MAP) scaffolds are comprised of hydrogel microparticles with inter- and intra-particle cross-links that provide structure cell-scale porosity, making them an increasingly attractive option for injectable tissue augmentation. Many current biomaterials create a substantial foreign body response (FBR), while MAP mitigate this have the potential to facilitate formation new tissue, though de novo is poorly understood. Here, we leverage subcutaneous implant model...
The inflammatory foreign body response (FBR) is the main driver of biomaterial implant failure. Current strategies to mitigate onset a FBR include modification surface, release anti-inflammatory drugs, and cell-scale porosity. microporous annealed particle (MAP) scaffold platform an injectable, porous composed individual microgels, which are in situ provide structurally stable with microporosity. MAP does not induce discernible vivo and, therefore, can be used "blank canvas" for...
Microporous annealed particle (MAP) hydrogels are porous 3D scaffolds generated by interlinking randomly packed hydrogel microparticles (HMPs). Particle fraction, stiffness, microparticle shape, and crosslinking chemistry paramount to the microstructure that HMPs make within MAP scaffolds. Of these parameters, control over fraction in varies greatly user drying technique, leading inconsistent microarchitectures. These inconsistencies have biological ramifications, as of determines void space...