A5042883373- Advanced Drug Delivery Systems
- Advancements in Transdermal Drug Delivery
- Ocular Surface and Contact Lens
- Essential Oils and Antimicrobial Activity
- Collagen: Extraction and Characterization
- Periodontal Regeneration and Treatments
- Polysaccharides Composition and Applications
- Wound Healing and Treatments
- Advanced Cellulose Research Studies
- Bee Products Chemical Analysis
- Electrospun Nanofibers in Biomedical Applications
- Hydrogels: synthesis, properties, applications
- Nanoplatforms for cancer theranostics
- Osteoarthritis Treatment and Mechanisms
- Surgical Sutures and Adhesives
- Phytochemistry and biological activity of medicinal plants
- Skin Protection and Aging
- Surfactants and Colloidal Systems
- Proteoglycans and glycosaminoglycans research
- Analytical Chemistry and Chromatography
- Dyeing and Modifying Textile Fibers
- Phytochemistry and Biological Activities
- Acne and Rosacea Treatments and Effects
- Silk-based biomaterials and applications
- biodegradable polymer synthesis and properties
Carol Davila University of Medicine and Pharmacy
2016-2025
The goal of this paper was to design several sodium carboxymethylcellulose hydrogels containing a BCS class II model drug and evaluate their flow thixotropic properties. rheological measurements were performed at two temperatures (23 °C 37 °C), using rotational viscometer. stirred different time intervals (10 s, 2, 5, 10 20 min 23 °C, 2 5 with maximum speed 60 rpm, the corresponding forward backward rheograms recorded as shear stress vs. rate. For all hydrogels, data obtained both showed...
This research aimed to develop miconazole-based microemulsions using oleic acid as a natural lipophilic phase and stabilizer mixture comprising Tween 20 PEG 400 solubilize miconazole an antifungal agent known for its activity in oral candidiasis improve bioavailability. The formulation preparation process was combined with mathematical approach 23-full factorial plan. Fluid gel-like were obtained analyzed considering pH, conductivity, refractive index, followed by extensive analyses focused...
The aim of this study was the development and optimization some topical collagen-dextran sponges with flufenamic acid, designed to be potential dressings for burn wounds healing. were obtained by lyophilization hydrogels based on type I fibrillar collagen gel extracted from calf hide, dextran crosslinked un-crosslinked, according a 3-factor, 3-level Box-Behnken experimental design. showed good fluid uptake ability quantified high swelling ratio. acid release profiles presented two...
Buccal drug delivery systems often struggle with poor solubility, limited adhesion, and rapid clearance, leading to suboptimal therapeutic outcomes. To address these limitations, we developed a novel hybrid eutectogel composed of xanthan gum (XTG), hyaluronic acid (HA), Natural Deep Eutectic Solvent (NADES) system (choline chloride, sorbitol, glycerol in 2:1:1 mole ratio), incorporating 2.5% ibuprofen (IBU) as model drug. The formulation was optimized using face-centered central composite...
Objectives: The study explores the potential of various deep eutectic solvents (DESs) to serve as drug delivery systems and pharmaceutical excipients. research focuses on two primary objectives: evaluating ability selected DES enhance solubility poorly water-soluble model drugs (IBU MFA), their physicochemical properties, including density, viscosity, flow behavior, surface tension, thermal stability, water dilution effects, determine suitability for applications. Methods: A range containing...
Myrtus communis L. is one of the important aromatic and medicinal species from Mediterranean area. It used in various fields such as culinary, cosmetic, pharmaceutical, therapeutic, industrial applications. Thus, a Box–Wilson experimental plan was this study to select optimal operating conditions order obtain high volumes essential oils. The factorial design method applied evaluate at an scale effect major process variables on oil extraction herbs by steam distillation method. input...
The aim of this study was the development and optimization chitosan hydroxypropyl methylcellulose (HPMC) in situ gelling systems, loaded with bupivacaine hydrochloride for topical ocular administration. This is based on properties two polymers: chitosan, which has mucoadhesive action a pH-sensitive polymer, but also cellulose derivative methylcellulose, thermosensitive polymer increases viscosity systems. analysis systems were performed an experimental design response surface methodology....
This study focuses on the design, characterization, and optimization of nanostructured lipid carriers (NLCs) loaded with docetaxel for treatment skin cancer. Employing a systematic formulation development process guided by Design Experiments (DoE) principles, key parameters such as particle size, polydispersity index (PDI), zeta potential, entrapment efficiency were optimized to ensure stability drug-loading efficacy NLCs. Combined XRD cryo-TEM analysis employed NLC nanostructure evaluation,...
The present study brings to attention a method develop salicylic acid-based oil in water (O/W) microemulsions using tensioactive system based on Tween 80, lecithin, and propylene glycol (PG), enriched with vegetable oat phase hyaluronic acid. systems were physically characterized the Quality by design approach was applied optimize attributes of Box-Behnken modeling, combined response surface methodology. For this purpose, 3
We report in this paper the synthesis and characterization of a new collagen-based material. This material was obtained spongy form functionalized with an antibiotic, ciprofloxacin. The targeted applications these kind materials concern post-operative prophylaxis. vitro tests (antimicrobial, cytotoxic, drug release) showed that sponges concentration 0.75 g ciprofloxacin per gram collagen could be beneficial for desired applications.