A5054660624- Epilepsy research and treatment
- Metabolism and Genetic Disorders
- Pharmacological Effects and Toxicity Studies
- Infectious Encephalopathies and Encephalitis
- RNA regulation and disease
- Autoimmune Neurological Disorders and Treatments
- Genetics and Neurodevelopmental Disorders
- Birth, Development, and Health
- Neonatal and fetal brain pathology
- Amino Acid Enzymes and Metabolism
- Neurological disorders and treatments
- Folate and B Vitamins Research
- Fatty Acid Research and Health
- Genomics and Rare Diseases
- Neurological and metabolic disorders
- Cerebral Palsy and Movement Disorders
- Blood Coagulation and Thrombosis Mechanisms
- Cerebrospinal fluid and hydrocephalus
- Herpesvirus Infections and Treatments
- Glycogen Storage Diseases and Myoclonus
- Hereditary Neurological Disorders
- Magnesium in Health and Disease
- Lysosomal Storage Disorders Research
- Pharmaceutical studies and practices
- Congenital Anomalies and Fetal Surgery
Jawaharlal Nehru Medical College
2016-2025
Jawaharlal Nehru Medical College
2024
KLE University
2012-2022
Sarojini Naidu Medical College
2020-2022
KLE Society Hospital
2018
B. J. Medical College & Sassoon Hospital
2015
All India Institute of Medical Sciences
2006-2009
ABSTRACT Background SLC30A10 mutations cause an autosomal recessive disorder, characterized by hypermanganesaemia, polycythemia, early‐onset dystonia, paraparesis, or late‐onset parkinsonism, and chronic liver disease. This is the first identified inborn error of Mn metabolism in humans, reported 10 families thus far. Methods for this study consisted clinical examination, neuroimaging studies (MRI), serum dosages, genetic analysis. Results We describe early disease manifestations (including...
Abstract Objective KCTD7 ‐related progressive myoclonic epilepsy (PME) is a rare autosomal‐recessive disorder. This study aimed to describe the clinical details and genetic variants in large international cohort. Methods Families with molecularly confirmed diagnoses of PME were identified through collaboration. Furthermore, systematic review was done identify previously reported cases. Salient demographic, epilepsy, treatment, testing, electroencephalographic (EEG), imaging‐related variables...
A BSTRACT Postsurgical Guillain–Barré syndrome (GBS) is an unrecognized and uncommon complication seen in children. GBS complicated by severe acute hypertension secondary to dysautonomia can present as seizures because of underlying posterior reversible encephalopathy syndrome. The neuropathic symptoms following surgery are often missed attributed other postoperative problems like sedation pain. Here, we report a challenging case the period that was due autonomic dysfunction bowel surgery.
Paroxysmal sympathetic hyperactivity (PSH) is a less-known neurologic emergency that can be life-threatening. It form of extreme autonomic dysregulation leading to multiple episodes hyperactivity. The pathogenesis this interesting entity yet fully understood. presents as unexplained tachycardia, hypertension, and sometimes hyperthermia. Poor awareness fact leads unnecessary workup look for the cause fever interventions such change antibiotics. If it not treated adequately, even complications...
Department of Pediatric Neurology, Karnataka Lingayat Education Academy Higher and Research University's Jawaharlal Nehru Medical College, Belgaum, Karnataka, India Address for correspondence: Dr. Mahesh Kamate, Belgaum - 590 010, India. E-mail: [email protected]
Department of Pediatric Neurology, Karnataka Lingayat Education Society Academy Higher and Reaseach's Jawaharlal Nehru Medical College, Belgaum, Karnataka, India Address for correspondence: Dr. Mahesh Kamate, Belgaum - 590 010, India. E-mail: [email protected]
Intake of dietary docosahexaenoic acid (DHA 22:6n-3) is very low among Indian pregnant women. Maternal supplementation during pregnancy and lactation may benefit offspring neurodevelopment. We conducted a double-blind, randomized, placebo-controlled trial to test the effectiveness supplementing women (singleton gestation) from ≤20 weeks through 6 months postpartum with 400 mg/d algal DHA compared placebo on neurodevelopment their at 12 months. Of 3379 screened, 1131 were found eligible; 957...
Hypermanganesemia with dystonia 1 and 2 (HMNDYT1 2) are rare, inherited disorders of manganese transport.We aimed to describe clinical, laboratory features, outcomes among children HMNDYT.We conducted a retrospective multicenter study involving tertiary centers across India. We enrolled between month 18 years age genetically confirmed/clinically probable HMNDYT. Clinical, profile, genetic testing, treatment details, scored by treating physicians on Likert scale were recorded.We 27 (19...
Background: It is difficult to engage young children with cerebral palsy (CP) in repetitive, tedious therapy. As such, there a need for innovative approaches and tools motivate these children. We developed the low-cost, computer game-based rehabilitation platform CGR that combines fine manipulation gross movement exercises attention planning game activities appropriate CP. Objective: The objective of this study provide evidence therapeutic value improve upper extremity (UE) motor function...
We report the case of a 7-month-old child who presented with regression milestones, seizures, altered sensorium, and vomiting. An elder sibling had died similar complaints. Lead encephalopathy was considered because presence microcytic hypochromic anemia dense metaphyseal bands on wrist radiogram. Magnetic resonance imaging (MRI) brain revealed diffuse dysmyelination involving both periventricular subcortical white matter. Such changes have not been described previously. The child’s father...
Evidence suggests a strong association between nutrition during the first 1000 days (conception to 2 years of life) and cognitive development. Maternal docosahexaenoic acid (DHA) supplementation has been suggested be linked with development their offspring. DHA is structural component human brain retina, can derived from marine algae, fatty fish oils. Since Indian diets are largely devoid such products, plasma levels low. We testing effect pre- post-natal maternal in India on infant motor...
The study was carried out to investigate the safety of lacosamide on children with refractory partial epilepsy.The at a tertiary care hospital after obtaining approval from institutional ethics committee. Patients aged between 5 and 15 years taking oral (LCM) tablets that were given orally as an adjunctive anti-epileptic drug enrolled for assessing safety, tolerability its effect behavioural life every visit titration, during treatment period (3 months) 2 follow up visits done monthly...
Lacosamide is a newer antiepileptic drug with novel mode of action and being increasingly used in children as an add-on the treatment refractory epilepsy.Its safety, efficacy tolerance adults, favorable pharmacokinetic profiles are encouraging its use children.Because lack large studies full spectrum side effects this not clear.Though behavioral problems like agitation worsening behavior have been mentioned earlier case reports retrospective studies, there has no emphasis on inattention...