A5035873821- Complement system in diseases
- Liver Disease Diagnosis and Treatment
- Trypanosoma species research and implications
- Research on Leishmaniasis Studies
- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Drug-Induced Hepatotoxicity and Protection
- Bioactive Natural Diterpenoids Research
- Leptospirosis research and findings
- Alcohol Consumption and Health Effects
- Blood groups and transfusion
- Liver Disease and Transplantation
- Drug Transport and Resistance Mechanisms
- Endoplasmic Reticulum Stress and Disease
- Aquaculture disease management and microbiota
- Diet, Metabolism, and Disease
- Plant-derived Lignans Synthesis and Bioactivity
- Retinal Diseases and Treatments
- Pharmacogenetics and Drug Metabolism
- Clostridium difficile and Clostridium perfringens research
- Parasites and Host Interactions
- Malaria Research and Control
- Carbohydrate Chemistry and Synthesis
- Toxic Organic Pollutants Impact
- Air Quality and Health Impacts
Universidade Federal do Paraná
2017-2023
Fundação Carlos Chagas
2014-2023
Universidade de São Paulo
2010-2021
Hospital de Clínicas Universidade Federal do Paraná
2017-2021
Universidade Positivo
2018
Fundação Oswaldo Cruz
2015-2016
Social and epidemiological aspects of dengue were evaluated in an important metropolitan area southern Brazil, from August 2012 to September 2014. Demographic, clinical, serological data collected patients with acute symptoms treated at public health system units (HSUs). A systematic approach analyze the spatial temporal distribution cases was developed, considering cross-correlation between weather, correlation income over city's census tracts. From 878 suggestive symptoms, 249 diagnosed as...
Type 2 diabetes mellitus (T2DM) is associated with an increased risk of fractures. No study has evaluated the correlation bone histomorphometry (BH) parameters glycemic control and presence chronic complications (CCs) in premenopausal women T2DM.To evaluate BH correlate them degree CCs.This was a cross-sectional conducted at tertiary medical center. Twenty-six T2DM were divided into groups glycated hemoglobin HbA1c < 7% (good control, GC; n = 10) > (poor PC; 16), further subdivided (n 9)...
We report the isolation and characterization of dengue virus (DENV) serotype 4 from a resident Santa Fé, state Paraná, South Brazil, in March 2013. This patient presented with hemorrhagic manifestations, high viral load and, interestingly, mixed Th1/Th17 cytokine profile.The classical symptoms, such as fever, rash, myalgia, arthralgia, manifestations including petechiae, gum bleeding positive tourniquet test result. A serum sample obtained 1 day after initial appearance clinical symptoms was...
Alcoholic liver disease (ALD) is an important worldwide public health issue characterized by steatosis, inflammation, necrosis, and apoptosis of hepatocytes with eventual development fibrosis cirrhosis. Comparison murine models different inflammatory responses for ALD evaluation the importance genetic background in interpretation ethanol-induced phenotypes. Here, we investigated role inflammation establishment using two mouse strains: C57BL/6 (B6) A/J. B6 A/J mice were treated a high fat...
The pathogenesis of Dengue virus (DENV) infection is complex and involves viral replication that may trigger an inflammatory response leading to severe disease. Here, we investigated the correlation between viremia cytokine levels in serum DENV-infected patients. Between 2013 2014, 138 patients with a diagnosis acute-phase DENV 22 non-dengue acute febrile illness (AFI) were enrolled. Through focus-forming assay (FFU), determined observed peak first two days after onset symptoms. A higher...
The aim of this study was investigate the association between complement Factor H polymorphism (Y402H) and age-related macular degeneration (AMD) in Brazilian patients.Patients with AMD aged 50 or more age-matched healthy controls were enrolled study. Genomic DNA isolated from leucocytes patients controls; Y402H gene (CFH) determined by polymerase chain reaction directed sequencing.The frequency 1277C allele 56.30% compared 36.51% (p-value=0.001). genotypic distribution differed...
Leptospirosis is considered one of the most important zoonosis worldwide. The activation Complement System to control dissemination several pathogens in host. Only a few studies have employed murine models investigate leptospiral infection and our aim this work was role C5 during vivo infection, comparing wild type C57BL/6 (B6 C5+/+) congenic C5-/-, deficient) mice first days infection. All animals from both groups survived for at least 8 post-infection with pathogenic Leptospira interrogans...
Summary We aimed to investigate the association between plasma levels of complement Factor H ( FH ) with cardiac involvement, inflammatory and cardiometabolic parameters in patients chronic Chagas’ disease CD ). plasmatic were determined 80 patients. Glycaemic index, lipidogram (high‐density lipoprotein cholesterol HDL ‐C, low‐density LDL triglycerides total cholesterol) Ultrasensitive C‐Reactive Protein uCRP values obtained from medical records. Height, weight, body mass index BMI blood...
Leptospirosis is considered a neglected disease with an estimated more than one million cases every year. Since rodents are at the same time main reservoir and generally asymptomatic to Leptospira infection, understanding why some animal species resistant others susceptible this infection would shed light in how control important zoonosis. The innate immune response against mainly dependent on phagocytosis activation of Complement System. In context, cytokines may drive early adaptive...