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Contact & Profiles
A5016720386
Research Areas
- Chemical Synthesis and Analysis
- Mast cells and histamine
- Receptor Mechanisms and Signaling
Zhejiang University
2022
Abstract The histamine receptors belong to the G protein-coupled receptor (GPCR) superfamily, and play important roles in regulation of other neurotransmitters central nervous system, as potential targets for treatment neurologic psychiatric disorders. Here we report crystal structure human H 3 R bound an antagonist PF-03654746 at 2.6 Å resolution. Combined with computational functional assays, our reveals binding modes allosteric cholesterol. Molecular dynamic simulations molecular docking...
10.1038/s41467-022-33880-y
article
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cc-by
Nature Communications
2022-10-15
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