Can Lin

ORCID: 0000-0003-1690-3426
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About
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Research Areas
  • Immune Cell Function and Interaction
  • RNA modifications and cancer
  • Periodontal Regeneration and Treatments
  • Cancer-related gene regulation
  • Cytokine Signaling Pathways and Interactions
  • Macrophage Migration Inhibitory Factor
  • Aldose Reductase and Taurine
  • Extracellular vesicles in disease
  • Cancer-related molecular mechanisms research
  • Immunotherapy and Immune Responses
  • Oral microbiology and periodontitis research
  • interferon and immune responses

The First People's Hospital of Shunde
2023

Southern Medical University
2023

Wuhan University
2022-2023

Ki67 is a well-known proliferation marker with large size of around 350 kDa, but its biological function remains largely unknown. The roles in tumor prognosis are still controversial. has two isoforms generated by alternative splicing exon 7. and regulatory mechanisms progression not clear. In the present study, we surprisingly find that increased inclusion 7, total expression level, was significantly associated poor multiple cancer types, including head neck squamous cell carcinoma (HNSCC)....

10.3390/ijms24043872 article EN International Journal of Molecular Sciences 2023-02-15

Cryotherapy is a common non-pharmacological method to relieve pain and inflammation. Clinical studies have shown that cryotherapy can reduce postoperative after root canal therapy, but the mechanism remains unclear. In this study, we aimed investigate underlying molecular mechanisms by which reduces inflammation in lipopolysaccharide (LPS)-stimulated periodontal ligament cells through transcriptome sequencing analysis. We found significantly reduced expression of multiple proinflammatory...

10.3390/ijms241512097 article EN International Journal of Molecular Sciences 2023-07-28
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