A5072021941- Nicotinic Acetylcholine Receptors Study
- MicroRNA in disease regulation
- Biochemical Analysis and Sensing Techniques
- Neurogenesis and neuroplasticity mechanisms
- Circadian rhythm and melatonin
- Chemical Synthesis and Analysis
- RNA Research and Splicing
- Sleep and Wakefulness Research
- Dietary Effects on Health
- Smoking Behavior and Cessation
- RNA and protein synthesis mechanisms
University of Massachusetts Chan Medical School
2013-2020
Neuropsychiatric Research Institute
2013-2020
University of Zurich
2014
Abstract Tobacco use is the leading preventable cause of mortality in world. The limited number smoking cessation aids currently available are minimally effective, highlighting need for novel therapeutic interventions. We describe a genome-wide approach to identify potential candidates such Next-generation sequencing was performed using RNA isolated from habenulo-interpeduncular circuit male mice withdrawn chronic nicotine treatment. This plays central role withdrawal response....
Nicotine binds to and activates a family of ligand-gated ion channels, neuronal nicotinic acetylcholine receptors (nAChRs). Chronic nicotine exposure alters the expression various nAChR subtypes, which likely contributes dependence; however, underlying mechanisms regulating these changes remain unclear. A growing body evidence indicates that microRNAs (miRNAs) may be involved in regulation. Using bioinformatics, miRNA library screening, site-directed mutagenesis, gene analysis, we have...